A5014172694- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Microscopic Colitis
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Platelet Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Gastrointestinal motility and disorders
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
Ospedale Policlinico San Martino
2016-2025
University of Genoa
2016-2025
Yale University
2023-2024
National Yang Ming Chiao Tung University
2020-2023
Taipei Veterans General Hospital
2020-2023
Imperial College London
2020-2023
Humanitas University
2020-2023
European Association for the Study of the Liver
2022
The Geneva Association
2022
University of Pisa
2020
Cirrhotic patients frequently undergo screening endoscopy for the presence of oesophageal varices (OV). In future, this social and medical burden will increase due to greater number with chronic liver disease their improved survival. study, our aims were (1) identify clinical, biochemical, ultrasonographic parameters which might non-invasively predict OV in cirrhosis; (2) evaluate reproducibility obtained results a different, although related, further group patients; (3) assess...
The aspartate aminotransferase-alanine aminotransferase ratio (AST/ALT ratio) has been used to noninvasively assess the severity of disease in patients with chronic liver (CLD). We previously demonstrated that progressive functional impairment is associated an increase AST/ALT ratio.To evaluate reproducibility and transportability a large cohort different degrees hepatitis C virus (HCV)-related CLD, confirm correlation between function ratio, whether diagnostic accuracy ALT/AST can be...
Eltrombopag is an oral thrombopoietin-receptor agonist. This study evaluated the efficacy of eltrombopag for increasing platelet counts and reducing need transfusions in patients with thrombocytopenia chronic liver disease who are undergoing elective invasive procedure.
The prognosis of untreated patients with hepatocellular carcinoma (HCC) is heterogeneous, and survival data were mainly obtained from control arms randomized studies. Clinical practice on this topic are urgently needed, so as to help plan studies counsel patients. We assessed the 600 HCC managed by Italian Liver Cancer Group. Prognosis was evaluated subdividing according Barcelona Clinic (BCLC) classification. also main demographic, clinical, oncological determinants in subgroup advanced...
Background Modulation of adaptive immunity may underscore the efficacy trans-arterial chemoembolization (TACE). We evaluated influence TACE on T-cell function by phenotypic lymphocyte characterization in samples patients undergoing surgery with (T+) or without (T-) prior-TACE treatment. Methods profiled intratumoral (IT), peritumoral (PT) and non-tumoral (NT) background tissue to evaluate regulatory CD4+/FOXP3+ (T-reg) immune-exhausted CD8+/PD-1+ T-cells across T+ (n=58) T− (n=61). performed...
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum diseases associated to metabolic disorders. The main objective this study was compare patients with MAFLD and non-MAFLD hepatocellular carcinoma (HCC) included in nationally representative cohort.We analysed 6882 consecutive HCC enrolled from 2002 2019 by 23 Italian Liver Cancer centres epidemiological future trends three subgroups: pure, single aetiology (S-MAFLD); mixed...
BACKGROUND AND AIMS Noninvasive assessment of esophageal varices (EV) may improve the management patients with cirrhosis and decrease both medical financial burden related to screening. In this multicenter, international study, our aim was prospectively validate use platelet count/spleen diameter ratio for noninvasive diagnosis EV. METHODS A total 218 cirrhotic underwent screening endoscopy Platelet ((N/mm3)/mm) assessed in all its diagnostic accuracy calculated. On basis previous results, a...
Patients with hepatocellular carcinoma should be managed a multidisciplinary approach framed in network where all the diagnostic techniques and therapeutic resources are available order to provide optimal level of care. Given this assumption, Coordinating Committee Italian Association for Study Liver nominated panel experts elaborate practical recommendations management aiming provide: (1) homogeneous efficacious staging work-up, (2) best treatment choice tailored patient status tumour stage...
<h3>Objectives</h3> The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) is expected to increase. We compared the presenting features and outcome HCC in (≥70 years) younger (<70 years). <h3>Design</h3> Multicentre retrospective cohort study nested case–control study. <h3>Patients</h3> 614 1104 from ITA.LI.CA database, including 1834 cases consecutively January 1987 December 2004. Both groups were stratified according treatment: hepatic resection, percutaneous...
Alpha-fetoprotein is a tumor marker that has been used for surveillance and diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. The prognostic capability this HCC not clearly defined. In study our aim was to evaluate the usefulness serum alpha-fetoprotein well-compensated cirrhosis, optimal performance status, small identified during periodic ultrasound who were treated curative intent. Among 3,027 included Italian Liver Cancer group database, we selected 205 Child-Pugh...
Background Prognostic assessment in patients with hepatocellular carcinoma (HCC) remains controversial. Using the Italian Liver Cancer (ITA.LI.CA) database as a training set, we sought to develop and validate new prognostic system for HCC. Methods Findings Prospective collected databases from Italy (training cohort, n = 3,628; internal validation 1,555) Taiwan (external 2,651) were used ITA.LI.CA system. We first defined stages (0, A, B1, B2, B3, C) using only tumor characteristics (largest...