A5051050237- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Electrolyte and hormonal disorders
- Winter Sports Injuries and Performance
- Pneumonia and Respiratory Infections
- German Literature and Culture Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Surgery and Complications
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Nuclear Receptors and Signaling
- Gastrointestinal disorders and treatments
- Chronic Kidney Disease and Diabetes
- Potassium and Related Disorders
- Hops Chemistry and Applications
- Dermatological and COVID-19 studies
- IgG4-Related and Inflammatory Diseases
- Biliary and Gastrointestinal Fistulas
- Acute Kidney Injury Research
- Fungal Infections and Studies
- Ion Transport and Channel Regulation
Copenhagen University Hospital
1985-2023
Hvidovre Hospital
2001-2023
Amager Hospital
2022-2023
Pancreas Centre (Canada)
2022
University of California, San Francisco
2018-2019
University of Copenhagen
1985-2016
Slagelse Hospital
1996
University of Michigan
1994
Sjællands Universitetshospital, Nykøbing F.
1993
Objective In treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, increased drainage capacity a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted study comparing DPT in WON. Design A single-centre, open-label, randomised, controlled superiority trial using an...
Cirrhotic patients exhibit a hyperdynamic and hyporeactive circulation with central hypovolaemia which may influence the course of disease. As terlipressin, vasopressin analogue, modify systemic haemodynamics in these patients, aim present study was to assess acute effects terlipressin on haemodynamics.Sixteen alcoholic cirrhosis portal hypertension had their systemic, central, splanchnic determined at baseline after blind randomised bolus infusion (2 mg) terlipressin/placebo.After arterial...
Objectives. Carvedilol is a non-selective β-blocker with intrinsic anti-α1-adrenergic activity, potentially more effective than propranolol in reducing hepatic venous pressure gradient (HVPG). We compared the long-term effect of carvedilol and on HVPG assessed whether acute response to oral predicted either drug. Material methods. was measured 38 patients cirrhosis ≥ 12 mm Hg at baseline then again 90 min after an dose 80 mg propranolol. Patients were double-blinded randomized (21 patients)...
Significance How arthritis-causing T cells trigger rheumatoid arthritis (RA) is not understood since it difficult to differentiate activated by inflammation in arthritic joints from those through their cell antigen receptor (TCR) self-antigens. We developed a model identify and study antigen-specific responses arthritis. Nur77—a specific marker of TCR signaling—was used antigen-activated the SKG patients with RA. Nur77 could distinguish highly arthritogenic autoreactive mice. The enhanced...
Patients with cirrhosis and portal hypertension have an altered blood volume distribution a hyperdynamic systemic circulation. Terlipressin is known to reduce pressure by decreasing splanchnic inflow, but its effect on the unknown. The aim of study was investigate changes in regional haemodynamics after administration terlipressin patients cirrhosis.Blood determined 13 dual-head gamma-camera technique measured before intravenous (2 mg).Terlipressin increased thorax region (+6.0%, P < 0.002)...
Cystatin C is a low molecular weight protein and the plasma level of cystatin mainly determined by glomerular filtration, making an endogenous marker filtration rate. The aim study was to elucidate applicability as renal function in patients with liver cirrhosis. Serum creatinine concentrations were compared clearance. Thirty-six (14 females 22 males aged between 33 81 years) cirrhosis normal severely impaired kidney included. Plasma measured automated particle-enhanced nephelometric...
Seventeen patients with chronic pancreatitis and dilated pancreatic ducts were randomly allocated to coeliac plexus block or pancreaticogastrostomy. The number of pain relief after pancreaticogastrostomy did not differ at discharge. Pain score use analgesics before 6 months later unaffected but significantly less Operation decreased tissue pressure significantly. This decrease is believed explain relief.
Acute pancreatitis with walled-off necrosis (WON) is associated considerable morbidity and mortality. Previous studies have evaluated outcomes in WON collections of limited size, while data about large long-term follow-up are lacking. We aimed to report our experience managing WON.Between 2010 2020, consecutive patients (>15 cm) were identified from a prospectively maintained database. Patients chronic or an index intervention 90 days more the debut symptoms excluded. registered clinical...
This study aimed to evaluate the influence of fungal infection and antifungal treatment on outcome in patients with walled-off pancreatic necrosis (WON).A retrospective description infections a cohort consecutive undergoing endoscopic, transmural drainage necrosectomy for WON, treated tertiary referral center was reviewed.Between 2005 2013, WON documented 57 (46%) 123 patients. The most common isolates at first positive culture were Candida albicans (55%) glabrata (20%). Thirty-nine (70%)...
Chronic pancreatitis (CP) is thought to present the end stage of a continuous disease process evolving from acute (AP), over recurrent AP, early and end-stage CP. Due irreversible nature CP, detection prevention key. Prospective assessment based on advanced imaging modalities as well biochemical markers inflammation, fibrosis oxidative stress may provide better understanding underlying pathological processes help identify novel biomarkers with ultimate goal diagnosis, intervention...
Background and AimsEUS-guided drainage and, if required, endoscopic necrosectomy (EN) has become the criterion standard for treatment of pancreatic walled-off necrosis (WON). A dedicated powered debridement system, EndoRotor (Interscope Inc, Northbridge, Mass, USA), been introduced as an alternative to snare necrosectomy. This study evaluates novel catheter, NecroMax 6.0 Whitinsville, EN in patients with WON.MethodsThis single-center retrospective case series included consecutive WON treated...
Autoimmune pancreatitis (AIP) is a rare inflammatory disease. AIP has characteristic histology, serology and imaging findings. Two types of exist, type 1, which part the systemic immunoglobulin G4-related disease, 2, only localized to pancreas. Patients with 1 are predominantly older men, have involvement other organs more often experience relapse than patients 2. Both respond well steroid treatment. The most important differential diagnose pancreatic cancer.
Infected walled-off necrosis is a potentially life-threatening complication of necrotizing pancreatitis. While some patients can be treated by drainage alone, many also need evacuation the infected debris. Central necroses in relation to pancreatic bed are easily reached via an endoscopic transluminal approach, whereas that involve paracolic gutters and pelvis most efficiently percutaneous approach. Large complex may combination two methods.Transluminal followed simultaneous modified...
Endoscopic ultrasound (EUS) is a new modality allowing real-time flow measurements by means of the Doppler technique. The aim study was to evaluate azygos blood endoscopic ultrasound.Measurements EUS and thermodilution technique were compared in 20 patients with portal hypertension. ability flowmetry detect changes venous after an intravenous dose 2 mg terlipressin evaluated 13 double-blind, randomized, placebo-controlled, cross-over design.The correlated significantly (R=0.81, P < 0.001)....
Abstract Background and study aims Transgastric endoscopic ultrasound (EUS)-guided drainage and, if needed, necrosectomy is the preferred treatment in patients with pancreatic walled-off necrosis. EUS-guided transcolonic or transrectal may serve as a minimally invasive alternative cases which transgastric percutaneous either impossible fails to secure sufficient drainage. In this paper, we retrospectively evaluated feasibility, safety, efficacy of treatment. We included nine found technical...
Aims Walled-off necrosis (WON) extending to the paracolic gutters or pelvic cavity may pose a significant challenge for drainage and necrosectomy. We aim report our technical experience clinical outcomes in manageing WONs with an EUS-guided transrectal/transcolonic (TR/TC) approach.
The effects on plasma angiotensin‐converting enzyme activity and renin of the two long‐acting inhibitors, lisinopril enalapril, alone in combination with propranolol were studied. In an open, randomised, cross‐over design 12 healthy volunteers received orally enalapril 20 mg alone, 80 mg, mg. Plasma measured for 24 h after each treatment period. Lisinopril reduced angiotensin converting substantially equally at six hr (–70%, P<0.05) (–65%, P<0.05), irrespective propranolol. At remained...