A5033015783- Sleep and Wakefulness Research
- Sleep and related disorders
- Restless Legs Syndrome Research
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Gastric Cancer Management and Outcomes
- Neuroscience of respiration and sleep
- Sphingolipid Metabolism and Signaling
- Genetics and Neurodevelopmental Disorders
- Migraine and Headache Studies
- Colorectal Cancer Surgical Treatments
- Infrared Thermography in Medicine
- Esophageal and GI Pathology
- Cardiovascular Issues in Pregnancy
- Eosinophilic Esophagitis
- Tracheal and airway disorders
- Gastrointestinal disorders and treatments
- Neuroscience and Neuropharmacology Research
- Esophageal Cancer Research and Treatment
- Photodynamic Therapy Research Studies
- Metastasis and carcinoma case studies
- Adenosine and Purinergic Signaling
- Obstructive Sleep Apnea Research
- Connective tissue disorders research
- Pancreatic and Hepatic Oncology Research
Oslo University Hospital
2016-2025
University of Oslo
2017-2025
Institutt for Eksperimentell Medisinsk Forskning
2025
Herlev Hospital
2024
Glostrup Hospital
2006-2019
Rigshospitalet
2015-2019
California Center for Sleep Disorders
2018
Norwegian University of Science and Technology
2017
Canadian Sleep & Circadian Network
2017
University of Copenhagen
2008-2016
Summary The aim of this study was to describe the clinical and PSG characteristics narcolepsy with cataplexy their genetic predisposition by using retrospective patient database European Narcolepsy Network ( EU ‐ NN ). We have analysed data 1099 patients diagnosed according International Classification Sleep Disorders‐2. Demographic characteristics, polysomnography multiple sleep latency test data, hypocretin‐1 levels, genome‐wide genotypes were available. found a significantly lower age at...
Abstract Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM) sleep behavior disorder (RBD). Although there are current American Academy of Sleep Medicine standards to diagnose RBD, several aspects need be addressed achieve harmonization across centers. Prodromal RBD a stage in which symptoms and signs evolving present, but do not yet meet established diagnostic criteria RBD. However, the boundary between prodromal definite still unclear. As common effort...
To compare clinical, electrophysiologic, and biologic data in narcolepsy without cataplexy with low (≤ 110 pg/ml), intermediate (110-200 normal (> 200 pg/ml) concentrations of cerebrospinal fluid (CSF) hypocretin-1.University-based sleep clinics laboratories.Narcolepsy (n = 171) control patients 170), all available CSF hypocretin-1.Retrospective comparison receiver operating characteristics curve analysis. Patients were also recontacted to evaluate if they developed by survival analysis.The...
To identify the factual morbidity and mortality of narcolepsy in a controlled design. National Patient Registry. All national diagnosed patients (757) with health information at least 3 years prior to after diagnose narcolepsy. Randomly selected four citizens (3,013) matched for age, sex, socioeconomic status from Danish Civil Registration System Statistics. Increased diagnosis included (odds ratio, 95% confidence interval):- diseases endocrine, nutritional, metabolic systems (2.10,...
Recent studies have found increased autoantibodies against Tribbles homolog 2 (anti-TRIB2) and anti-streptolysin O (ASO) in narcolepsy. In this study, we replicated finding with a primary focus on recent onset cases.Participants included (1) 90 cases cataplexy, (2) 57 without (3) 156 age-sex matched controls, including 73 human leukocyte antigen (HLA)-DQB1*0602 allele carriers. A radioligand binding assay was used to detect anti-TRIB2 antibodies.Anti-TRIB2 antibodies were prevalent...
Rapid eye movement sleep behaviour disorder is characterized by dream-enacting and impaired motor inhibition during rapid sleep. commonly associated with neurodegenerative disorders, but also reported in narcolepsy cataplexy. Most cataplexy patients lack the sleep–wake, sleep, motor-regulating hypocretin neurons lateral hypothalamus. In contrast, deficiency are rare without We hypothesized that coexists due to deficiency. our study, was diagnosed International Classification of Sleep...
Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in brain. Genetic, epidemiological and experimental data support hypothesis that NT1 T-cell-mediated autoimmune disease targeting hypocretin producing neurons. While autoreactive CD4+ T cells have been detected patients, CD8+ only examined to minor extent. Here we detect specific toward narcolepsy-relevant peptides presented primarily NT1-associated HLA types blood 20 patients...
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms interactions environmental triggers in multi-ethnic sample 6,073 cases 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 DPB1*04:02) discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant at TRA DQB1*06:02 loci...
To identify rare allelic variants and HLA alleles in narcolepsy patients with hypocretin (orexin, HCRT) deficiency but lacking DQB1*06:02.China (Peking University People's Hospital), Czech Republic (Charles University), Denmark (Golstrup Italy (University of Bologna), Korea (Catholic USA (Stanford University).CSF hypocretin-1, DQB1*06:02, clinical polysomnographic data were collected (552 144 without cataplexy) from 6 sites. Numbers cases DQB1*06:02 low CSF hypocretin-1 compiled. class I (A,...
The International Classification of Sleep Disorders (ICSD-2) criteria for low CSF hypocretin-1 levels (CSF hcrt-1) still need validation as a diagnostic tool narcolepsy in different populations because inter-assay variability and definitions hypocretin deficiency complicate direct comparisons study results. Interviews, polysomnography, multiple sleep latency test, HLA-typing, hcrt-1 measurements Danish patients with cataplexy (NC) without (NwC), other hypersomnias, neurological normal...
Narcolepsy is characterized by instability of sleep-wake, tonus, and rapid eye movement (REM) sleep regulation. It associated with severe hypothalamic hypocretin deficiency, especially in patients cataplexy (loss tonus). As the neurons coordinate stabilize brain's sleep-wake pattern, REM flip-flop neuronal centers animal models, we set out to determine whether deficiency and/or predicts unstable pattern human phenotype.We measured frequency transitions narcolepsy between states to/from NREM...
Several studies have suggested that hypocretin-1 may influence the cerebral control of cardiovascular system. We analyzed whether deficiency in narcolepsy patients result a reduced heart rate response. response during various sleep stages from 1-night polysomnography with and healthy controls. The group was subdivided by presence +/− cataplexy deficiency. Sleep laboratory conducted 2001-2011. In total 67 22 subjects were included study. Cataplexy present 46 38 patients. None. All had...
Cluster headache (CH) is a debilitating disorder characterized by unilateral, severe pain attacks with accompanying autonomic symptoms, often waking the patient from sleep. As it exhibits strong chronobiological traits and genetic studies have suggested link hypocretin (HCRT) system, objective of this study was to investigate HCRT-1 in CH patients.Cerebrospinal fluid concentration measured 12 chronic 14 episodic patients during an active bout, 27 healthy controls. The were well clinical...
We previously suggested clinical effects of early IV immunoglobulin (IVIg) treatment in sporadic narcolepsy with cataplexy (NC).[1][1] Below we present the first post-H1N1 vaccination NC case treated IVIg, 19 days after clear and abrupt onset disease. This is a single
Sleep is traditionally scored using 30-s epochs of polysomnographies. As sleep physiologically dynamic and may conceal important characteristics, we aim to challenge this standard by scoring in 5-s mini-epochs analyzing inter-rater variability between human automatic scorers. In 40 polysomnography recordings, 120 per were manually three experts (expert1_5s, expert2_5s expert3_5s) automatically a validated classifier (USleep_5s). Additionally, (clinical_5s) extracted from conventional...