A5036519887- Clostridium difficile and Clostridium perfringens research
- Inflammatory Bowel Disease
- Gut microbiota and health
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Escherichia coli research studies
- Gastrointestinal motility and disorders
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Immunodeficiency and Autoimmune Disorders
- Botany and Plant Ecology Studies
- Listeria monocytogenes in Food Safety
- Veterinary medicine and infectious diseases
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Parasitic Infections and Diagnostics
- Pharmacological Effects of Natural Compounds
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Exercise and Physiological Responses
- Amoebic Infections and Treatments
- Bariatric Surgery and Outcomes
Hvidovre Hospital
2016-2025
Copenhagen University Hospital
2016-2025
University of Copenhagen
2016-2025
Statens Serum Institut
2006-2024
Amager Hospital
2009-2024
Bristol-Myers Squibb (United States)
2022-2024
Aalborg University
2020
European Centre for Disease Prevention and Control
2019
Capital Region of Denmark
2009-2015
Universität Hamburg
2010
A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany May 2011. As July 22, a number cases E. have been reported--3167 without (16 deaths) 908 with (34 deaths)--indicating that this strain is notably more virulent than most strains. Preliminary genetic characterization suggested that, unlike these strains, it should be classified within enteroaggregative pathotype coli.We used...
Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. An increasing proportion DT104 isolates also reduced susceptibility fluoroquinolones.The Danish surveillance program determines the types all strains from food chain, case suspected outbreaks,...
Objective IBS is associated with an intestinal dysbiosis and faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients IBS. We performed randomised, double-blind placebo-controlled trial investigate if FMT resulted altered gut improvement clinical outcome Design this study 52 adult moderate-to-severe At the screening visit, history symptoms were assessed samples collected. Patients randomised or placebo capsules for 12 days followed 6 months. Study...
The degree to which molecular epidemiology reveals information about the sources and transmission patterns of an outbreak depends on resolution technology used samples studied. Isolates Escherichia coli O104:H4 from centered in Germany May-July 2011, much smaller southwest France June were indistinguishable by standard tests. We report a epidemiological analysis using multiplatform whole-genome sequencing multiple isolates German French outbreaks. showed remarkably little diversity, with...
Vaginal dysbiosis covers imbalances in the vaginal microbiota, defined by altered composition of bacteria, viruses, and fungi is associated with euploid pregnancy losses, premature birth, infertility, or bacterial vaginosis. A large proportion women who have do not experience any symptoms. Antibiotics are traditional treatment, recently combined local probiotics some cases. Microbiota Transplantation (VMT) eubiotic microbiota after antibiotic eradication pathogens has successfully been...
We present an analysis of strain and patient factors associated with the development bloody diarrhea hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark a 6-year period. Of 343 STEC patients, developed 36.4% HUS 6.1%. In multivariate logistic regression model, risk for were eae stx2 genes, O groups O157 O103, increasing age. Risk presence (odds ratio [OR] 18.9) (OR undefined) being child, having diarrhea. group O157, although...
Treatment with latency reversing agents (LRAs) enhances human immunodeficiency virus type 1 (HIV-1) transcription in vivo but leads to only modest reductions the size of reservoir, possibly due insufficient immune-mediated elimination infected cells. We hypothesized that a single drug molecule—a novel Toll-like receptor 9 (TLR9) agonist, MGN1703—could function as an enhancer innate immunity and LRA vivo. conducted single-arm, open-label study which 15 virologically suppressed HIV-1–infected...
Background and aim: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The probiotic bacterium Escherichia coli Nissle 1917 (EcN) has been used to maintain induce clinical remission in UC. Our aim was test the effect of Ciprofloxacin and/or orally administered EcN as add-on conventional therapies patients with active
Intestinal dysbiosis in inflammatory bowel disease (IBD) patients depend on activity. We aimed to characterize the microbiota after 7 years of follow-up an unselected cohort IBD according activity and severity. Fifty eight Crohn's (CD) 82 ulcerative colitis (UC) were included. Disease was assessed by Harvey-Bradshaw Index for CD Simple Clinical Colitis Activity UC. Microbiota diversity 16S rDNA MiSeq sequencing. In UC with active aggressive richness (number OTUs, p = 0.018 0.013,...
Abstract Inflammatory bowel disease (IBD) is a chronic intestinal disorder, with two main types: Crohn’s (CD) and ulcerative colitis (UC), whose molecular pathology not well understood. The majority of IBD-associated SNPs are located in non-coding regions hard to characterize since regulatory IBD known. Here we profile transcription start sites (TSSs) enhancers the descending colon 94 patients controls. IBD-upregulated promoters highly enriched for bound by same factors. IBD-specific TSSs...
Abstract Background Low-dose azathioprine in combination with allopurinol (LD-AZA/ALLO) is a widely used treatment option inflammatory bowel disease (IBD). Data on pregnancy and birth outcomes from exposure to therapy are sparse. The aim of this study was provide data safety risk for adverse women IBD treated LD-AZA/ALLO at the Gastrounit, Hvidovre Hospital, Copenhagen. Methods retrospective single center study. Inclusion criteria were established diagnosis (AZA 50-75 mg/ ALLO 100 mg) during...
Inflammatory bowel disease (IBD), Crohn's (CD), and ulcerative colitis (UC) are chronic diseases characterized by an inappropriate immune response, which may also increase the risk of infections. We investigated invasive pneumococcal (IPD) before after diagnosis IBD in a population-based cohort study.In 74,156 patients 1,482,363 non-IBD controls included followed during 1977-2013, hazard rate ratios (HRs) for IPD vs. were calculated Cox regression. Within group, we according to ever use...
There are challenges, when extracting bacterial DNA from specimens for molecular diagnostics, since fecal samples also contain human cells and many different substances derived food, cell residues medication that can inhibit downstream PCR. The purpose of the study was to evaluate two extraction methods in order choose most efficient method studying intestinal diversity using Denaturing Gradient Gel Electrophoresis (DGGE). In this study, a semi-automatic system (easyMag®, BioMérieux, Marcy...
To investigate the efficacy and safety of three different dosages embryonated, viable eggs Trichuris suis [TSO] versus placebo for induction remission in mildly-to-moderately active ileocolonic, uncomplicated Crohn's disease [CD]. Adults with CD [n = 252] randomly received six fortnightly doses 250, 2500, or 7500 TSO/15 ml suspension/day [TSO TSO 7500], 15 solution/day, a double-blind fashion, 4 weeks' follow-up. Primary endpoint was rate clinical [Crohn's Disease Activity Index [CDAI] <...
Aim: It was recently reported that serum retinol‐binding protein (RBP), also known as 4 (RBP4), positively associated with systemic insulin resistance. We hypothesized an imbalance between RBP and retinol might be the underlying cause for this association. Methods: studied ratio in 233 humans divided into groups depending on normal glucose tolerance (NGT), impaired (IGT), type 2 diabetes (T2DM) presence or absence of obesity. Results: Plasma levels were lower patients T2DM than individuals...