A5101764673- Gastroesophageal reflux and treatments
- Aldose Reductase and Taurine
- Drug Transport and Resistance Mechanisms
- Gastrointestinal motility and disorders
- Clinical Nutrition and Gastroenterology
- Prenatal Substance Exposure Effects
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Shoulder Injury and Treatment
- Veterinary Equine Medical Research
- Biochemical effects in animals
- Liver Disease and Transplantation
- Diet and metabolism studies
- Analytical Chemistry and Chromatography
- Thermoregulation and physiological responses
- Protein Interaction Studies and Fluorescence Analysis
- Cardiac electrophysiology and arrhythmias
- Voice and Speech Disorders
- Biochemical Acid Research Studies
- Microscopic Colitis
- Dietary Effects on Health
- Tendon Structure and Treatment
- Exercise and Physiological Responses
- Birth, Development, and Health
Copenhagen University Hospital
2001-2024
Rigshospitalet
2006-2024
University of Copenhagen
2013-2024
Novo Nordisk (Denmark)
1995-2002
University of Bonn
1997
In a Norwegian, prospective study we investigated breast cancer risk in relation to age at, and time since, childbirth, whether the timing of births modified pattern after delivery. A total 23 890 women parity 5 or less were diagnosed with during follow-up 1.7 million at ages 20–74 years. Results, based on Poisson regression analyses person-years risk, showed long-term protective effects first, as well subsequent, pregnancies that these preceded by short-term increase risk. The magnitude...
Summary Background Elevated serum bile acids (BA) are harmful to the heart and alterations in BA composition have been suggested cause cardiovascular disturbances cirrhosis. Aim To investigate any associations between specific groups or individual structural functional cardiac abnormalities patients with Methods An explorative study 86 All participants underwent extensive assessment, including MRI quantification of myocardial extracellular volume (ECV), which is indicative diffuse fibrosis....
Summary Background Bile acid diarrhoea is often missed because gold standard nuclear medicine tauroselcholic [75‐Se] (SeHCAT) testing has limited availability. Empirical treatment effect unknown diagnostic performance, whereas plasma 7α‐hydroxy‐4‐cholesten‐3‐one (C4) inexpensive but lacks sensitivity. Aims To determine characteristics of empirical and explore improvements in diagnostics with potential better availability than SeHCAT. Methods This accuracy study was part a randomised,...
INTRODUCTION: Both liraglutide and colesevelam improve bile acid diarrhea symptoms. Colesevelam binds excess amounts of diarrhea-causing acids in the colon, whereas mode action for remains elusive. In this article, we examined impact treatment on concentrations serum feces fecal microbiota composition to better understand 2 drugs' modes action. METHODS: Bile species were analyzed samples from a randomized, double-blind, double-dummy trial at baseline after 3 6 weeks orally administered...
Infants with neonatal cholestasis are prone to neurodevelopmental deficits, however, the underlying pathogenesis is unclear. Lipid malabsorption and accumulation of potentially neurotoxic molecules in blood such as bile acids important yet relatively unexplored pathways. Here, we developed a translational piglet model understand how molecular acid lipid composition brain affected by this disease relates motor function. Piglets (8-days old) had duct ligation or sham surgery were fed formula...
The gut-liver axis and enterohepatic circulation have gained increasing attention lately. Patients with short bowel syndrome (SBS) are, in fact, human knock-out models that may assist the understanding of bile acid synthesis regulation. We evaluated effect glepaglutide (a long-acting glucagon-like peptide-2 analog) on (the acids liver biochemistry patients SBS).In a single-center, double-blinded, dose-finding, crossover phase 2 trial, 18 SBS were randomly assigned to 3 treatment arms (0.1,...
Abstract Objectives The direct oral anticoagulants ( DOAC s), apixaban and rivaroxaban, are used for anticoagulation treatment. Although biochemical monitoring is not required, severe bleedings caused by have been reported. We therefore evaluated the chromogenic assay Biophen DiXaI ® (Biophen) using plasma from non‐bleeding patients in treatment with on spiked ongoing bleeding. Methods method was compared an in‐house reference method; liquid chromatography‐tandem mass spectrometry LC ‐ MS /...
To date, the intraindividual reproducibility of fasting and postprandial gallbladder (GB) volumes has not been established satisfactorily. Hence we examined variability GB motility, using biplane Simpson method as a new sonographic tool for volume determination.The was validated in vitro vivo compared with sum-of-cylinders method. Thereafter, emptying after defined test meal 10 healthy volunteers over 108 min on days 1, 31, 61.The results correlated real (r = 0.99) provided intra-...
Abstract Design The hormone secretin, best known for regulating pH in the duodenum, has anorectic properties mice proposedly mediated via secretin-induced brown adipose tissue (BAT) activation. We investigated effects of exogenous secretin on ad libitum food intake, BAT activity, and postprandial physiology healthy male volunteers. Methods In a randomized, placebo-controlled, double-blind, crossover study, 25 men underwent two 5-hour i.v. infusions (1 pmol/kg/min) placebo (saline),...
Abstract The effects of two inhibitors hepatic glucose production, AICAR (5‐aminoimidazole‐4‐carboxamide riboside) and metformin, whose precise mechanisms action are a matter some controversy, have been investigated in isolated rat hepatocytes by application novel NMR‐based method whereby on metabolic flow from the glucose‐producing pathways, glycogenolysis gluconeogenesis, also lactate can be studied simultaneously. Hepatocytes were pre‐incubated for 24 h with 15 m M 1‐ 13 C‐glucose to load...
Summary A 9‐year‐old donkey jenny (212 kg) presented with an acute, nonweight‐bearing left forelimb lameness of 24‐ to 36‐h duration. The limb was held in flexion and abduction, the toe above ground, unable be manually straightened. There significant palpable swelling along medial aspect elbow joint. Radiographic evaluation revealed a luxation joint rupture collateral ligament. Closed reduction accomplished under injectable anaesthesia without complication. patient weight‐bearing comfortable...