A5006933426- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Celiac Disease Research and Management
- Liver physiology and pathology
- Systemic Sclerosis and Related Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- SARS-CoV-2 and COVID-19 Research
- Engineering Technology and Methodologies
- Endoplasmic Reticulum Stress and Disease
- Air Quality and Health Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Diabetes and associated disorders
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Systemic Lupus Erythematosus Research
- COVID-19 Impact on Reproduction
- Pancreatitis Pathology and Treatment
- Electrolyte and hormonal disorders
- Myasthenia Gravis and Thymoma
Medical University of Warsaw
2015-2025
ERN RARE-LIVER
2020-2025
ERN GUARD-Heart
2019-2025
Universität Hamburg
2025
University Medical Center Hamburg-Eppendorf
2025
Łukasiewicz Research Network
2023
Saarland University
2019
University Medical Center
2019
SGH Warsaw School of Economics
2016
Background and Aims: A limited number of drugs are used as standard or alternative therapies in autoimmune hepatitis (AIH). No specific recommendations available for patients failing to respond these therapies. We analyzed the efficacy safety infliximab with AIH. Approach Results: performed a retrospective study 42 AIH who received at 21 liver centers 12 countries. Patients were categorized according reason therapy. group 1 (n=20) had failed standard, second-line (mycophenolate mofetil...
Abstract Background and Aims Autoimmune hepatitis is a progressive chronic liver disease. Health‐related quality of life in autoimmune has not attracted much attention so far. We prospectively assessed various aspects health‐related well characterized group patients with hepatitis. Methods In total, 140 (mean age 40 ± 17 years) 170 controls 36 14 were included. was evaluated following questionnaires: The Short Form (36) Health Survey, Modified Fatigue Impact Score, State‐Trait Anxiety...
Abstract Background and Aims Detection of autoantibodies is a mainstay diagnosing autoimmune hepatitis (AIH). However, conventional for the workup AIH lack either sensitivity or specificity, leading to substantial diagnostic uncertainty. We aimed identify more accurate serological markers with protein macroarray. Approach Results During search more‐precise distinguish from non‐AIH liver diseases (non‐AIH‐LD), IgG antibodies binding capacities many human foreign proteins were identified...
The European Reference Network on Hepatological Diseases (ERN RARE-LIVER) launched the prospective, multicentre, quality-controlled R-LIVER registry rare liver diseases. aim of this study was to assess presentation and outcome autoimmune hepatitis (AIH) after 1 year treatment.
Background: Impaired health-related quality of life (HRQoL) contributes to the overall disease burden in autoimmune hepatitis (AIH). This study aimed evaluate HRQoL people with AIH and identify potentially modifiable factors associated impaired using validated patient-reported outcome measures. Methods: Adult patients diagnosed at 12 European centers were enrolled this prospective, cross-sectional from July 2020-June 2023. was assessed Physical Component Score (PCS) Mental (MCS) 12-item...
Abstract Background and Aims Liver stiffness measurements (LSM), commonly performed by transient elastography (TE) or two‐dimensional shear wave (2D‐SWE), are used to quantify liver fibrosis. Active hepatitis, a hallmark of autoimmune hepatitis (AIH), could bias LSM. This might be overcome measurement spleen 2D‐SWE. Here, we compare 2D‐SWE TE biopsy (LB) in prospectively recruited patients with AIH. Methods We analysed relation 90 treated ≥ 6 months for were also compared LB 63 individuals...
BACKGROUND In living donor liver transplantation (LDLT), 2 patients undergo surgery, and the advantages disadvantages for both should be considered. This study evaluated long-term quality of life in donors, its impact on their activities daily focusing mood mental health. MATERIAL AND METHODS total, 101 donors (69 female 32 male patients, median age 36.8 years) were surveyed at a time 61.8 months after donation (range 7-169 months). The generic Short Form Health Survey (SF-36), Patient...
There is little data on the hepatic efficacy and safety of immunomodulatory drugs used in patients with autoimmune hepatitis (AIH), despite their established use dermatology, rheumatology inflammatory bowel diseases (IBD). Our aim was to collect real-life experience expert centres treating AIH these drugs, considered unconventional for management.
The clinical picture of autoimmune hepatitis (AIH) varies markedly between patients, potentially due to genetic modifiers. aim this study was evaluate variants previously associated with fatty liver as potential modulators the AIH phenotype. cohort comprised 313 non-transplanted adults AIH. In all MARC1 (rs2642438), HSD17B13 (rs72613567), PNPLA3 (rs738409), TM6SF2 (rs58542926), and MBOAT7 (rs641738) were genotyped using TaqMan assays. Mitochondrial damage markers in serum analyzed relation...
Autoimmune liver diseases (AILDs) are associated with impaired health-related quality of life (HrQoL). The aim this project was to identify potentially modifiable factors related HrQoL in a large transnational cohort patients AILDs.A cross-sectional online survey conducted on autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) or sclerosing from 15 European countries. measured EQ-5D-5L and EQ visual analogue scale (EQ-VAS) analysed relation demographic, psychosocial, disease-...
Gamma Knife (GK) radiosurgery for pediatric arteriovenous malformations (AVM) of the brain presents a non-invasive treatment option. We report our institutional experience with GK AVMs.We performed retrospective review all patients treated cerebral AVMs at institution from November 2003 up to and including September 2014. Patient demographics, AVM characteristics, parameters responses were recorded.Nineteen treated, 4 lost follow-up. The mean age was 14.2 years (range. 7-18 years), 10 being...
Vitamin D deficiency has been associated with depressive symptoms and reduced physical functioning. The aim of the study was to characterize relationship between polymorphisms vitamin receptor (VDR) gene quality life in patients autoimmune hepatitis (AIH) primary biliary cholangitis (PBC). Three VDR (TaqI-rs731236, BsmI-rs1544410, ApaI-rs7975232) were analyzed AIH (n = 142) PBC 230) healthy individuals 376). Patient assessed by validated questionnaires such as Medical Outcomes Study...
Optimizing patients’ condition before liver transplantation (LT) could potentially improve survival of LT patients. We focused on sarcopenia, as a common factor in transplant candidates that can impact their cardiopulmonary performance at the point listing, morbidity, and mortality after LT. performed single-center cohort study 98 consecutive patients with cirrhosis who were transplanted between March 2015 December 2017. The third lumbar vertebra skeletal muscle index (L3SMI) was calculated...