A5053997167- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Educational Assessment and Pedagogy
- vaccines and immunoinformatics approaches
- COVID-19 epidemiological studies
- Atherosclerosis and Cardiovascular Diseases
- Open Education and E-Learning
- Prenatal Screening and Diagnostics
- Influenza Virus Research Studies
- Single-cell and spatial transcriptomics
- Diabetes and associated disorders
- Spreadsheets and End-User Computing
Babraham Institute
2022-2025
The University of Melbourne
2023
Peter Doherty Institute
2023
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the serious outcomes; however, their effectiveness in people obesity incompletely understood. We studied relationship among body mass index (BMI), hospitalization mortality due to 3.6 million Scotland using Early Pandemic Evaluation Enhanced Surveillance (EAVE II) surveillance platform. found that vaccinated individuals (BMI > 40 kg/m
Skin-resident CD8+ T cells include distinct interferon-γ-producing [tissue-resident memory type 1 (TRM1)] and interleukin-17 (IL-17)-producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms establish tissue residence is unknown. In this work, we show TRM1 TRM17 navigate divergent trajectories acquire residency in the skin. depend on a T-bet-Hobit-IL-15 axis, whereas develop independently of factors. Instead, c-Maf...
Influenza infection imparts an age-related increase in mortality and morbidity. The most effective countermeasure is vaccination; however, vaccines offer modest protection older adults. To investigate how aging impacts the memory B cell response, we track hemagglutinin-specific cells by indexed flow sorting single-cell RNA sequencing (scRNA-seq) 20 healthy adults that were administered trivalent influenza vaccine. We demonstrate skewing compartment 6 weeks after vaccination, with younger...
Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding impact of age on booster third doses. Here, we show that individuals 70 years or older (median 73, range 70–75) who received two-dose schedule with AZD1222 and dose mRNA vaccine achieve significantly lower neutralizing antibody against SARS-CoV-2 spike pseudotyped virus compared those younger than 66, 54–69) at 1 month post booster. Impaired neutralization potency...
The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within air. Chronic exposure allergens other airborne antigens can result in formation lymphocyte aggregates lung, which harbor ectopic germinal centers (GCs). After allergen exposure, GCs that form lung much smaller less densely packed with B cells than lymph node GCs. Despite this, support somatic hypermutation affinity-based maturation as GCs, export memory (MBCs) directly into tissue. This...
Affinity maturation, the progressive increase in serum Ab affinity after vaccination, is an essential process that contributes to effective humoral response against vaccines and infections. Germinal centers are key for because they where B cells undergo somatic hypermutation of their Ig genes dark zone before going through positive selection light via interactions with T follicular helper dendritic cells. In aged mice, maturation has been shown be impaired immunization, but whether...
ABSTRACT Obesity is associated with an increased risk of severe Covid-19. However, the effectiveness SARS-CoV-2 vaccines in people obesity unknown. Here we studied relationship between body mass index (BMI), hospitalization and mortality due to Covid-19 amongst 3.5 million Scotland. Vaccinated (BMI>40 kg/m 2 ) were significantly more likely experience or death from Excess time since vaccination. To investigate underlying mechanisms, conducted a prospective longitudinal study immune...
Marie Curie once said, "Nothing in life is to be feared; it only understood." Or perhaps, as we like think, "only enlightened." The ENLIGHT-TEN+ (E10+) project, short for European Network Linking Informatics and Genomics of Helper T cells Tissues embodies this spirit a Skłodowska-Curie Action (MSCA)-funded innovative training network (ITN). It offers advanced T-cell immunology big data analysis, blending scientific rigor with fearless creative exploration. Fifteen students were selected...
Abstract Affinity maturation, the progressive increase in serum antibody affinity after vaccination, is an essential process that contributes to effective humoral response against vaccines and infections. Germinal centres (GCs) are key for as they where B cells undergo somatic hypermutation of their immunoglobulin genes dark zone, before going through positive selection light zone via interactions with T follicular helper dendritic cells. In aged mice, maturation has been shown be impaired,...
Age is a major risk factor for hospitalization and death after SARS-CoV-2 infection, even in vaccinees. Suboptimal responses to primary vaccination course have been reported the elderly, but there little information regarding impact of age on booster third doses. Here we show that individuals 70 or older who received two dose schedule with AZD1222 mRNA vaccine achieved significantly lower neutralizing antibody against spike pseudotyped virus compared those younger than 70. One month neither...