Vincenzo Ronca
A5039516089- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis Viruses Studies and Epidemiology
- Drug Transport and Resistance Mechanisms
- Organ Donation and Transplantation
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Macrophage Migration Inhibitory Factor
- Robotics and Automated Systems
- Renal Diseases and Glomerulopathies
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Lymphoblastic Leukemia research
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Venous Thromboembolism Diagnosis and Management
IRCCS Humanitas Research Hospital
2024-2025
University of Birmingham
2020-2025
ERN GUARD-Heart
2025
Humanitas University
2015-2025
NIHR Birmingham Biomedical Research Centre
2021-2025
Universität Hamburg
2025
University Medical Center Hamburg-Eppendorf
2025
Radboud University Nijmegen
2025
Radboud University Medical Center
2025
Medical University of Warsaw
2025
•Under real-world conditions, OCA was effective in ~43% of patients who were non-responders to UDCA, according Poise criteria.•Patients with cirrhosis showed lower efficacy (29.5%), mainly attributed reduced tolerability and higher discontinuation rate.•Patients overlap AIH-PBC a comparable pure PBC, ALT reduction at 6 months.•Most PBC are still need additional therapy if aiming normalise liver biochemistry. Background & aimsObeticholic acid (OCA) is the second-line treatment approved for...
In autoimmune hepatitis, achieving complete biochemical remission (CBR) with current weight-based thiopurine dosing is challenging. We investigated whether patients could be stratified regarding CBR according to a target range of metabolites. Moreover, we explored the effects azathioprine dosage increases and co-therapy allopurinol low-dose thiopurines on metabolite profiles treatment response.
Abstract The presence of CD8 + T cells in the cytoplasm biliary epithelial (BEC) has been correlated with damage associated primary cholangitis (PBC). Here, we characterise mechanism cell invasion into BEC. observed within BEC were large, eccentric, and expressed E-cadherin, CD103 CD69. They also not contained secondary vesicles. Internalisation required cytoskeletal rearrangements which facilitated contact Internalised both non-cirrhotic cirrhotic diseased liver tissues but enriched PBC...
Background and Aims Liver fibrosis holds a relevant prognostic meaning in primary biliary cholangitis (PBC). Noninvasive evaluation using vibration‐controlled transient elastography (VCTE) is routinely performed. However, there limited evidence on its accuracy at diagnosis PBC. We aimed to estimate the diagnostic of VCTE assessing advanced (AF) disease presentation Approach Results collected data from 167 consecutive treatment‐naïve PBC patients who underwent liver biopsy (LB) six Italian...
Primary Biliary Cholangitis (PBC) is a chronic cholestatic liver disease characterized by the progressive destruction of intrahepatic bile ducts, leading to fibrosis, and potentially cirrhosis. PBC has been considered prototypical autoimmune condition, given presence specific autoantibodies immune response against well-defined mitochondrial autoantigens. Further evidence supports interaction immunogenetic environmental factors in aetiology PBC. An immunological attack on biliary epithelial...
The presented work aimed to investigate neurophysiological markers of sense presence in virtual reality. study was based on developing and preliminary validating a -based approach for evaluation. A VR environment designed modulate multisensory conditions, including visual, auditory, vibrotactile stimuli. EEG, ECG, EDA signals were recorded. Mutual Information-based index (SoPMI) developed as synthetic metric presence, integrating multiple physiological signals. Signal preprocessing analysis...
Background: Impaired health-related quality of life (HRQoL) contributes to the overall disease burden in autoimmune hepatitis (AIH). This study aimed evaluate HRQoL people with AIH and identify potentially modifiable factors associated impaired using validated patient-reported outcome measures. Methods: Adult patients diagnosed at 12 European centers were enrolled this prospective, cross-sectional from July 2020-June 2023. was assessed Physical Component Score (PCS) Mental (MCS) 12-item...
Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) "advanced cirrhosis" because of its narrow therapeutic index. We aimed to better define the predicting factors hepatic serious adverse events (SAEs) and non-response cirrhotic undergoing OCA therapy.Safety efficacy treatment were evaluated a cohort consecutive PBC started OCA. response was according Poise criteria. Risk for SAEs reported as risk ratios (RR) 95% confidence intervals...