A5054417922- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle Physiology and Disorders
- Sports Performance and Training
- Vitamin C and Antioxidants Research
- Heat shock proteins research
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Sports injuries and prevention
- Epilepsy research and treatment
- Thermoregulation and physiological responses
- Immune Cell Function and Interaction
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circular RNAs in diseases
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Neurobiology and Insect Physiology Research
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Streptococcal Infections and Treatments
- MicroRNA in disease regulation
Copenhagen University Hospital
2005-2024
Amager Hospital
2024
University of Southern Denmark
2024
Odense University Hospital
2024
Hvidovre Hospital
2023
Charité - Universitätsmedizin Berlin
2016
Rigshospitalet
2005-2015
University of Copenhagen
2005-2014
University Hospital of Lausanne
2014
Hôpital Femme Mère Enfant
2014
The purpose of the present study was to test hypothesis that a transient increase in plasma IL-6 induces an anti-inflammatory environment humans. Therefore, young healthy volunteers received low dose recombinant human (rh)IL-6 or saline for 3 h. Plasma levels during rhIL-6 infusion were ∼140 pg/ml, corresponding obtained strenuous exercise. did not induce enhanced proinflammatory cytokine TNF-α but two cytokines IL-1 receptor agonist (IL-1ra) and IL-10 compared with infusion. In addition,...
Although IL-6 is a key modulator of immune function, it also plays role in regulating substrate metabolism. To determine whether affects lipid metabolism, 18 healthy men were infused for 3 h with saline (Con; n = 6) or high dose (High-rhIL6; low (Low-rhIL6; recombinant human (rhIL-6). The concentration during Con, Low-rhIL6, and High-rhIL6 was at steady state after 30 min infusion approximately 4, 140, 320 pg/ml, respectively. Either rhIL-6 associated similar increase fatty acid (FA)...
The mechanisms that mediate the tightly controlled production and clearance of glucose during muscular work are unclear, it has been suggested an unidentified “work factor” exists influences contraction-induced increase in endogenous (EGP). cytokine interleukin (IL)-6 is released from skeletal muscle contraction. Here we show IL-6 contributes to EGP. Six men performed 2 h bicycle exercise on three separate occasions, at a relatively high intensity (HI) or low with (LO + IL-6) without (LO)...
Skeletal muscle insulin resistance (IR) is considered a critical component of type II diabetes, yet to date IR has evaded characterization at the global gene expression level in humans. MicroRNAs (miRNAs) are fine-scale rheostats protein-coding product abundance. The relative importance and mode action miRNAs human complex diseases remains be fully elucidated. We produce map coding non-coding RNAs with aim identifying novel disease biomarkers. profiled >47,000 mRNA sequences >500 using...
Low muscle glycogen content has been demonstrated to enhance transcription of a number genes involved in training adaptation. These results made us speculate that at low would We therefore performed study which seven healthy untrained men knee extensor exercise with one leg trained low-glycogen (Low) protocol and the other high-glycogen (High) protocol. Both legs were equally regarding workload amount. On day 1, both (Low High) for 1 h followed by 2 rest fasting state, after was an...
Contracting human skeletal muscle is a major contributor to the exercise-induced increase of plasma interleukin-6 (IL-6). Although antioxidants have been shown attenuate IL-6, it unknown whether inhibit transcription, translation or translocation IL-6 within contracting muscle. Using single-blind placebo-controlled design with randomization, young healthy men received an oral supplementation either combination ascorbic acid (500 mg day(-1)) and RRR-alpha-tocopherol (400 i.u. (Treatment, n=...
It is recognized that the path from physical inactivity and obesity to lifestyle‐related diseases involves low‐grade inflammation, indicated by elevated plasma levels of inflammatory markers. Interestingly, contracting skeletal muscle a major source circulating interleukin‐6 (IL‐6) in response acute exercise, but with markedly lower trained subjects. As C‐reactive protein (CRP) induced IL‐6, we hypothesized basal IL‐6 CRP reflect degree regular activity when compared other markers...
IL-15 decreases lipid deposition in preadipocytes and the mass of white adipose tissue rats, indicating that may take part regulating this tissue. is expressed human skeletal muscle be a source plasma way regulate mass.The relation between mRNA expression, IL-15, was studied 199 humans divided into four groups on basis obesity type 2 diabetes. Furthermore, using DNA electrotransfer model, we assessed effect overexpression mice.In humans, multiple regression analysis showed negative...
Background: There is a considerable commercial market, especially within the sports community, claiming need for antioxidant supplementation. One argument supplementation in that physical exercise associated with increased reactive oxygen and nitrogen species (RONS) production, which may cause cell damage. However, RONS production also activate redox-sensitive signaling pathways transcription factors, subsequently, promote training adaptation. Purpose: Our aim was to investigate effects of...
FSP27 (fat-specific protein 27) is a member of the cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) family. Although Cidea and Cideb were initially characterized as activators apoptosis, recent studies have demonstrated important metabolic roles for these proteins. In this study, we investigated function another family, (Cidec), in apoptosis adipocyte metabolism. overexpression sufficient to increase 293T 3T3-L1 cells, more physiological levels expression stimulate...
The cytokine interleukin-6 (IL-6) exerts it actions via the IL-6 receptor (IL-6R) in conjunction with ubiquitously expressed gp130 receptor. is tightly regulated response to exercise, being affected by factors such as exercise intensity and duration, well energy availability. Although has been extensively studied, little known about regulation of IL-6R response. In present study, we aimed investigate effect training, glycogen availability, affect IL-6, on gene expression human skeletal...
Contracting skeletal muscle expresses large amounts of IL-6. Because 1) IL-6 mRNA expression in contracting is enhanced by low glycogen content, and 2) increases lipolysis oxidation fatty acids, we hypothesized that regular exercise training, associated with increased levels resting capacity to oxidize would lead a less-pronounced increase response acute exercise. Thus, before after 10 wk knee extensor endurance was determined young healthy men (n = 7) 3 h dynamic exercise, using the same...
Elevated plasma levels of the cytokines tumour necrosis factor-α and interleukin (IL)-6 have been consistently observed in patients with type 2 diabetes mellitus, as a consequence both related to insulin resistance and/or impaired glucose disposal (for review see Hotamisligil, 1999; Febbraio & Pedersen, 2002). Research from our laboratory has focussed on effect muscle contraction IL-6 response Pedersen et al. 2001). We demonstrated that contracting releases IL-6, this release can account for...
YKL-40 is produced by macrophages, and plasma elevated in patients with diseases characterized inflammation. In the present study, was examined relation to obesity, inflammation, type 2 diabetes.Plasma adipose tissue mRNA levels were investigated 199 subjects who divided into four groups depending on presence or absence of diabetes obesity. addition, healthy during a hyperglycemic clamp, which glucose level kept at 15 mmol/l for 3 h, hyperinsulinemic-euglycemic clamp.Patients had higher...