Nao Nishida
A5102751242- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Genetic Associations and Epidemiology
- Pediatric Hepatobiliary Diseases and Treatments
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Genetics and Neurodevelopmental Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Osteoarthritis Treatment and Mechanisms
- Gene expression and cancer classification
- Genetic diversity and population structure
- Pacific and Southeast Asian Studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Chronic Lymphocytic Leukemia Research
- Genomic variations and chromosomal abnormalities
- Viral Infections and Immunology Research
- Bioinformatics and Genomic Networks
National Center for Global Health and Medicine
2015-2024
Center for Global Health
2016-2024
Tokyo Medical and Dental University
2023-2024
The University of Tokyo
2013-2023
Osaka University
2014
Fujita Health University
2014
Teikyo University
2014
University of Occupational and Environmental Health Japan
2014
Nagoya University
2014
Bunkyo University
2012-2013
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across continent remains enigmatic. Here we report a large-scale survey autosomal from broad sample Asian human populations. Our results show that ancestry is strongly correlated with affiliations as well geography. Most populations relatedness within ethnic/linguistic groups, despite prevalent gene flow among More than 90% East (EA) haplotypes could be found in either Southeast...
The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-λ3, which has antiviral effects, is known chronic HCV but not HBV infection. Thus, we measured IFN-λ3 levels patients with and investigated its association nucleos(t)ide (NUC) analogue administration.Serum level was 254 varying conditions using our own high sensitivity method. resulting values were compared various variables. In addition, cell lines originating from organs cultured NUCs,...
Hepatitis B virus (HBV) infection can lead to serious liver diseases, including cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85–90% of infected individuals become inactive carriers with sustained biochemical remission very low risk LC or HCC. To identify host genetic factors contributing HBV clearance, we conducted genome-wide association studies (GWAS) replication analysis using samples from spontaneously HBV-resolved Japanese Korean individuals. Association in the data...
To elucidate the molecular mechanism underlying endochondral ossification process during skeletal growth and osteoarthritis (OA) development, we examined signal network around CCAAT/enhancer-binding protein-β (C/EBPβ, encoded by CEBPB), a potent regulator of this process. Computational predictions C/EBP motif-reporter assay identified RUNX2 as most transcriptional partner C/EBPβ in chondrocytes. were induced co-localized highly differentiated chondrocytes OA development mice humans. The...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing disease 2019 (COVID-19) was announced as an outbreak by World Health Organization (WHO) in January 2020 and a pandemic March 2020. The majority of infected individuals have experienced no or only mild symptoms, ranging from fully asymptomatic cases to pneumonic disease. However, minority develop severe symptoms. objective this study identify susceptible HLA alleles clinical markers that can be used risk...
Elucidation of the genetic susceptibility factors for diabetic retinopathy (DR) is important to gain insight into pathogenesis DR, and may help define risk this condition. In present study, we conducted a three-stage genome-wide association study (GWAS) identify DR loci in Japanese patients, which comprised total 837 type 2 diabetes patients with (cases) 1,149 without (controls). From stage 1 scan 446 subjects (205 cases 241 controls) on 614,216 SNPs, 249 SNPs were selected replication 623...
Hematologic abnormalities during current therapy with pegylated interferon and ribavirin (PEG-IFN/RBV) for chronic hepatitis C (CHC) often necessitate dose reduction premature withdrawal from therapy. The aim of this study was to identify host factors associated IFN-induced thrombocytopenia by genome-wide association (GWAS). In the GWAS stage using 900K single-nucleotide polymorphism (SNP) microarrays, 303 Japanese CHC patients treated PEG-IFN/RBV were genotyped. One SNP (rs11697186) located...
Human presence in Southeast Asia dates back to at least 40,000 years ago, when the current islands formed a continental shelf called Sundaland. In Philippine Islands, Peninsular Malaysia, and Andaman there exist indigenous groups collectively Negritos whose ancestry can be traced "First Sundaland People." To understand relationship between these Negrito their demographic histories, we generated genome-wide single nucleotide polymorphism data compared them with existing from other...
Culture evolves in ways that are analogous to, but distinct from, genomes. Previous studies examined similarities between cultural variation and genetic (population history) at small scales within language families, few have empirically investigated these parallels across families using diverse data. We report an analysis comparing culture genomes from around northeast Asia spanning 11 families. extract summarize the (grammar, phonology, lexicon), music (song structure, performance style),...