Brahmajee K. Nallamothu

ORCID: 0000-0003-4331-6649
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About
Contact & Profiles
Research Areas
  • Acute Myocardial Infarction Research
  • Cardiac Arrest and Resuscitation
  • Cardiac Imaging and Diagnostics
  • Coronary Interventions and Diagnostics
  • Healthcare Policy and Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Health Systems, Economic Evaluations, Quality of Life
  • Trauma and Emergency Care Studies
  • Emergency and Acute Care Studies
  • Heart Failure Treatment and Management
  • Healthcare cost, quality, practices
  • Cardiac Health and Mental Health
  • Primary Care and Health Outcomes
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Disaster Response and Management
  • Venous Thromboembolism Diagnosis and Management
  • Mechanical Circulatory Support Devices
  • Atrial Fibrillation Management and Outcomes
  • Cardiovascular Health and Risk Factors
  • Cardiac Valve Diseases and Treatments
  • Blood Pressure and Hypertension Studies
  • Cardiac pacing and defibrillation studies
  • Cerebrovascular and Carotid Artery Diseases
  • Patient Satisfaction in Healthcare
  • Mobile Health and mHealth Applications

University of Michigan
2016-2025

VA Ann Arbor Healthcare System
2015-2025

Michigan Medicine
2016-2025

Ann Arbor VA Medical Center
2015-2024

VA Center for Clinical Management Research
2015-2024

Michigan United
2015-2024

Indiana University School of Medicine
2024

Indiana University – Purdue University Indianapolis
2024

Health Services Research & Development
2013-2023

Saint Luke's Hospital
2013-2023

<h3>Importance</h3> Despite increased focus on reducing opioid prescribing for long-term pain, little is known regarding the incidence and risk factors persistent use after surgery. <h3>Objective</h3> To determine of new minor major surgical procedures. <h3>Design, Setting, Participants</h3> Using a nationwide insurance claims data set from 2013 to 2014, we identified US adults aged 18 64 years without in year prior surgery (ie, no prescription fulfillments 12 months 1 month procedure). For...

10.1001/jamasurg.2017.0504 article EN JAMA Surgery 2017-04-12

The growing use of imaging procedures in the United States has raised concerns about exposure to low-dose ionizing radiation general population.We identified 952,420 nonelderly adults (between 18 and 64 years age) five health care markets across between January 1, 2005, December 31, 2007. Utilization data were used estimate cumulative effective doses from calculate population-based rates exposure, with annual defined as low (< or = 3 mSv), moderate (> 20 high 50 very mSv).During study...

10.1056/nejmoa0901249 article EN New England Journal of Medicine 2009-08-26

Prompt reperfusion treatment is essential for patients who have myocardial infarction with ST-segment elevation. Guidelines recommend that the interval between arrival at hospital and intracoronary balloon inflation (door-to-balloon time) during primary percutaneous coronary intervention should be 90 minutes or less. However, few hospitals meet this objective. We sought to identify strategies were significantly associated a faster door-to-balloon time.We surveyed 365 determine whether each...

10.1056/nejmsa063117 article EN New England Journal of Medicine 2006-11-13

<b>Objective</b>&nbsp;To determine the frequency of prescriptions for short term use oral corticosteroids, and adverse events (sepsis, venous thromboembolism, fractures) associated with their use. <b>Design</b>&nbsp;Retrospective cohort study self controlled case series. <b>Setting</b>&nbsp;Nationwide dataset private insurance claims. <b>Participants</b>&nbsp;Adults aged 18 to 64 years who were continuously enrolled from 2012 2014. <b>Main outcome measures</b>&nbsp;Rates corticosteroids...

10.1136/bmj.j1415 article EN cc-by-nc BMJ 2017-04-12

Expert guidelines advocate defibrillation within 2 minutes after an in-hospital cardiac arrest caused by ventricular arrhythmia. However, empirical data on the prevalence of delayed in United States and its effect survival are limited.

10.1056/nejmoa0706467 article EN New England Journal of Medicine 2008-01-03

Publicly available data sets hold much potential, but their unique design may require specific analytic approaches.To determine adherence to appropriate research practices for a frequently used large public database, the National Inpatient Sample (NIS) of Agency Healthcare Research and Quality (AHRQ).In this observational study 1082 studies published using NIS from January 2015 through December 2016, representative sample 120 was systematically evaluated required by AHRQ conduct NIS.None.All...

10.1001/jama.2017.17653 article EN JAMA 2017-11-28

It has been suggested that the survival benefit associated with primary percutaneous coronary intervention (PPCI) in ST-segment elevation myocardial infarction may be attenuated if door-to-balloon (DB) time is delayed by >1 hour beyond door-to-needle (DN) times for fibrinolytic therapy. Whereas DB are rapid randomized trials, they often prolonged routine practice. We hypothesized clinical practice, longer DB-DN would higher mortality rates and reduced PPCI advantage. also addition to delays,...

10.1161/circulationaha.106.638353 article EN Circulation 2006-10-31

Treatment delays in patients with ST-segment-elevation myocardial infarction (STEMI) transferred for primary percutaneous coronary intervention (PCI) may decrease the advantage of this strategy over on-site fibrinolytic therapy that has been demonstrated recent clinical trials. Accordingly, we sought to describe patterns times treatment undergoing interhospital transfer PCI United States.We analyzed STEMI between January 1999 and December 2002 National Registry Myocardial Infarction. The...

10.1161/01.cir.0000155258.44268.f8 article EN Circulation 2005-02-08

<b>Objective</b> To evaluate the association between door-to-balloon time and mortality in hospital patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction to assess incremental benefit of reductions times less than 90 minutes. <b>Design</b> Prospective cohort study enrolled American College Cardiology National Cardiovascular Data Registry, 2005-6. <b>Setting</b> Acute care hospitals. <b>Participants</b> 43 801 with intervention. <b>Main outcome...

10.1136/bmj.b1807 article EN cc-by-nc BMJ 2009-05-19

Although populations referred for coronary angiography are increasingly diverse, there is limited information on artery disease (CAD) prevalence and in-hospital mortality other than predominately white male patients.We examined gender ethnic differences in CAD a prospective cohort of patients angiographic evaluation stable angina (n=375,886) or acute syndromes (ACS; unstable myocardial infarction, n=450,329) at 388 US hospitals participating the American College Cardiology-National...

10.1161/circulationaha.107.726562 article EN Circulation 2008-04-01

Background: Patients with end-stage kidney disease (ESKD) on dialysis were excluded from clinical trials of direct oral anticoagulants for atrial fibrillation (AF). Recent data have raised concerns regarding the safety dabigatran and rivaroxaban, but apixaban has not been evaluated despite current labeling supporting its use in this population. The goal study was to determine patterns associated outcomes dialysis-dependent patients ESKD AF. Methods: We performed a retrospective cohort...

10.1161/circulationaha.118.035418 article EN Circulation 2018-06-28

ContextThe Centers for Medicare & Medicaid Services (CMS) and the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) measure report quality process measures acute myocardial infarction (AMI), but little is known about how these are correlated with each other degree to which inferences a hospital's outcomes can be made from its performance publicly reported processes.ObjectiveTo determine correlations among AMI core they explain variation in hospital-specific,...

10.1001/jama.296.1.72 article EN JAMA 2006-07-05

<h3>Context</h3>Despite the widespread use of percutaneous coronary intervention (PCI), appropriateness these procedures in contemporary practice is unknown.<h3>Objective</h3>To assess PCI United States.<h3>Design, Setting, and Patients</h3>Multicenter, prospective study patients within National Cardiovascular Data Registry undergoing between July 1, 2009, September 30, 2010, at 1091 US hospitals. The was adjudicated using appropriate criteria for revascularization. Results were stratified...

10.1001/jama.2011.916 article EN JAMA 2011-07-05

Background— Registry studies have suggested improvements in door-to-balloon times, but a national assessment of the trends times is lacking. Moreover, we do not know whether were shared equally among patient and hospital groups. Methods Results— This analysis includes all patients reported by hospitals to Centers for Medicare &amp; Medicaid Services inclusion time percutaneous coronary intervention (acute myocardial infarction-8) inpatient measure from January 1, 2005, through September 30,...

10.1161/circulationaha.111.044107 article EN Circulation 2011-08-23
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