Dennis O. Mook‐Kanamori
A5032537180- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Cardiomyopathy and Myosin Studies
- Lipoproteins and Cardiovascular Health
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Gestational Diabetes Research and Management
- Antioxidant Activity and Oxidative Stress
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Nutritional Studies and Diet
- Cholesterol and Lipid Metabolism
- Advanced Glycation End Products research
Leiden University
2014-2025
Leiden University Medical Center
2015-2024
Weatherford College
2024
The University of Tokyo
2023
Icahn School of Medicine at Mount Sinai
2023
The Lundquist Institute
2023
Harbor–UCLA Medical Center
2023
Loyola University Medical Center
2022
Huisarts en Wetenschap
2010-2021
GGD Haaglanden
2020
The susceptibility for various diseases as well the response to treatments differ considerably between men and women. As a basis gender-specific personalized healthcare, an extensive characterization of molecular differences two genders is required. In present study, we conducted large-scale metabolomics analysis 507 metabolic markers measured in serum 1756 participants from German KORA F4 study (903 females 853 males). One-third metabolites show significant males females. A pathway revealed...
Context Adverse environmental exposures lead to developmental adaptations in fetal life.The influences of maternal physical characteristics and lifestyle habits on firsttrimester the postnatal consequences are not known.Objective To determine risk factors outcomes associated with growth restriction.Design, Setting, Participants Prospective evaluation associations first-trimester crown rump length 1631 mothers a known reliable first day their last menstrual period regular cycle.Subsequently,...
An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations (rs9939609) samples, aged from early infancy to 13 years, 8 cohorts of European ancestry. found a positive additional minor (A) alleles 5.5 years onwards, but an inverse below age 2.5 years. Modelling median curves for each genotype using LMS method, we that carriers showed lower infancy, earlier adiposity rebound (AR), higher later childhood. Differences by...
Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of dysregulations across multiple biofluids over varying timescales glycaemic control is still lacking.Here we report broad metabolomics study clinical setting, covering 2,178 metabolite measures saliva, plasma from 188 individuals diabetes 181 controls Arab Asian descent. Using...
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing at an alarming rate. Elevated enzymes are a primary reason to refer patients for further testing. However, within the normal range do not exclude presence MASLD. We examined MASLD in middle-aged population with overweight and enzymes. In addition, we accuracy 4 sets noninvasive proxies included 1017 participants from Netherlands epidemiology obesity cohort study body mass index ≥25 kg/m 2...
In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for using saliva has been suggested as an effective approach identify affected individuals.The objective the study was noninvasive metabolic marker type 2 in saliva.In case-control diabetes, we used clinical metabolomics discovery screen diabetes-relevant readouts saliva, blood and urine reference. With combination three platforms based on nontargeted mass spectrometry, examined 2178...
DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 from 944 participants KORA population replication in a multi-ethnic cohort 344 individuals. We identify 98 CpG-protein associations (pQTMs) at stringent Bonferroni level significance. Overlapping transcriptomics, metabolomics, clinical endpoints suggest implication...
Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into function. However, the variants identified fall predominantly in non-coding regions their underlying mechanisms remain unclear. Here, we identify putative functional coding variation changes interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European...
Introduction It is crucial to understand the factors that introduce variability before applying metabolomics clinical and biomarker research. Objectives We quantified technical biological of both fasting postprandial metabolite concentrations measured using 1H NMR spectroscopy in plasma samples. Methods In Netherlands Epidemiology Obesity study (n = 6,671), 148 (101 metabolites belonging lipoprotein subclasses) were under states (150 minutes after a mixed liquid meal). Technical was...
Leptin influences food intake by informing the brain about status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated administering leptin. However, role genetic regulation in polygenic remains poorly understood. We performed an exome-based analysis up to 57,232 individuals diverse ancestries identify variants influence adiposity-adjusted concentrations. five novel variants, including four missense LEP,...
Early weight gain is associated with an increased risk of obesity. It not known whether rapid in foetal life and infancy also abdominal adiposity. We examined the associations postnatal growth characteristics fat mass at age 2 years.This study was performed 481 children participating a prospective cohort from early onward.Foetal second third trimester, birth years were related to (subcutaneous distance area, preperitoneal area) measured by ultrasound years.Foetal subcutaneous mass. Estimated...
Most studies investigating human metabolomics measurements are limited to a single biofluid, most often blood or urine. An organism's biochemical pool, however, comprises complex transboundary relationships, which can only be understood by metabolic interactions and physiological processes spanning multiple parts of the body. Therefore, we here propose data-driven network-based approach generate an integrated picture associations over fluids. We performed analysis 2251 metabolites measured...
Recently, five branched-chain and aromatic amino acids were shown to be associated with the risk of developing type 2 diabetes (T2D).We set out examine whether are also development hypertriglyceridemia.We determined serum concentrations 1,125 individuals KORA S4 baseline study, for which follow-up data available at F4 7 years later. After exclusion hypertriglyceridemia (defined as having a fasting triglyceride level above 1.70 mmol/L) baseline, 755 subjects remained analyses.Increased levels...
Abstract Background We characterised the phenotypic consequence of genetic variation at PCSK9 locus and compared findings with recent trials pharmacological inhibitors PCSK9. Methods Published individual participant level data (300,000+ participants) were combined to construct a weighted gene-centric score (GS). Seventeen randomized placebo controlled inhibitor included, providing on 79,578 participants. Results scaled one mmol/L lower LDL-C concentration. The GS (comprising 4 SNPs)...