A5031533033- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Complement system in diseases
- Gallbladder and Bile Duct Disorders
- Drug-Induced Hepatotoxicity and Protection
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Inflammation biomarkers and pathways
- Drug Transport and Resistance Mechanisms
- Organ Transplantation Techniques and Outcomes
- Glycosylation and Glycoproteins Research
- Microscopic Colitis
- Immunotherapy and Immune Responses
- Pediatric Hepatobiliary Diseases and Treatments
- Ergonomics and Musculoskeletal Disorders
- T-cell and B-cell Immunology
- Lymphatic System and Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Dermatological and COVID-19 studies
Hvidovre Hospital
2006-2025
University of Copenhagen
2010-2025
ERN GUARD-Heart
2020-2025
ERN RARE-LIVER
2020-2025
Copenhagen University Hospital
2022-2024
Rigshospitalet
2005-2023
Hospital de São João
2023
King's College Hospital
2022
Glostrup Hospital
1996
Histologic scoring systems specific for primary sclerosing cholangitis (PSC) are not validated. We recently determined the applicability and prognostic value of three histological in a single PSC cohort. The aim this study was to validate their use reproducibility across multicenter Liver biopsies from patients were collected seven European institutions. performed using Nakanuma, Ishak, Ludwig systems. Biopsies independently scored by six liver pathologists interobserver agreement. clinical,...
Background & AimsGut-homing lymphocytes that express the integrin α4β7 and CCR9 might contribute to development of primary sclerosing cholangitis (PSC). Vedolizumab, which blocks α4β7, is used treat patients with inflammatory bowel diseases (IBD), but there are few data on its efficacy in PSC. We investigated effects vedolizumab a large international cohort PSC IBD.MethodsWe collected from European North American centers participating International Study Group IBD who received at least 3...
Background. There are no earlier cross-national comparative studies analyzing the functioning of posture control mechanisms and its sensory-motor correlates in elderly subjects. We investigated whether there differences balance between subjects living different geographical areas, analyzed associates men women separately. Method. Using a force platform method, system under three standardized conditions (normal standing, eyes open; normal closed; tandem open) was studied among samples...
Inflammatory bowel disease (IBD) may be complicated by primary sclerosing cholangitis (PSC). We aimed to assess the characteristics of Danish PSC-IBD patients and compare their prognosis with IBD without PSC.A retrospective nationwide population-based cohort 257 was assessed through national registries manual scrutiny patient files.For all diagnosed after 1976 (n = 222) 8231 controls (ie, PSC), cumulative probability resective surgery, liver transplantation, cancer, survival from 1977 2011...
Not all patients with autoimmune hepatitis (AIH) respond to standard medical therapy corticosteroids and azathioprine. Such may develop end-stage liver disease poor prognosis unless transplantation is considered. Alternatively, the introduction of new therapeutic strategies could potentially ameliorate deterioration function. Patients in our tertiary center were selected for everolimus when exhibiting nonresponse or intolerance combinations empirical drugs use (e.g., mycophenolate mofetil,...
Background and aims Alcoholic hepatitis (AH) is characterized by acute liver failure, neurocognitive impairment renal failure. Severe inflammatory reactions are also known to occur in AH. Inflammation bacterial translocation the gut thought have major impact on disease development progression. The mortality rate for AH close 50%. We aimed assess efficacy of rifaximin treating its inflammation metabolism. Methods trial was approved relevant authorities (EudraCT no: 2014-02264-33, Scientific...
Background: Postoperative bacterial infectious complications are frequent in patients with colorectal cancer (CRC), subsequent increased recurrence rates and poor prognosis. Deficiency of the mannan‐binding lectin (MBL) complement activation pathway may cause risk infection certain patient groups. It is hypothesized that a deficient MBL might be more among CRC than healthy individuals. The was therefore evaluated serum obtained preoperatively from 193 primary 150 volunteers. Methods: Serum...
Abstract Mannan‐binding lectin (MBL) and MBL‐associated serine protease 2 (MASP‐2) are central components of the MBL pathway complement activation, may have potential as clinical biomarkers in colorectal cancer (CRC). Prior to usage, knowledge biological variations molecules is needed. We here investigate MASP‐2 healthy persons over time relation gender, age physical activity. concentrations were determined serum from adults a 3‐week period this was repeated 6 months later ( n = 32); during...
<i>Background/Aims:</i> Sweet’s syndrome (SS) is a severe dermatosis that may be an extraintestinal manifestation of inflammatory bowel disease (IBD). Worldwide, 35 cases SS associated with IBD have been reported. We present the first case severe, recurrent in combination amebic infection and ulcerative colitis complicated multiple other manifestations. <i>Methods:</i> Disease course was monitored by serum YKL-40 C-reactive protein (CRP), white blood cell count,...
INTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed risk prediction in PBC, but these not validated large external cohorts. METHODS: We performed study data of 1746 UDCA-treated PBC from 25 centers Europe, United States, Canada. The prognostic performance the (GLOBE UK-PBC) (Barcelona, Paris I,...
Summary Background Elevated serum bile acids (BA) are harmful to the heart and alterations in BA composition have been suggested cause cardiovascular disturbances cirrhosis. Aim To investigate any associations between specific groups or individual structural functional cardiac abnormalities patients with Methods An explorative study 86 All participants underwent extensive assessment, including MRI quantification of myocardial extracellular volume (ECV), which is indicative diffuse fibrosis....
The European Reference Network on Hepatological Diseases (ERN RARE-LIVER) launched the prospective, multicentre, quality-controlled R-LIVER registry rare liver diseases. aim of this study was to assess presentation and outcome autoimmune hepatitis (AIH) after 1 year treatment.
Abstract Background and aims Between 5-10% of patients with inflammatory bowel disease (IBD) will eventually be diagnosed primary sclerosing cholangitis (PSC) [1,2]. Studies suggest that a significant number IBD may have PSC despite lacking biochemical or clinical signs, leading to delayed diagnosis. Sometimes, the liver is identified only after severe complications malignancy developed. This highlights need for improved diagnostic markers identify individuals at high risk developing [3]....
Background: Impaired health-related quality of life (HRQoL) contributes to the overall disease burden in autoimmune hepatitis (AIH). This study aimed evaluate HRQoL people with AIH and identify potentially modifiable factors associated impaired using validated patient-reported outcome measures. Methods: Adult patients diagnosed at 12 European centers were enrolled this prospective, cross-sectional from July 2020-June 2023. was assessed Physical Component Score (PCS) Mental (MCS) 12-item...
Abstract Purpose: Mannan-binding lectin-associated serine protease 2 (MASP-2) is a plasma protein involved in inflammatory processes. MASP-2 circulates complex with the mannan-binding lectin (MBL) or ficolins, and activated to recruit complement system when MBL binds its targets. The level of genetically determined, aim present study was evaluate effect levels on postoperative infection, recurrence survival. Experimental Design: concentrations were determined serum from 605 patients...
Summary The mannan-binding lectin (MBL) pathway of complement activation is important in host defence against pathogens and possibly cancer. We investigated the effect major surgery on two central components MBL pathway; MBL-associated serine protease MASP-2, for comparison also measured interleukin (IL)-6 C-reactive protein (CRP) levels. Serial blood samples were obtained from patients belonging to different cohorts. Cohort 1 comprised 60 undergoing open or laparoscopic colectomy benign...
Acute liver failure (ALF) is rare but life-threatening. Common causes include intoxications, infections, and metabolic disorders. Indeterminate etiology still frequent. No systematic data on incidence, causes, outcome of ALF across Europe are available. Via an online survey we reached out to European Reference Network Centers diseases. Numbers cases during 2020 were retrieved diagnostic treatment availabilities assessed. In total, 455 (306 adult, 149 pediatric) reported from 36 centers 20...
Patients with autoimmune liver disease but without overt diabetes display glucose disturbances early on in their course. We identified pathophysiological traits specific to these patients including altered incretin responses.