Irene de Boer
A5054200425- Migraine and Headache Studies
- Cerebrovascular and genetic disorders
- Trigeminal Neuralgia and Treatments
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Olfactory and Sensory Function Studies
- Cardiovascular Syncope and Autonomic Disorders
- Retinal Diseases and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Genetic Associations and Epidemiology
- Suicide and Self-Harm Studies
- Nitric Oxide and Endothelin Effects
- Obesity, Physical Activity, Diet
- Retinal Imaging and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Metalloenzymes and iron-sulfur proteins
- Psychosomatic Disorders and Their Treatments
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Workplace Violence and Bullying
- Nicotinic Acetylcholine Receptors Study
- Medical Research and Practices
Leiden University Medical Center
2016-2025
Medical Research Council
2023
University of Bristol
2023
MRC Integrative Epidemiology Unit
2023
Leiden University
2019-2023
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Vrije Universiteit Amsterdam
2019
Amsterdam Neuroscience
2019
KU Leuven
2018
The causal association between the gut microbiome and development of migraine its subtypes remains unclear.The single nucleotide polymorphisms concerning were retrieved from gene-wide study (GWAS) MiBioGen consortium. summary statistics datasets migraine, with aura (MA), without (MO) obtained GWAS meta-analysis International Headache Genetics Consortium (IHGC) FinnGen Inverse variance weighting (IVW) was used as primary method, complemented by sensitivity analyses for pleiotropy increasing...
Cluster headache (CH) is a highly disabling primary disorder with complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims identify potential new targets for CH through proteome-wide mendelian randomization (PWMR). We used PWMR estimate the causal effects of plasma proteins on CH. analysis integrated...
Aim To determine whether our E-diary can be used to diagnose migraine and provide more reliable migraine-related frequency numbers compared patients’ self-reported estimates. Methods We introduced a self-developed including automated algorithms differentiating headache days, indicating patient has migraine. Reliability of the diagnosis in combination with two previously validated E-questionnaires was physician’s as gold standard patients referred Leiden Headache Clinic (n = 596). In subset...
Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested related migraine recent studies, but these evidence are observational essentially and cannot infer causal relationship. present study aims reveal relationship between WM using genetic data Mendelian randomization (MR).
Background In this study, we aimed to evaluate the differing global access acute and preventive medications for migraine tension-type headache. Methods A custom-built questionnaire created by members of International Headache Society Juniors Group was sent worldwide, including a list treatments This based on evidence-based medicine guidelines. For each treatment, participants were asked about availability, type reimbursement variability within their country. Results Eighty-four completed...
Objective Identifying common genetic variants that confer risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro‐Analysis program (LUCA) population (n = 840) and unselected controls from Netherlands Epidemiology of Obesity Study (NEO; n 1,457). Replication was performed Norwegian sample 144 cases Trondheim 1,800 Nord‐Trøndelag Health Survey (HUNT). Gene set tissue enrichment analyses, blood cell‐derived RNA‐sequencing genes...
Abstract Background and purpose The aim was to evaluate the effect of anti‐calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies on depressive symptoms in subjects with migraine determine whether predict treatment response. Methods Patients treated erenumab fremanezumab at Leiden Headache Centre completed daily E‐headache diaries. A control group included. Depressive were assessed using Hospital Anxiety Depression Scale (HADS) Center for Epidemiological Studies (CES‐D)...
<h3>Objective</h3> We aimed to evaluate the role of endothelial-dependent and endothelial-independent vascular reactivity in retinal vasculopathy with cerebral leukoencephalopathy systemic manifestations (RVCL-S) autosomal dominant arteriopathy subcortical infarcts (CADASIL), both small vessel diseases are considered models for stroke, dementia, migraine. <h3>Methods</h3> RVCL-S (n = 18) CADASIL 23) participants <i>TREX1</i> <i>NOTCH3</i> mutations, respectively, were compared controls...
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare, underrecognized, small vessel disease caused by heterozygous C-terminal truncating TREX1 mutations. The characterized vascular retinopathy, focal neurological complaints, cognitive decline wide range of manifestations, including Raynaud's phenomenon, anemia liver kidney disease. Eventually, RVCL-S leads to premature death. underlying pathological finding in nonatherosclerotic,...
Hemiplegic migraine (HM) is a rare subtype of with aura. Given that causal missense mutations in the voltage-gated calcium channel α1A subunit gene CACNA1A have been identified subset HM patients, we investigated whether patients without mutation an increased burden such variants "CACNA1x family". Whole exome sequencing data Australian cohort unrelated (n = 184), along public from gnomAD, as controls, was used to assess CACNA1x genes. We performed both variant and subject test. found...
Abstract Objective To evaluate self‐reported substance user profiles for individuals with migraine and compare these to the general population. Background There is increasing attention lifestyle influences such as use presumed triggers. Methods Data on were collected by survey in a large cohort from biannual Dutch population substances. A representative of patients ( n = 5176) 8370) was included. Patients subdivided into episodic (EM) chronic (CM). Substance consumption compared between...
Abstract Statins are thought to have positive effects on migraine but existing data inconclusive. We aimed evaluate the causal effect of such drugs migraines using Mendelian randomization. used four types genetic instruments as proxies for HMG-CoA reductase inhibition. included expression quantitative trait loci gene and variation within or near region. Variants were associated with low-density lipoprotein cholesterol, apolipoprotein B, total cholesterol. Genome-wide association study...