A5008574018- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Digestive system and related health
- Autoimmune and Inflammatory Disorders Research
- Pregnancy and Medication Impact
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Diverticular Disease and Complications
- Cytokine Signaling Pathways and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
Herlev Hospital
2016-2025
University of Copenhagen
2016-2025
Gentofte Hospital
1985-2024
Hospital South West Jutland
2024
University of Southern Denmark
2014-2024
Cornell University
1996-2023
Copenhagen University Hospital
1990-2022
Odense University Hospital
1986-2018
University of North Carolina Health Care
2015
Aarhus University Hospital
1986-2014
We assessed the familial occurrence of inflammatory bowel disease in Copenhagen County, where there has been a long-term interest epidemiology such disorders. In 1987 we interviewed 662 patients whom had diagnosed before 1979, asking whether their first- and second-degree relatives this disorder. Ninety-six percent (504 with ulcerative colitis 133 Crohn's disease) provided adequate information.As compared general population, first-degree 637 or 10-fold increase risk having same as patients,...
Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here, we show that human mouse fetal intestine contains proliferative, immature progenitors, which can be expanded vitro as Fetal Enterospheres (FEnS). A highly similar progenitor population established differentiation of induced pluripotent cells. Established cultures progenitors express lower levels...
Summary Background Dysbiosis is associated with many diseases, including irritable bowel syndrome ( IBS ), inflammatory diseases IBD obesity and diabetes. Potential clinical impact of imbalance in the intestinal microbiota suggests need for new standardised diagnostic methods to facilitate microbiome profiling. Aim To develop validate a novel test using faecal samples profile identify characterise dysbiosis. Methods Fifty‐four DNA probes targeting ≥300 bacteria on different taxonomic levels...
This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy subjects and patients with active or inactive ulcerative colitis (UC) Crohn's disease (CD) to substantiate the potential use spectroscopy as a non-invasive diagnostic tool characterize metabolome in inflammatory bowel (IBD). Stool samples 113 individuals (UC 48, CD 44, controls 21) were analyzed by 1H nuclear magnetic resonance (NMR) (Bruker 600 MHz, Bruker BioSpin, Rheinstetten, Germany). Data principal...
Purpose Chronic inflammatory diseases have been linked to increased risk of atherothrombotic events, but the associated with bowel disease (IBD) is unclear. We therefore examined myocardial infarction (MI), stroke, and cardiovascular death in patients IBD. Methods In a nationwide Danish population-based setting, cohort incident IBD between 1996 2009 were identified national registers. Hospitalizations as primary diagnosis, initiation biological treatment dispensed prescriptions...
The incidence of Crohn's disease increased sixfold from 1962 to 1987 in the county Copenhagen. mean annual for 1979-87 was 4.1 per 10(5) inhabitants. increase found equally both sexes, with an approximately 40% higher women. maximal 15- 24-year age group, being 12.8 year women and 6.0 men, as period 1979-87. prevalence at end study 54 inhabitants, 46 men 63 clinical appearance time diagnosis remarkably similar during regard localization symptoms signs. A slightly percentage patients,...
The course of pregnancy in 97 women with ulcerative colitis was studied over a 12-year period. During this period they had 173 pregnancies and delivered 136 children. There were two gemellary deliveries. Nine spontaneous 16 an induced abortion, which 4 performed on therapeutic indication. For woman the risk exacerbation bowel disease 32% per year her fertile years, whereas it 34% during pregnancy. This difference is not statistically significant. As compared inactive disease, whom active at...
The incidence of ulcerative colitis was estimated during the period 1962 to 1987 in county Copenhagen. Within this area approximately 550,000 inhabitants, 1161 patients were diagnosed. mean annual for 8.1 per 105 inhabitants. There significant increases early 1970s and 1980s, both which followed by decreases. A bimodal age distribution found men, with peaks young adult life late life. In women a peak group. interval from onset symptoms diagnosis terms years remained unchanged over period,...
Background: Cytokines are essential mediators of the intestinal inflammation during active episodes inflammatory bowel disease (IBD). Interleukin (IL)-12 and IL-17 potent immunoregulatory cytokines whose roles in pathogenesis IBD unknown. The aim this study was to evaluate colonic expression IL-12 genes IBD. Methods: Fifty-one patients (22 with ulcerative colitis (UC), 17 Crohn (CD), 12 controls) who underwent colonoscopy were included. activity determined using a clinical grading scale....
AbstractBackground: The prognosis of patients with ulcerative colitis (UC) has previously been described regard to mortality, cancer occurrence, and need for colectomy on the basis an annual follow-up a regional cohort UC in Copenhagen County diagnosed 1962–87. objective this study was examine spread disease evaluate possible prognostic factors by multivariate regression analysis. Methods: An inception 1161 examined actuarial analysis subgroup 467 1979–87. Results: probability further...
Assessment of disease activity in inflammatory bowel (IBD), i.e., ulcerative colitis (UC) and Crohn's (CD), is done using clinical parameters various biological markers. Ideally, a marker must: be able to identify individuals at risk given disorder, specific, mirror the and, finally, easily applicable for routine purposes. However, no such markers have yet been identified IBD. In this article, classical including erythrocyte sedimentation rate, acute phase proteins (especially orosomucoid...
Over a 13-year period, the course of 109 pregnancies in 68 women with Crohn's disease was studied. A total 76 children were delivered. There no gemellary deliveries, and none had congenital malformations. Pregnancy entailed increased risk an exacerbation bowel disease. As compared reference population ulcerative colitis, material showed premature delivery spontaneous abortion, but further analysis that this due only to active at time conception who undergone resection during pregnancy. Birth...
Nuclear magnetic resonance (NMR) spectroscopy and appropriate multivariate statistical analyses have been employed on mucosal colonic biopsies, colonocytes, lymphocytes, urine from patients with ulcerative colitis (UC) controls in order to explore the diagnostic possibilities, define new potential biomarkers, generate a better understanding of pathophysiology. Samples were collected active UC (n = 41), quiescent 33), 25) analyzed by NMR spectroscopy. Data analysis was carried out principal...