A5063312041- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and Medication Impact
- Reproductive tract infections research
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- COVID-19 Impact on Reproduction
- Endometriosis Research and Treatment
- Grief, Bereavement, and Mental Health
- Ovarian function and disorders
- Reproductive Health and Technologies
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Maternal and fetal healthcare
- Reproductive Health and Contraception
- Maternal Mental Health During Pregnancy and Postpartum
- Preterm Birth and Chorioamnionitis
- Gynecological conditions and treatments
- Gut microbiota and health
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Gestational Diabetes Research and Management
- Global Maternal and Child Health
Rigshospitalet
2016-2025
Hvidovre Hospital
2020-2025
Copenhagen University Hospital
2016-2025
University of Copenhagen
2014-2025
Amager Hospital
2020-2025
Nielsen (United States)
2025
Zealand University Hospital Køge
2025
Poznan University of Medical Sciences
2024
Karolinska University Hospital
2023
Karolinska Institutet
2023
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid C-cell hyperplasia and tumors. Here, we report data supporting GLP-1 receptor-mediated mechanism these changes rodents. The receptor localized to rodent C-cells. agonists stimulated calcitonin release, up-regulation of gene expression, subsequently rats and, lesser extent, mice. In contrast, humans and/or cynomolgus monkeys had low...
Abstract STUDY QUESTION What are the updates for recommended management of women with recurrent pregnancy loss (RPL) based on best available evidence in literature from 2017 to 2022? SUMMARY ANSWER The guideline development group (GDG) updated 11 existing recommendations investigations and treatments RPL, how care should be organized, added one new recommendation adenomyosis investigation RPL. WHAT IS KNOWN ALREADY A previous ESHRE RPL was published needs updated. DESIGN, SIZE, DURATION...
Objectives To identify risk factors for and the consequences (several adverse perinatal outcomes) of physician-diagnosed major depression during pregnancy treated in specialised healthcare. Design A population-based cross-sectional study. Setting Data were gathered from Finnish health registers 1996–2010. Participants All singleton births (n=511 938) 2002–2010 Finland. Primary outcome measures Prevalence, pregnancy. Results Among 511 938 women, 0.8% experienced pregnancy, which 46.9% had a...
Abstract STUDY QUESTION How does hormonal contraceptive use and menstrual cycle phase affect the female microbiome across different body sites? SUMMARY ANSWER The phase, but not use, is associated with vaginal oral gut composition in healthy young women. WHAT IS KNOWN ALREADY Women low levels of Lactobacillus crispatus are at increased risk pre-term birth, fertility treatment failure, sexually transmitted infections gynaecological cancers. Little known about effect fluctuations on other...
Vaginal dysbiosis covers imbalances in the vaginal microbiota, defined by altered composition of bacteria, viruses, and fungi is associated with euploid pregnancy losses, premature birth, infertility, or bacterial vaginosis. A large proportion women who have do not experience any symptoms. Antibiotics are traditional treatment, recently combined local probiotics some cases. Microbiota Transplantation (VMT) eubiotic microbiota after antibiotic eradication pathogens has successfully been...
A live attenuated porcine reproductive and respiratory syndrome (PRRS) vaccine virus has been shown to revert virulence under field conditions. In order identify genetic determinants, ORF1 from the three Danish vaccine-derived isolates was sequenced compared with parental strain of (VR2332). This revealed five mutations that had occurred independently in all isolates, indicating strong parallel selective pressure on these positions when used swine herds. Two were direct reversions VR2332...
Is the prevalence of psychological stress and moderate/severe depression higher for women with recurrent pregnancy loss (RPL) than planners trying to conceive naturally? Both major are significantly more common among RPL in those naturally. has a significant emotional impact on couples, especially woman. Previous studies have shown inconclusive results. In this cross-sectional study, we compared 301 1813 attempting We defined as three or losses before 12 weeks' gestation. patients were...
This prospective study was carried out to develop a model for the prediction of cardiac risk in non-cardiac surgery. Detailed data were collected concerning preoperative status 2609 consecutive patients, who followed closely during postoperative course. Fatal or life-threatening complications occurred 68 patients (2.6%). By utilizing logistic regression, developed. The contained six significant predictor variables: Congestive heart failure (with 3 degrees severity); ischaemic disease 2...
To identify risk factors for fear of childbirth (FOC) according to parity and socioeconomic status, evaluate associations between FOC adverse perinatal outcomes.A cohort study.The Finnish Medical Birth Register.All 788 317 singleton births during 1997-2010 in Finland.Fear was defined the International Classification Diseases code O99.80, its with several outcomes were analysed by multivariable logistic regression.Prevalence of, FOC.Fear experienced 2.5% nulliparous women 4.5% multiparous...
To establish a method of estimating the proportion women with subsequent live birth after well-defined time period in an open cohort referred to tertiary recurrent miscarriage clinic.We performed descriptive study register-based follow-up at center for investigation and treatment Denmark. All primary or secondary clinic from 1986 2008 were included (n=987). Main outcome measures age-specific miscarriage-specific proportions first consultation similar hazard ratios compared prognosis aged...
To study how reproductive risks and perinatal outcomes are associated with postpartum depression treated in specialised healthcare defined according to the International Classification of Diseases (ICD)-10 codes, separately among women without a history depression.A retrospective population-based case-control study.Data gathered from three national health registers for years 2002-2010.All singleton births (n=511 422) Finland.Prevalence risk factors it.In total, 0.3% (1438 511 experienced...
To compare the ongoing pregnancy rate between a freeze-all strategy and fresh transfer in assisted reproductive technology treatment.Multicentre, randomised controlled superiority trial.Outpatient fertility clinics at eight public hospitals Denmark, Sweden, Spain.460 women aged 18-39 years with regular menstrual cycles starting their first, second, or third treatment cycle of vitro fertilisation intracytoplasmic sperm injection.Women were baseline on day 2 3 to one two groups: group...
Does maternal infection with severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in first trimester pregnancy have an impact on the fetal development as measured by nuchal translucency thickness and loss?Nuchal at scan was not significantly different pregnant women versus without SARS-CoV-2 early there no increased risk of loss trimester.Pregnant are more vulnerable to viral infections. Previous coronavirus epidemics been associated morbidity, mortality adverse obstetric outcomes....
Abstract A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy growth, we report genome-wide association analyses in the ( n = 65,405), 61,228) paternal 52,392) genomes, yielding 40 independent signals. Twenty-six signals are classified fetal, four three maternal. parent-of-origin effect seen near KCNQ1 . Genetic correlation colocalization reveal overlap with birth genetics, but 12 loci predominantly or only affecting...
The composition of the vaginal microbiota during menstrual cycle is dynamic, with some women remaining eu- or dysbiotic and others transitioning between these states. What defines dynamics, whether differences are microbiome-intrinsic mostly driven by host unknown. To address this, we characterized 49 healthy, young metagenomic sequencing daily swabs a cycle. We classified dynamics microbiome assessed impact behavior as well at species, strain, gene, phage levels.
Abstract Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between basic demographics lifestyle factors revealing expectable concentrations healthy individuals while considering general demographic differences. Methods A selection 47 biomarkers, including markers inflammation vascular stress, were measured plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined sex, age,...
Abstract Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls identify 25 genetic risk loci for male female We additionally 269 associated with follicle-stimulating hormone, luteinizing estradiol testosterone through sex-specific ( n = 6,095–246,862). Exome sequencing analyses reveal that women carrying testosterone-lowering rare variants some genes are at...