A5001931456- Reproductive System and Pregnancy
- Reproductive tract infections research
- Endometriosis Research and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Gynecological conditions and treatments
- Immune Cell Function and Interaction
- Pelvic floor disorders treatments
- Gut microbiota and health
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- COVID-19 Impact on Reproduction
- Urinary Tract Infections Management
- Preterm Birth and Chorioamnionitis
- Autism Spectrum Disorder Research
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Osteoarthritis Treatment and Mechanisms
- Sperm and Testicular Function
- Mesenchymal stem cell research
- Reproductive Health and Contraception
- Sexual function and dysfunction studies
- Genital Health and Disease
- Ovarian function and disorders
Hvidovre Hospital
2022-2025
Copenhagen University Hospital
2022-2025
University of Copenhagen
2025
Rigshospitalet
2023-2024
Innsbruck Medical University
2018-2023
Universität Innsbruck
2022-2023
University Hospital Innsbruck
2023
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2018
University Hospital Heidelberg
2015-2018
Heidelberg University
2011-2017
Vaginal dysbiosis covers imbalances in the vaginal microbiota, defined by altered composition of bacteria, viruses, and fungi is associated with euploid pregnancy losses, premature birth, infertility, or bacterial vaginosis. A large proportion women who have do not experience any symptoms. Antibiotics are traditional treatment, recently combined local probiotics some cases. Microbiota Transplantation (VMT) eubiotic microbiota after antibiotic eradication pathogens has successfully been...
Abstract STUDY QUESTION What is the global variability in recurrent implantation failure (RIF) definition, investigation and therapy, currently offered to patients undergoing IVF? SUMAMRY ANSWER Definitions, diagnostic investigations treatments RIF differ widely amongst assisted reproduction healthcare professionals clinical guidelines on are urgently needed. WHAT IS KNOWN ALREADY affects around 10% of IVF worldwide. There no consensus definition RIF, its or therapeutic options, which leads...
The composition of the vaginal microbiota during menstrual cycle is dynamic, with some women remaining eu- or dysbiotic and others transitioning between these states. What defines dynamics, whether differences are microbiome-intrinsic mostly driven by host unknown. To address this, we characterized 49 healthy, young metagenomic sequencing daily swabs a cycle. We classified dynamics microbiome assessed impact behavior as well at species, strain, gene, phage levels.
There is increasing evidence that many of the core behavioural impairments in autism spectrum disorders (ASD) emerge from disconnectivity networks are important for social communication. The present study aimed at investigating which specific fibre tracts impaired ASD and if possible alterations white matter associated with clinical symptomatology.Eighteen children 18 carefully matched typically developing controls aged 6-12 years were examined using diffusion tensor imaging (DTI)...
Problem Uterine natural killer (uNK) cells are major players during implantation and early pregnancy. The aim of our study was to analyze uNK cell concentration in the endometrium idiopathic recurrent miscarriage (iRM) patients fertile controls. Method Out n=130 couples with ≥3 consecutive, clinical RM screened according a standardized diagnostic protocol, n=58 iRM were identified. Endometrial biopsies investigated n=17 women (controls) via immunohistochemistry. Results Compared controls,...
In contrast to the former notion of a sterile womb, sequencing techniques have proven bacterial colonization uterus. However, timing microbiota analysis regarding possible intra-cycle variations as well specific alterations in patients with recurrent miscarriage (RM) or implantation failure (RIF) remain unknown. total, n = 20 RM-, RIF-patients and 10 healthy controls were included this prospective study. every subject, uterine flushing was performed during follicular, ovulatory luteal phase....
Background/Objectives: Treatment of knee osteoarthritis (OA) with autologous stem cells from microfragmented adipose tissue (MFAT) has shown promising but varying results. Multiple cell types, including CD34+, CD146+, and CD271+ cells, have been identified within MFAT. Patient-specific heterogeneity in populations the content highly potent may be determining factors for a successful treatment outcome. The current study aimed to identify most type MFAT treat OA, focusing on their chondrogenic...
Abstract Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic therapeutic challenge. The first German/Austrian/Swiss interdisciplinary S2k guideline on “Diagnosis Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. This developed the context of guidelines program German Society Gynecology Obstetrics (DGGG) cooperation Swiss (SGGG) Austrian (OEGGG). Aims One third causes involuntary...
Peripheral and uterine natural killer cells (pNK uNK cells) are key players in the establishment maintenance of pregnancy disturbed patients with recurrent miscarriage (RM). Different immunologic risk factors have been proposed between primary RM (pRM, no previous live birth) secondary (sRM, ≥ 1 birth). However, so far, study populations mainly consisted small subgroups. Therefore, we aimed to analyse pNK a large, well defined population within prospective study.In total, n = 575 (n 393 pRM,...
Abstract While roughly 30% of all women experience a spontaneous miscarriage in their lifetime, the incidence recurrent (habitual) is 1 – 3% depending on employed definition. The established risk factors include endocrine, anatomical, infection-related, genetic, haemostasis-related and immunological factors. Diagnosis made more difficult by sometimes diverging recommendations respective international specialist societies. present study therefore intended to provide comparison existing...
Endometriosis is often associated with severe dysmenorrhea, pelvic pain and dyspareunia has a high impact on daily life as well sexuality. Quality of partnership positively influences the course various diseases ability to cope emotional physical distress. However, studies focusing male partners endometriosis patients are rare, even less known about reciprocal relationship in these couples. Therefore, this study aims explore interrelations couples matters psychological distress, sexual...
Background: RPL and RIF are challenges in reproductive medicine. The immune system plays a pivotal role endometrial receptivity, successful implantation, pregnancy complications. Immunological changes have been associated with RIF. Understanding dysregulation especially NK T cell subtypes may lead to better diagnostic concepts treatments. From July 2019 August 2020 patients underwent standardized procedure including biopsies. Immune analysis was performed using flow cytometry. Patients were...
Abstract Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic therapeutic challenge. The first German-language interdisciplinary S2k guideline on “Diagnosis Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. developed the context of guidelines program German Society Gynecology Obstetrics (DGGG) cooperation Swiss (SGGG) Austrian (OEGGG). Aim In one third cases, cause involuntary...
(1) Background: Prior studies suggested a significant impact of previous live births on peripheral natural killer cells (pNK) in patients with recurrent pregnancy loss (RPL). Patients primary RPL (pRPL, no birth) showed higher numbers pNK than secondary (sRPL, ≥ 1 birth). (2) Methods: To further determine immunological differences between and controls, we analysed subpopulations activation markers pRPL (n = 47), sRPL 24) controls birth (sCtrl, n 25) nullipara (pCtrl, 60) within prospective...