A5100765872- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Molecular Biology Techniques and Applications
- Liver physiology and pathology
- Cancer Research and Treatments
- Immune cells in cancer
- Tryptophan and brain disorders
- Circular RNAs in diseases
- RNA Research and Splicing
- Stress Responses and Cortisol
National Institutes of Health
2015-2025
National Cancer Institute
2016-2025
Center for Cancer Research
2016-2025
Tianjin Medical University Cancer Institute and Hospital
2023-2025
First People's Hospital of Chongqing
2024-2025
Shanghai Ninth People's Hospital
2025
Shanghai Jiao Tong University
2024-2025
ZheJiang Academy of Agricultural Sciences
2025
Genesis Foundation
2013-2024
Harbin Institute of Technology
2014-2024
Primary liver tumors and metastasis currently represent the leading cause of cancer-related death. Commensal bacteria are important regulators antitumor immunity, although is exposed to gut bacteria, their role in surveillance poorly understood. We found that altering commensal mice induced a liver-selective effect, with an increase hepatic CXCR6+ natural killer T (NKT) cells heightened interferon-γ production upon antigen stimulation. In vivo functional studies showed NKT mediated tumor...
Abstract Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who receive curative therapies. At present, it is challenging to identify with high risk of recurrence, which would warrant additional In this study, we sought analyze a recently developed metastasis-related gene signature for its utility predicting HCC survival, using 2 independent cohorts consisting total 386 received radical resection. Cohort 1 contained 247 predominantly HBV-positive cases...
Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, response to interferon alfa both men women with the disease.We analyzed three independent cohorts included total of 455 patients hepatocellular who had undergone radical tumor resection between 1999 2003. MicroRNA-expression profiling was performed cohort 241 identify tumor-related microRNAs determine their association survival women. In addition, validate...
MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated HCC metastasis. examined miRNA profiles 482 cancerous noncancerous specimens from radical resection 241 patients HCC. Using supervised algorithm clinically well-defined cohort 131 cases, we built unique 20-miRNA signature that...
Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack appropriate biomarkers have hampered patient prognosis treatment stratification. Recently, we identified that a hepatic stem cell marker, epithelial adhesion molecule (EpCAM), may serve as an early biomarker HCC because its expression is highly elevated in premalignant tissues subset HCC. In this study, aimed to identify novel subtypes resemble certain stages liver lineages by searching for EpCAM-coexpressed...
Chronic active hepatitis caused by infection with B virus, a DNA is major risk factor for human hepatocellular carcinoma. Since the oncogenicity of several viruses dependent on interaction their viral oncoproteins cellular tumor-suppressor gene products, we investigated between virus X protein (HBX) and wild-type p53 protein. HBX complexes inhibits its sequence-specific binding in vitro. expression also p53-mediated transcriptional activation vivo vitro association ERCC3, general...
Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape liver cancer biospecimens from 19 patients. We found varying degrees heterogeneity malignant cells within between diverse landscapes tumor microenvironment (TME). Strikingly, with higher were associated patient's worse overall survival. link hypoxia-dependent vascular endothelial growth expression TME polarization....
G 1 /S and 2 /M cell cycle checkpoints maintain genomic stability in eukaryotes response to genotoxic stress. We report here both genetic functional evidence of a Gadd45-mediated checkpoint human murine cells. Increased expression Gadd45 via microinjection an vector into primary fibroblasts arrests the cells at boundary with phenotype MPM2 immunopositivity, 4 n DNA content and, 15% cells, centrosome separation. The arrest depends on wild-type p53, because no was observed either p53-null...
MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it heterogeneous in clinical outcomes biological activities. Recently, we have identified a subset highly invasive epithelial cell adhesion molecule (EpCAM)+ HCC cells from alpha-fetoprotein (AFP)+ tumors cancer stem/progenitor features, is, abilities self-renew, differentiate, initiate...
The tumor suppressor gene product p53 plays an important role in the cellular response to DNA damage from exogenous chemical and physical mutagens. Therefore, we hypothesized that performs a similar putative endogenous mutagens, such as nitric oxide (NO). We report here exposure of human cells NO generated donor or overexpression inducible synthase (NOS2) results protein accumulation. In addition, expression wild-type (WT) variety cell lines, well murine fibroblasts, down-regulation NOS2...
Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack appropriate biomarkers have hampered patient prognosis treatment stratification. Using a gene expression profiling approach, we recently identified novel prognostic HCC subtype that resembles hepatic progenitor cells with activation stem cell markers Wnt–β-catenin signaling, based on EpCAM (epithelial adhesion molecule, marker) expression. In this study, investigated whether pathway regulates We found nuclear...
Abstract Purpose: The dismal outcome of esophageal cancer patients highlights the need for novel prognostic biomarkers, such as microRNAs (miRNA). Although recent studies have established role miRNAs in carcinoma, a comprehensive multicenter study investigating different histologic types, including squamous cell carcinoma (SCC) and adenocarcinoma with or without Barrett's, is still lacking. Experimental Design: miRNA expression was measured cancerous adjacent noncancerous tissue pairs...