Iona Y. Millwood
A5057853321- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Alcohol Consumption and Health Effects
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Genetic and phenotypic traits in livestock
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Cardiovascular Health and Risk Factors
- Substance Abuse Treatment and Outcomes
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
- Cancer Risks and Factors
- Helicobacter pylori-related gastroenterology studies
- Hepatitis C virus research
- BRCA gene mutations in cancer
University of Oxford
2016-2025
Medical Research Council
2016-2025
Nuffield Health
2018-2025
MRC Population Health Research Unit
2019-2023
Lucerne University of Applied Sciences and Arts
2022
University of Wisconsin–Madison
2022
The Coordinating Center
2018
Qingdao Municipal Center for Disease Control and Prevention
2018
Eli Lilly (United Kingdom)
2016
Imperial College London
2000-2014
BackgroundModerate alcohol intake has been associated with reduced cardiovascular risk in many studies, comparison abstinence or heavier drinking. Studies east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect drinking patterns. We used to assess the relationships between and genotype-predicted mean men, contrasting findings men those women (few of whom drink).MethodsThe prospective China Kadoorie Biobank enrolled 512 715 adults...
Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites MI stroke subtypes. This study sought to investigate associations plasma metabolic markers with risks incident MI, ischemic (IS), intracerebral hemorrhage (ICH). In a nested case-control (912 1,146 IS, 1,138 ICH cases, 1,466 common control subjects) 30 79 years age in China Kadoorie Biobank, nuclear magnetic...
BackgroundStroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis treatment, little known about the short-term long-term prognosis after first stroke low-income middle-income countries, including China. We aimed to assess risk recurrent mortality for each major pathological types.MethodsThis population-based cohort study included adults aged 35–74 years without who were recruited China Kadoorie Biobank (CKB). A baseline survey was conducted...
Adherence to a combination of healthy lifestyle factors has been related considerable reduction cardiovascular risk in white populations; however, little is known whether such associations persist nonwhite populations like the Asian population.
BackgroundHelicobacter pylori infection is a major cause of non-cardia gastric cancer (NCGC), but its causal role in cardia (CGC) unclear. Moreover, the reported magnitude association with NCGC varies considerably, leading to uncertainty about population-based H screening and eradication strategies high-risk settings, particularly China, where approximately half all global cases occur. Our aim was assess associations infection, both overall for individual biomarkers, risks CGC Chinese...
Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues increase men. Large nationwide prospective studies linked different health records can help periodically assess disease burden attributed smoking. We aimed examine associations of with incidence mortality from an extensive range diseases China.We analysed data China Kadoorie Biobank, which recruited 512 726 adults aged 30-79 years, whom 210 201 were men 302 525 women....
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
The China Kadoorie Biobank (CKB) is a population-based prospective cohort of >512,000 adults recruited from 2004 to 2008 10 geographically diverse regions across China. Detailed data questionnaires and physical measurements were collected at baseline, with additional three resurveys involving ∼5% surviving participants. Analyses genome-wide genotyping, for >100,000 participants using custom-designed Axiom arrays, reveal extensive relatedness, recent consanguinity, signatures reflecting...
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies thoroughly investigated their best practices global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and PRS performance 9 biobanks for 14 disease endpoints. Specifically, we constructed PRSs using pruning thresholding (P + T) PRS-continuous shrinkage (CS). For both methods, a European-based...
Abstract Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples European ancestry. Here we report a multi-ancestry GWAS MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used range measures define included African (36% effective sample size), East Asian (26%) South (6%) ancestry Hispanic/Latin American participants (32%). The identified 53 significantly associated novel loci. For...
Circulating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity mortality. Here we developed a proteomic age clock the UK Biobank (n = 45,441) using platform comprising 2,897 explored its utility predict major disease morbidity mortality diverse populations. We identified 204 that accurately chronological (Pearson r 0.94) found aging was associated with incidence of 18 chronic...
Abstract Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels 2168 proteins in 3976 Chinese adults using both Olink Explore SomaScan The correlation protein between platforms was modest (median rho = 0.29), with abundance data quality parameters being key factors influencing correlation. For 1694 one-to-one matched reagents, 765 513 had cis -pQTLs, including...
Mean blood pressure varies moderately with outdoor air temperature in many western populations. Substantial uncertainty exists, however, about the strength of relationship other populations and its relevance to age, adiposity, medical treatment, climate housing conditions.To investigate season temperature, we analysed cross-sectional data from China Kadoorie Biobank study 506,673 adults aged 30-79 years recruited 10 diverse urban rural regions China. Analyses related mean - overall various...
An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations (rs9939609) samples, aged from early infancy to 13 years, 8 cohorts of European ancestry. found a positive additional minor (A) alleles 5.5 years onwards, but an inverse below age 2.5 years. Modelling median curves for each genotype using LMS method, we that carriers showed lower infancy, earlier adiposity rebound (AR), higher later childhood. Differences by...
Drinking alcohol has a long tradition in Chinese culture. However, data on the prevalence and patterns of consumption China, its main correlates, are limited.During 2004-08 China Kadoorie Biobank recruited 512,891 men women aged 30-79 years from 10 urban rural areas China. Detailed information was collected using standardized questionnaire, related to socio-demographic, physical behavioural characteristics separately.Overall, 76% 36% reported drinking some during past 12 months, with 33% 2%...
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these influence height growth during childhood. We derived peak velocity in infancy (PHV1) and puberty (PHV2) timing pubertal spurt from parametric curves fitted to longitudinal data test their known variants. The study consisted N = 3,538 singletons the prospective Northern Finland Birth Cohort 1966 genotype frequent measurements (on average 20 per...