Triin Laisk
A5042176597- Genetic Associations and Epidemiology
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Uterine Myomas and Treatments
- AI in cancer detection
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Gynecological conditions and treatments
- Gestational Diabetes Research and Management
- Dermatology and Skin Diseases
- SARS-CoV-2 and COVID-19 Research
- BRCA gene mutations in cancer
- Growth Hormone and Insulin-like Growth Factors
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Sleep and related disorders
- Renal Diseases and Glomerulopathies
University of Tartu
2015-2025
Estonian Biocentre
2021-2025
University of Southern California
2023
Massachusetts General Hospital
2022
Harvard University
2022
University of Helsinki
2022
Competence Centre on Health Technologies (Estonia)
2011-2019
Tartu University Hospital
2016
Université de Rouen Normandie
2011
Centre Hospitalier Universitaire de Rouen
2011
Abstract Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These survived the founding bottleneck rather than being distributed over large ultrarare variants. Although this effect is well established Mendelian genetics, its value common disease genetics less explored 1,2 . FinnGen aims to study genome and national health register data...
ABSTRACT Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles any gene is often concentrated on a small number low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survived founding bottleneck, opposed to being distributed over much larger ultra--rare variants. While this advantage well-- established Mendelian genetics, its value common disease genetics has been less explored. FinnGen aims study genome and...
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies thoroughly investigated their best practices global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and PRS performance 9 biobanks for 14 disease endpoints. Specifically, we constructed PRSs using pruning thresholding (P + T) PRS-continuous shrinkage (CS). For both methods, a European-based...
A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood.To disentangle the underlying architecture of and or other maternal hypertension during pregnancy with a genome-wide association study (GWAS) hypertensive disorders pregnancy.This GWAS included meta-analyses in combination phenotype encompassing disorders. Two overlapping groups were selected for examination, namely, pregnancy. Data from Finnish Genetics Pre-eclampsia Consortium...
Abstract We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals function tests validation cohort of 21,689 617,729 we identify validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism. One these, PNPLA3...
How can we study the full transcriptome of endometrial stromal and epithelial cells at single-cell level?By compiling developing novel analytical tools for biopsy, tissue cryopreservation disaggregation, sorting, library preparation, RNA sequencing (RNA-seq) statistical data analysis.Although analyses from various biopsied tissues have been published recently, corresponding protocols human endometrium not described.The frozen-thawed biopsies were fluorescence-activated cell sorted (FACS) to...
Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little known about its genetic architecture. We performed genome-wide association study ED in 6,175 case subjects among 223,805 European and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10-14), located between MCHR2 SIM1. In silico analysis suggests SIM1 to confer risk through hypothalamic dysregulation. Mendelian randomization provides evidence that...
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms interactions environmental triggers in multi-ethnic sample 6,073 cases 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 DPB1*04:02) discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant at TRA DQB1*06:02 loci...
Abstract Accurate placenta pathology assessment is essential for managing maternal and newborn health, but the placenta’s heterogeneity temporal variability pose challenges histology analysis. To address this issue, we developed ‘Histology Analysis Pipeline.PY’ (HAPPY), a deep learning hierarchical method quantifying of cells micro-anatomical tissue structures across whole slide images. HAPPY differs from patch-based features or segmentation approaches by following an interpretable...
Abstract Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls identify 25 genetic risk loci for male female We additionally 269 associated with follicle-stimulating hormone, luteinizing estradiol testosterone through sex-specific ( n = 6,095–246,862). Exome sequencing analyses reveal that women carrying testosterone-lowering rare variants some genes are at...
A prerequisite for successful embryo implantation is adequate preparation of receptive endometrium and the establishment maintenance a viable embryo. The success further relies upon two-way dialogue between uterus. However, molecular bases these preimplantation processes in humans are not well known. We performed genome expression analyses human embryos (n = 128) endometria 8). integrated data with protein-protein interactions order to identify networks within embryo, potential...