A5031398294- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- IgG4-Related and Inflammatory Diseases
- Pancreatic and Hepatic Oncology Research
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Microscopic Colitis
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- Gastrointestinal Tumor Research and Treatment
Niigata University
2011-2021
Niigata University Medical and Dental Hospital
2007-2019
Creative Research Enterprises (United States)
2017
Kiel University
2011
Instituto de Ciencia y Tecnología de Alimentos y Nutrición
2011
National and Kapodistrian University of Athens
2011
University of Southern California
2001-2002
National Defense Medical College
1999
Abstract An elusive goal in transplanting organs across histocompatibility barriers has been the induction of specific tolerance to avoid graft rejection. A considerable body evidence exists that thymus produces regulatory T cells suppress response other antigenic stimulation. We report TGF-β can induce certain CD4+ naive (CD45RA+RO−) fraction human peripheral blood develop powerful, contact-dependent suppressive activity is not antagonized by anti-TGF-β or anti-IL-10 mAbs. The costimulatory...
Abstract Previously we reported that TGF-β has an important role in the generation and expansion of human “professional” CD4+CD25+ regulatory T cells periphery have a cytokine-independent mechanism action. In this study used low-dose staphylococcal enterotoxin to induce cell-dependent Ab production. We report induces activated CD4+CD25− become Th3 suppressor cells. While stimulating CD4+ with modestly increased expression CD25 intracellular CTLA-4 primary cultures, upon secondary stimulation...
In addition to the major intrathymic pathway of T cell differentiation, extrathymic pathways such differentiation have been shown exist in liver and intestine. particular, hepatic cells receptors or CD3 intermediate levels (i.e., receptor cells) always contain self-reactive clones sometimes appear at other sites, including target tissues autoimmune diseases tumor sites malignancies. To prove their origin self reactivity, this study we used thymectomized, irradiated (B6 x C3H/He) F1 mice...
Abstract We describe a novel therapeutic approach for cirrhosis using mesenchymal stem cells (MSCs) and colony-stimulating factor-1-induced bone marrow-derived macrophages (id-BMMs) analyze the mechanisms underlying fibrosis improvement regeneration. Mouse MSCs id-BMMs were cultured from mouse marrow their interactions analyzed in vitro. MSCs, id-BMMs, combination therapy administered to mice with CCl4-induced cirrhosis. Fibrosis regression, liver regeneration, liver-migrating host...
In Japan, bezafibrate (BF) is a second-line agent for primary biliary cholangitis (PBC) that refractory to ursodeoxycholic acid (UDCA) treatment. From retrospective cohort (n = 873) from the Japan PBC Study Group, we enrolled 118 patients who had received UDCA monotherapy at least 1 year followed by combination therapy with UDCA+BF year. GLOBE and UK-PBC scores after (i.e., immediately before therapy) were compared those of therapy. The real outcomes estimated Kaplan-Meier analysis predicted...
Mucosal-associated invariant T (MAIT) cells are innate-like involved in anti-bacterial immunity. Recent studies have demonstrated that MAIT might be implicated inflammatory bowel diseases (IBDs), but their precise function IBD remains to elucidated. We investigated the possible involvement of immunopathogenesis IBDs. Heparinized peripheral blood and biopsy specimens colon were collected from 25 patients with ulcerative colitis (UC), 15 Crohn’s disease (CD), 19 heathy individuals. Lymphocytes...
The impact of sarcopenia on the prognosis patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including arterial chemoembolization and infusion chemotherapy, remains unclear. We investigated prognostic value skeletal muscle loss (SML) stratified by cutoffs for rate change in mass over 6 months.We retrospectively evaluated 102 HCC treated therapies between 2005 2015. Computed tomography images third lumbar vertebra (L3) were analyzed to obtain area...
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we GWAS additional 1,923 (894 PBC 1,029 controls), combined the results with data. This GWAS, together a subsequent replication an independent set of 7,024 (512 6,512 PRKCB (rs7404928) novel locus (odds ratio [OR] = 1.26, P 4.13 ×...
Background and aim Among various symptoms accompanied with chronic liver disease, pruritus affects the quality of life patients, causing physical mental stress, worsens hepatic function. Recently, κ-opioid receptor agonist, nalfurafine hydrochloride was approved to treat central in patients disease Japan. This study aimed assess long-term efficacy safety on patients. Methods A patient-reported outcome using questionnaire-based methods used for 41 or without symptoms. Nalfurafine (2.5 μg/day)...
Background . Phosphorylated histone H2AX ( γ -H2AX) is a potential regulator of DNA repair and useful tool for detecting damage. To evaluate the clinical usefulness -H2AX in hepatocellular carcinoma (HCC), we measured level HCC, dysplastic nodule, nontumorous liver diseases. Methods The was by immunohistochemistry fifty-eight 18 chronic hepatitis, 22 cirrhosis, 19 nodules. Appropriate cases were also examined fluorescence analysis western blotting. Results All with disease showed increased...
The high heterogeneity of hepatocellular carcinomas (HCCs) complicates stratification HCC patients for treatment. Therefore, it is necessary to establish a comprehensive panel biomarkers related tumour behaviour and cancer prognosis. Resected HCCs from 251 were stained hepatic progenitor cell (HPC) markers epithelial adhesion molecule (EpCAM), neural (NCAM), delta-like 1 homolog (DLK1), cytokeratin 19 (CK19). Staining patterns analysed their prognostic association with relapse-free survival...
Aim: Previous studies have revealed that functional impairment of innate immune cells, including natural killer (NK) and T (NKT) might be associated with the persistence hepatitis C virus (HCV) infection. However, involvement which predominate in liver, therapeutic HCV clearance is still unclear. Methods: To clarify role intrahepatic cells clinical outcome patients chronic (CHC) treated interferon‐α plus ribavirin (IFN/RBV), we prospectively investigated status NK NKT paired liver biopsy...
Prognosis of patients with hepatocellular carcinoma (HCC) who undergo transcatheter intra-arterial therapies, including arterial chemoembolization and infusion chemotherapy, is affected by many clinical factors liver function tumor progression. However, the effect body composition such as skeletal muscle visceral subcutaneous adipose tissues (VAT SAT, respectively) on prognosis these remains unclear. We investigated prognostic value in HCC treated therapies.This study retrospectively...
Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified six susceptibility loci for PBC. Here, in order to further elucidate genetic architecture PBC, GWAS was performed on an additional independent sample set, then meta-analysis with our based whole-genome single nucleotide polymorphism (SNP) imputation analysis total 4,045 Japanese...