A5081571599- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- Genetic Associations and Epidemiology
- Circular RNAs in diseases
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Folate and B Vitamins Research
- Extracellular vesicles in disease
- Phytochemicals and Antioxidant Activities
- Olfactory and Sensory Function Studies
- CRISPR and Genetic Engineering
- Biochemical Analysis and Sensing Techniques
- Antioxidant Activity and Oxidative Stress
- Inflammasome and immune disorders
- Coenzyme Q10 studies and effects
German Center for Neurodegenerative Diseases
2020-2025
University of North Carolina at Chapel Hill
2022
David H. Murdock Research Institute
2020
Carolinas Medical Center
2020
University of North Carolina at Charlotte
2019-2020
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
33 Introduction: Excess fructose intake has been linked to increased risk for dyslipidemia, insulin, 34 resistance, hyperuricemia, inflammation, and obesity. In this human study, we investigated if serum 35 CRP concentrations change after consumption, whether genetic variants 36 obesity status influences change. Methods: Blood was drawn before at four time points 37 administration of a load (n=57). Serum were measured, 38 11 single nucleotides polymorphisms (SNPs) (rs1205, rs1417938,...
ABSTRACT Retrotransposable elements (RTEs) have been implicated in the pathogenesis of several age‐associated diseases. Although model systems indicate that age‐ and sex‐dependent loss heterochromatin increases RTE expression, data from large human studies are lacking. Here we assessed expression levels 795 blood subfamilies 2467 participants population‐based Rhineland Study. We found more than 98% increased with both chronological biological age. Moreover, regulators involved silencing was...
MicroRNAs have been linked to brain disorders, but their relations with hippocampal structure and atrophy remain unexplored. As the hippocampus is pivotal for cognition dementia, understanding these specificity would elucidate microRNA involvement in health neurodegeneration. Here, using population-based data, we cross-sectionally longitudinally examined associations of blood-derived microRNAs left right volume, asymmetry, total volume. Expression putative target genes was measured at study...
Several dietary patterns are suggested to benefit health, potentially through DNA methylation changes. However, what extent adherence so-called healthy diets overlaps, whether these equally beneficial, and they affect health outcomes the same molecular mechanisms, remains unclear. Therefore, we investigated overlap in ten diet quality scores, examined associations of scores with both biological aging markers profiles. We used data from Rhineland Study, a large population-based cohort,...
SUMMARY The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in calls for better characterization understanding changes system. Here, we profiled whole blood transcriptomes 39 10 control donors enabling data-driven stratification based molecular phenotype....
Abstract INTRODUCTION Blood‐derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings identification novel miRNAs associated with domains, including their relation to brain structure the pathways they regulate, still lacking. METHODS We examined blood‐derived miRNA co‐expression clusters in structural magnetic resonance imaging measures, target gene expression, genetic variants 2869...
ABSTRACT INTRODUCTION Circulating microRNAs have been suggested as candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings identification novel associated with domains, including their relation to brain structure the pathways they regulate, are still lacking. METHODS We examined circulating microRNA co-expression clusters in structural MRI measures, target gene expression 2869 participants a population-based cohort. RESULTS Five...
Abstract Background As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several diseases. In this study, we aimed to investigate the relation whole blood quantitative measurements vascular function, explore their biological role through an integrative microRNA-gene expression analysis. Methods Peripheral microRNA was assessed RNA-Seq in 2606 participants (45.8% men, mean age: 53.93, age range: 30 95 years) from Rhineland Study,...
Watermelon, a rich source of lycopene, has garnered attention for cardioprotective effects including cholesterol reduction and promotion redox balance. It is unknown whether 100% watermelon juice may represent food-first approach to confer benefits lycopene. This study examined influences on serum lipids, antioxidant capacity. Secondly, the explored genetic lycopene metabolism bioavailability. A placebo-controlled, randomized, double-blind, crossover trial with postmenopausal women (n = 16,...
Abstract IMPORTANCE Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in older adults; however, its genetic basis remains largely unknown. OBJECTIVE To identify loci olfactory general population. DESIGN, SETTING AND PARTIICIPANTS This genome-wide association study meta-analysis (GWMA) included participants European ancestry (N = 22,730) enrolled four different large population-based studies,...
Abstract Metabolomic studies are increasingly used for both etiological and predictive research, but frequently report missing values. We hypothesized that interindividual genetic variation may account part of this missingness. Therefore, we performed a GWAS missingness in measured metabolite levels using an untargeted mass spectrometry-based platform the Netherlands Epidemiology Obesity Study (N=594) Rhineland (N=4,165). considered metabolites 10%-90% individuals cohorts (N=224)....
The human lipidome comprises numerous complex lipids, dysregulation of which can contribute to the pathogenesis a wide range diseases. Despite high heritability parts lipidome, genetic architecture many circulating lipid species and their structure remains mostly unknown. Thus, we performed genome-wide association studies on 970 267 fatty acid composite measures using samples from population-based Rhineland Study (n=6,096). We validated our findings corresponding data two other independent...
Abstract The hippocampus exhibits volumetric differences between the left and right hemispheres (LHCV RHCV) asymmetry, yet molecular mechanisms underlying these features remain unclear. In this study, we performed a meta-analysis of epigenome-wide association studies (EWAS) across six population-based cohorts (n=8,156; 53% women; mean age: 60.7 years) to identify blood-based methylation signatures associated with LHCV, RHCV, hippocampal asymmetry. Integrative cross-omics analyses using...
Abstract Retrotransposable elements (RTEs) have been implicated in the pathogenesis of several age-associated diseases. Although model systems indicate that age- and sex-dependent loss heterochromatin increases RTE expression, data from large human studies are lacking. Here we assessed expression levels 795 blood subfamilies 2467 participants population-based Rhineland Study. We found more than 98% increased with both chronological biological age. Moreover, regulators involved silencing were...
Abstract Background MicroRNAs have been linked to dementia. However, understanding their relation cognition in the general population is required determine potential use for detection and prevention of age‐associated cognitive decline preclinical Therefore, we examined association circulating microRNAs with performance a population‐based cohort possible underlying mechanisms. Method We used data from 2869 participants (55.6% women, mean age: 55.01 years, age range: 30 95 years) Rhineland...
INTRODUCTION:Periodontal disease (PD) is a common oral complication in head and cancer patients (HNC) who undergo radiation therapy (RT) [1,2,3].It has been previously shown that genetics play an important role PD development.OBJECTIVE: Our objective was to identify candidate single nucleotide polymorphisms (SNPs) associated with radiation-treated HNC patients.METHODS: Saliva DNA extracted from (n=65) at baseline prior RT. Clinical attachment loss (CAL) increment of >0.2 mm used as threshold...