A5080215605- IgG4-Related and Inflammatory Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Liver physiology and pathology
- Soft tissue tumor case studies
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- Organ Transplantation Techniques and Outcomes
- Genetic and Kidney Cyst Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
King's College Hospital
2015-2025
King's College Hospital NHS Foundation Trust
2010-2024
Kobe University
2014-2024
King's College London
2012-2024
John Wiley & Sons (Germany)
2024
Kobe University Hospital
2016-2023
Pliant (United States)
2022
Ministry of Health Labour and Welfare
2020
Tokyo-Kita Medical Center
2019
American Journal Experts (United States)
2018
John H. Stone, Arezou Khosroshahi, Vikram Deshpande, K. C. Chan, J. Godfrey Heathcote, Rob Aalberse, Atsushi Azumi, Donald B. Bloch, William R. Brugge, Mollie N. Carruthers, Wah Cheuk, Lynn Cornell, Carlos Fernandez-Del Castillo, Judith A. Ferry, David Forcione, Gunter Kloppel, Daniel L. Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Yasufumi Masaki, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant Sahani, Yasuharu Sato, Thomas Smyrk, James...
Immunoglobin G (IgG) 4-related sclerosing pancreatitis and cholangitis (autoimmune pancreato-cholangitis [AIPC]) are recently recognized disease entities characterized by high serum IgG4 concentrations inflammation with numerous IgG4-positive plasma cells, although the underlining immune mechanism remains only speculative. In this study, immunopathogenesis of AIPC was examined respect to production cytokines in situ possible involvement regulatory T cells (Tregs) using fresh (5 cases)...
<h3>Background:</h3> Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it also an IgG<sub>4</sub>-related disorder. <h3>Objective:</h3> To determine the differences between disorders including MD and SS. <h3>Methods:</h3> A study was undertaken to investigate patients with registered in Japan set up provisional criteria for new clinical entity IgG<sub>4</sub>-positive multiorgan lymphoproliferative (IgG<sub>4</sub>+MOLPS). The preliminary...
IgG4-related disease (IgG4-RD) is a novel clinical entity characterized by an elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4-positive plasma cells. IgG4-RD encompasses wide variety of diseases, formerly diagnosed as Mikulicz's (MD), autoimmune pancreatitis (AIP), hypophysitis, Riedel thyroiditis, tubulointerstitial nephritis, prostatitis, retroperitoneal fibrosis, inflammatory aortic aneurysm pseudotumor. However, like crow flying on dark night, passed through...
IgG4-related disease has been identified in various organs, but whether or not there are organ-specific characteristics related to the etiologic factors is still unknown. Here, we carried out a cross-sectional study of 114 patients with disease. On basis location lesions, were classified into 5 groups: head and neck (n=23), thoracic (n=16), hepatic pancreatobiliary (n=27), retroperitoneal (n=13), systemic (n=35). All groups had similar clinicopathologic features aspects. However, some...
Autoimmune pancreatitis (AIP) is a treatable form of chronic that has been increasingly recognised over the last decade. We set out to better understand current burden AIP at several academic institutions diagnosed using International Consensus Diagnostic Criteria, and describe long-term outcomes, including organs involved, treatments, relapse frequency sequelae.23 from 10 different countries participated in this multinational analysis. A total 1064 patients meeting Criteria for type 1...
Sclerosing cholangitis (SC) is a heterogeneous disease entity. Different etiologies such as choledocholithiasis, biliary tumor, or pericholangitis can manifest SC. Hepatic inflammatory pseudotumor (IP) rarely associated with SC (sclerosing hepatic pseudotumor; SC-hepatic IP), but sclerosing pancreatitis (SP) not infrequently bile duct lesions pancreatitis-associated cholangitis; SP-SC). In this study, we compared the histologic changes of hilar and extrahepatic (7 cases), IP (5 SP-SC typical...
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), 13th (Vancouver, British Columbia, Canada, October 2015) meetings of Conference Pathology. Discussion continued online. primary goal was to introduce guidelines consensus criteria for diagnosis provide a comprehensive update all Schema recommendations....
Recently, nonalcoholic steatohepatitis (NASH) was found to be correlated with cardiovascular disease events independently of the metabolic syndrome. The aim this study investigate whether an atherogenic (Ath) diet induces pathology necessary for diagnosis human NASH and how cholesterol triglyceride alter hepatic gene expression profiles responsible oxidative stress. We investigated liver plasma lipids mice fed Ath diet. profile examined microarrays real-time polymerase chain reactions....
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop validate an international set of classification criteria IgG4-RD.An multispecialty group 86 physicians assembled by the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation...
Immunoglobulin G4-related disease (IgG4-RD) is a recently discovered systemic condition, in which various organ manifestations are linked by similar histological appearance. Our knowledge of this condition still fragmented, as most studies have examined only few dozen patients or focused on particular manifestation. This study was conducted to learn the demography and patient characteristics IgG4-RD using large cohort. A total 235 consecutive with IgG4-RD, diagnosed 8 general hospitals same...
Recently, attention has been drawn to papillary neoplasm of the pancreatobiliary systems. In pancreas, disease entity intraductal mucinous (IPMN-P) is widely recognized. contrast, pathological characteristics biliary tumors, such as papilloma(tosis) and cholangiocarcinoma, have not yet well documented. this study, we compared features post-operative prognosis among tumors (10 cases 22 cholangiocarcinoma), conventional non-papillary cholangiocarcinoma (15 cases), IPMN-P (31 cases)....
Chronic sclerosing sialadenitis (CSS) is a cryptogenic tumor-like condition of the salivary gland(s). While immune-mediated processes are suspected in its pathogenesis, and CSS occasionally reported to be associated with pancreatitis, an IgG4-related disease, exact immunopathologic remain speculative. In this study, we examined clinicopathologic findings (12 cases) comparison sialolithiasis (8 Sjögren's syndrome (13 cases), tried clarify whether disease or not. Submandibular gland(s) were...
Immunoglobulin G4 (IgG4)-related disorders can occur in the respiratory system. However, clinicopathologic characteristics have not been well clarified. In this study, we examined clinical and pathologic features of, follow-up data on, IgG4-related lung pleural lesions. The patients group consisted of 17 males 4 females with an average age 69 years (range: 42 to 76). Pulmonary lesions 16 5 were examined. Histologically, all showed diffuse lymphoplasmacytic infiltration. Irregular fibrosis...
Purpose To analyze the correlation between signal intensity in hepatobiliary phase of gadoxetic acid–enhanced magnetic resonance (MR) imaging and expression hepatocyte transporters with histopathologic features hepatocellular carcinoma (HCC). Materials Methods Institutional ethics committee approval informed consent were obtained. Forty surgically resected HCCs classified as hypointense (n = 32) or iso- hyperintense 8) on basis findings MR imaging. The following compared HCCs: time–signal...
To retrospectively analyze radiologic findings of immunoglobulin G4 (IgG4)-related lung disease as correlated with pathologic specimens.This study was approved by the institutional review board, and all patients had consented to use their medical records for purpose research. This included 13 IgG4-related (nine men four women; age range, 43-76 years). Computed tomographic (CT) were analyzed regard characteristics, shape, distribution surgically resected or biopsy specimens in seven patients....
The possible involvement of immunoglobulin G4 (IgG4) in the pathogenesis idiopathic sclerosing lesions has been suggested. In this study, a clinicopathologic analysis was performed to reveal characteristics retroperitoneal fibrosis relating IgG4. study involved 17 patients with fibrosis. Immunohistochemistry revealed numerous IgG4-positive plasma cell infiltrates 10 cases (IgG4-related), but only few positive cells 7 (non-IgG4-related). All IgG4-related were male, whereas all except 1...
Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular‐cholangiocarcinoma." These tumors, although described over 100 years ago, attracted greater attention recently because of interest in possible stem cell origin perhaps frequency clinical recognition. Currently, a lack common terminology the literature, effective treatment predictable outcome data challenging accrue. This article represents consensus...
Abstract Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer cells; CSCs). CSCs are considered pivotal target for the eradication cancer, and liver have been identified use various markers. However, little information known about expression patterns characteristics marker-positive CSCs, hampering development personalized CSC-targeted therapy. Here, we show CSC markers EpCAM CD90 independently expressed in cancer. In...