A5015310798- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Studies on Chitinases and Chitosanases
- Biliary and Gastrointestinal Fistulas
- Microscopic Colitis
- Bariatric Surgery and Outcomes
- Abdominal vascular conditions and treatments
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Intestinal Malrotation and Obstruction Disorders
- Protein Hydrolysis and Bioactive Peptides
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatological and COVID-19 studies
- Respiratory Support and Mechanisms
- Healthcare cost, quality, practices
- Hidradenitis Suppurativa and Treatments
- Psoriasis: Treatment and Pathogenesis
- Liver physiology and pathology
- Phytase and its Applications
- Inflammatory Bowel Disease
- Appendicitis Diagnosis and Management
Hvidovre Hospital
2011-2024
Copenhagen University Hospital
2014-2023
University of Copenhagen
2003-2019
Amager Hospital
2012
Rigshospitalet
2009
Glostrup Hospital
2009
Gentofte Hospital
2009
South Western Sydney Local Health District
2008
UNSW Sydney
2008
Knowledge of the natural course acute pancreatitis (AP) and risk progression to chronic (CP) is limited. The aims were describe: (1) incidence from AP CP, (2) prognostic factors for progression, (3) mortality progressive AP.During 1977 1982, patients admitted hospitals in Copenhagen with a diagnosis or CP included prospective cohort followed up by Danish registries 2008. subcohort analyses comprised 352 patients.Progressive was found 85 (24.1%) during follow-up; 48.2% developed alcoholic AP,...
Intestinal dysbiosis in inflammatory bowel disease (IBD) patients depend on activity. We aimed to characterize the microbiota after 7 years of follow-up an unselected cohort IBD according activity and severity. Fifty eight Crohn's (CD) 82 ulcerative colitis (UC) were included. Disease was assessed by Harvey-Bradshaw Index for CD Simple Clinical Colitis Activity UC. Microbiota diversity 16S rDNA MiSeq sequencing. In UC with active aggressive richness (number OTUs, p = 0.018 0.013,...
Objectives YKL-40 is secreted by macrophages, including those in atherosclerotic plaques, neutrophils, and vascular smooth muscle cells. Circulating elevated patients with inflammation increased tissue remodeling. The aim was to examine the sequential changes serum acute myocardial infarction (AMI), without thrombolytic therapy, as compared stable coronary artery disease (CAD). Methods measured radioimmunoassay from 63 patients. A total of 47 had their first AMI [30 ST segment elevation...
OBJECTIVES: Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between factors have mostly been limited to single or highly focused on etiologies. Using an objective data-driven approach (cluster analysis), we complication clusters their with in a large cohort patients CP. METHODS: This was multicenter, cross-sectional study including 1,071 CP from the Scandinavian Baltic countries....
Objectives: Chronic pancreatitis (CP) is a multifaceted disease associated with several risk factors and complex clinical presentation. We established the Scandinavian Baltic Pancreatic Club (SBPC) Database to characterise study natural history of CP in Northern European cohort. Here, we describe design database characteristics cohort.Methods: Nine centres from six different countries Scandinavian-Baltic region joined database. Patients definitive or probable (M-ANNHEIM diagnostic criteria)...
Abstract Background Updated population‐based estimates on incidence and prevalence of chronic pancreatitis are scarce. Methods We used nationwide healthcare registries to identify all Danish patients diagnosed with computed crude standardised rates in 1994–2018. Incidence were evaluated relation age gender, aetiology (alcoholic vs. non‐alcoholic) smoking alcohol consumption the general population. Results The mean rate during study period was 12.6 per 100,000 person years for total...
Summary Background Bile acid diarrhoea is often missed because gold standard nuclear medicine tauroselcholic [75‐Se] (SeHCAT) testing has limited availability. Empirical treatment effect unknown diagnostic performance, whereas plasma 7α‐hydroxy‐4‐cholesten‐3‐one (C4) inexpensive but lacks sensitivity. Aims To determine characteristics of empirical and explore improvements in diagnostics with potential better availability than SeHCAT. Methods This accuracy study was part a randomised,...
Diabetes mellitus is a common complication of chronic pancreatitis. It traditionally considered to develop as consequence beta cell loss, but there might be additional factors. Recent studies have highlighted the importance type 2 diabetes-related risk factors in this context and population-based show increased diabetes following acute The aim study was explore multiple for patients with pancreatitis.We conducted multicentre, cross-sectional definitive pancreatitis according M-ANNHEIM...
Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number patient disease characteristics. However, complex interrelations these parameters are incompletely understood, pain treatment remains unsatisfactory in large proportion patients. The aim this study to investigate multiple risk factors population CP patients, special emphasis on patients' patterns smoking alcohol use.This was multicenter, cross-sectional including 1384 patients CP. Patient demographics...
There is scarce information about risk factors for exocrine pancreas insufficiency (EPI) in chronic pancreatitis (CP), and how it associates with other complications. The aim of the present study was to examine EPI associations procedures CP related complications a large, Northern European cohort. We retrieved cross-sectional data on demographics, status EPI, aetiological CP, as well surgical endoscopic treatment from Scandinavian Baltic Pancreatic Club Database. Associations were assessed...
Chronic Pancreatitis (CP) causes morphological changes in the pancreatic tissue, leading to complications and pain, which may require endoscopic interventions.Our aim was determine frequency of procedures (EP) CP patients analyse pain quality life (QoL) these after their EP.This study included 1327 from Scandinavian Baltic Pancreatic Club (SBPC) database including four countries eight centres. We analysed undergoing EPs gathered information on EP, function, disease duration. The EORTC C-30...
Abstract Objectives Pancreatic exocrine insufficiency (PEI) is a common complication in patients with chronic pancreatitis (CP), leading to increased morbidity and mortality if not treated adequately. enzyme replacement therapy|pancreas therapy (PERT) the cornerstone treatment of PEI. In present study, we use data from Scandinavian Baltic Club database examine adherence PERT according United European Gastroenterology evidence‐based guidelines CP. Patients methods definitive or probable CP...
Abstract Aim The aim was to analyze the effects of drinking pattern and type alcohol on risk acute chronic pancreatitis. Methods Prospective cohort study based data from 316,751 men women participating in Danish National Health Surveys 2010 2013. Self-reported questionnaire-based parameters information pancreatitis obtained national health registers. Cox regression models were used adjusting for baseline year, gender, age, smoking, Body Mass Index, diet education. Results Development...
Background and aims. Knowledge of the long-term prognosis acute pancreatitis (AP) is limited. The aims were to investigate: (1) prognostic factors associated with mortality in patients AP; (2) whether or not level serum (S-)amylase at admission had an impact on prognosis; (3) causes death these patients. Methods. During 1977–1982, who admitted five main hospitals Copenhagen a diagnosis AP chronic (CP) included prospective cohort, Pancreatitis Study (CPS); 2008, they followed up by linkage...
INTRODUCTION: The diagnosis of bile acid diarrhea is often missed because the availability 75 seleno-taurohomocholic (SeHCAT) test limited. We aimed to compare biomarkers 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor 19 (FGF19) with SeHCAT test. METHODS: Patients chronic without intestinal resection referred for were prospectively recruited this diagnostic accuracy study. Blood was sampled at fasting after a stimulation meal chenodeoxycholic acid. retention ≤10% defined...
Chronic pancreatitis (CP) is thought to present the end stage of a continuous disease process evolving from acute (AP), over recurrent AP, early and end-stage CP. Due irreversible nature CP, detection prevention key. Prospective assessment based on advanced imaging modalities as well biochemical markers inflammation, fibrosis oxidative stress may provide better understanding underlying pathological processes help identify novel biomarkers with ultimate goal diagnosis, intervention...
Background and aims Several studies have shown improved short‐term outcome with endoscopic transmural drainage necrosectomy for the treatment of walled‐off pancreatic necrosis. However, knowledge on long‐term prognosis after such is limited. The aim present study was to evaluate outcomes in patients endoscopically treated necrosectomy. Methods We retrospectively follow up 125 necrosis 2010–2017. All received plastic pigtail stents nasocystic catheter. Additional external performed 41...