A5061128412- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- interferon and immune responses
- Protein Degradation and Inhibitors
- Telomeres, Telomerase, and Senescence
- Organ Transplantation Techniques and Outcomes
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Educational Assessment and Pedagogy
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Reproductive System and Pregnancy
- Open Education and E-Learning
- Liver physiology and pathology
- Respiratory and Cough-Related Research
- Microbial Metabolism and Applications
- S100 Proteins and Annexins
- Pediatric health and respiratory diseases
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
Medizinische Hochschule Hannover
2022-2025
Helmholtz Centre for Infection Research
2011-2024
University of Tübingen
2013-2018
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced HCC are limited. Here, we observe that intestinal dysbiosis affects antitumor immune surveillance drives liver disease progression towards cancer. Dysbiotic microbiota, as seen in Nlrp6
γδT cells represent the majority of lymphocytes in several mucosal tissues where they contribute to tissue homoeostasis, microbial defence and wound repair. Here we characterise a population interleukin (IL) 17-producing γδ (γδ17) T that seed testis naive C57BL/6 mice, expand at puberty persist throughout adulthood. We show this is foetal-derived displays T-cell receptor (TCR) repertoire highly biased towards Vγ6-containing rearrangements. These γδ17 were major source IL-17 testis, whereas...
Abstract Primary liver cancer (PLC) comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) represents the third deadliest worldwide with still insufficient treatment options. We have previously found that CD4 T helper 1 (Th1) response is indispensable for protection against PLC. In present research, we aimed to test potent inducers of Th1 responses, live-attenuated Listeria monocytogenes ∆actA/∆inlB strain as preventive/therapeutic vaccine candidate in fibrosis, HCC, CCA....
Hepatocellular carcinoma (HCC) represents the third deadliest cancer worldwide with limited treatment options. Immune checkpoint inhibitors (ICIs) have revolutionized HCC therapy, but immune suppression within tumor microenvironment remains a major challenge. Therefore, in this study, we aimed to define novel ICI molecules arising on T cells during aggressive development. Using autochthonous models, performed microarray analyses followed by vivo RNA interference screen and identified several...
Mucosal barrier integrity and pathogen clearance is a complex process influenced by both Th17 Treg cells. Previously, we had described the DNA methylation profile of cells identified Zinc finger protein (Zfp)362 to be uniquely demethylated. Here, generated Zfp362
Marie Curie once said, "Nothing in life is to be feared; it only understood." Or perhaps, as we like think, "only enlightened." The ENLIGHT-TEN+ (E10+) project, short for European Network Linking Informatics and Genomics of Helper T cells Tissues embodies this spirit a Skłodowska-Curie Action (MSCA)-funded innovative training network (ITN). It offers advanced T-cell immunology big data analysis, blending scientific rigor with fearless creative exploration. Fifteen students were selected...
The sources of hepatocellular carcinoma are liver progenitor cells or hepatocytes. Interestingly, we observed differences between cell- and hepatocyte- derived carcinomas in mice. Oncogenic Nras (NrasG12V) efficiently triggers from p53-/- cells, however almost no tumor growth is observed, when NrasG12V delivered into Since aggressive develop after short latency upon delivery oncogenic p19Arf-/- hepatocytes, suggest that p19Arf mediates a p53-independent suppressive function To identify...
The tumor suppressor protein p19Arf (p14 in human) is known as an important linker between oncogenic induction and activation of p53. However, also p53 independent functions are under discussion. To identify suppressive networks hepatocellular carcinoma (HCC), we established a new approach to deliver oncogenes marker genes combination with shRNAmir induced gene knockdown into murine hepatocytes via transposable elements.