A5014161783- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Viral Infections and Immunology Research
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- interferon and immune responses
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
Kanazawa University Hospital
2016-2025
Kanazawa University
2016-2025
Kyoto University
2021
Kanazawa Medical University
2009-2020
Takara (Japan)
2020
The Japanese Society of Gastroenterological Surgery
2016
Hospital de Santa Maria
2015
Centro Hospitalar Lisboa Norte
2015
Nihon University
1995-2013
Kindai University
2012
Recently, nonalcoholic steatohepatitis (NASH) was found to be correlated with cardiovascular disease events independently of the metabolic syndrome. The aim this study investigate whether an atherogenic (Ath) diet induces pathology necessary for diagnosis human NASH and how cholesterol triglyceride alter hepatic gene expression profiles responsible oxidative stress. We investigated liver plasma lipids mice fed Ath diet. profile examined microarrays real-time polymerase chain reactions....
Background and Aims: The aim of this study was to determine whether expression hepatitis C virus proteins alters hepatic morphology or function in the absence inflammation. Methods: Transgenic C57BL/6 mice with liver-specific RNA encoding complete viral polyprotein (FL-N transgene) structural (S-N were compared nontransgenic littermates for altered liver function. Results: FL-N transcripts detectable only by reverse-transcription polymerase chain reaction, S-N identified Northern blots....
MicroRNA (miRNA) plays an important role in the pathology of various diseases, including infection and cancer. Using real-time polymerase chain reaction, we measured expression 188 miRNAs liver tissues obtained from 12 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) 14 C (HCV)-related HCC, background normal nine patients. Global gene same was analyzed via complementary DNA microarray to examine whether differentially expressed could regulate their target genes....
Abstract Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer cells; CSCs). CSCs are considered pivotal target for the eradication cancer, and liver have been identified use various markers. However, little information known about expression patterns characteristics marker-positive CSCs, hampering development personalized CSC-targeted therapy. Here, we show CSC markers EpCAM CD90 independently expressed in cancer. In...
OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) is a phenotype of type 2 diabetes and obesity. Currently, the efficacy sodium–glucose cotransporter (SGLT2) inhibitors sulfonylureas in pathology hepatic gene expression profiles for with NAFLD are unknown. RESEARCH DESIGN AND METHODS We conducted 48 week, randomized, open-label, parallel-group trial involving participants biopsy-confirmed NAFLD. A total 40 were randomly assigned to receive once daily 20 mg tofogliflozin or 0.5 glimepiride....
The replication and infectivity of the lipotropic hepatitis C virus (HCV) are regulated by cellular lipid status. Among differentially expressed microRNAs (miRNAs), we found that miR-27a was preferentially in HCV-infected liver over B (HBV)-infected liver. Gene expression profiling Huh-7.5 cells showed regulates metabolism targeting synthetic transcription factor RXRα transporter ATP-binding cassette subfamily A member 1. In addition, repressed many metabolism-related genes, including FASN,...
Many tumor-associated antigens (TAAs) recognized by cytotoxic T cells (CTLs) have been identified during the last two decades and some of them used in clinical trials. However, there are very few field immunotherapy for hepatocellular carcinoma (HCC) because not comparative data regarding CTL responses to various TAAs. In present study, using 27 peptides derived from 14 different TAAs, we performed analysis TAA-specific T-cell 31 HCC patients select useful examined factors that affect immune...
The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-λ3, which has antiviral effects, is known chronic HCV but not HBV infection. Thus, we measured IFN-λ3 levels patients with and investigated its association nucleos(t)ide (NUC) analogue administration.Serum level was 254 varying conditions using our own high sensitivity method. resulting values were compared various variables. In addition, cell lines originating from organs cultured NUCs,...
Hepatitis B virus (HBV) infection can lead to serious liver diseases, including cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85–90% of infected individuals become inactive carriers with sustained biochemical remission very low risk LC or HCC. To identify host genetic factors contributing HBV clearance, we conducted genome-wide association studies (GWAS) replication analysis using samples from spontaneously HBV-resolved Japanese Korean individuals. Association in the data...
Persistent infections with hepatitis B virus (HBV) or C (HCV) account for the majority of cases hepatic cirrhosis and hepatocellular carcinoma (HCC) worldwide. Small, non-coding RNAs play important roles in virus-host interactions. We used high throughput sequencing to conduct an unbiased profiling small (14-40 nts) liver from Japanese subjects advanced (HCC). Small derived tRNAs, specifically 30–35 nucleotide-long 5′ tRNA-halves (5′ tRHs), were abundant non-malignant significantly increased...
Nonalcoholic fatty liver disease (NAFLD) is closely related to insulin resistance and lipid metabolism. Recent studies have suggested that the quality of fat accumulated in associated with development nonalcoholic steatohepatitis (NASH). In this study, we investigated acid composition tissue its association pathology NAFLD patients.One hundred three patients diagnosed [simple steatosis (SS): 63, NASH: 40] were examined their hepatic acids measured using gas chromatography. addition,...
Recent metagenomic analyses have revealed dysbiosis of the gut microbiota ulcerative colitis (UC) patients. However, impacts this are not fully understood, particularly at strain level.We perform whole-genome shotgun sequencing fecal DNA extracts from 13 healthy donors and 16 UC 8 Crohn's disease (CD) The CD patients is taxonomically functionally divergent that donors, with E. faecium being most differentially abundant species between two microbial communities. Transplantation feces or into...
The survival of patients with hepatocellular carcinoma (HCC) is often individually different even after surgery for early-stage tumors. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions regard vascularity and the activity organic anion transporter OATP1B3. Here we report that Gd-EOB-DTPA-enhanced MRI (EOB-MRI) in combination serum alpha-fetoprotein (AFP) status reflects...