Emily C. Horner
A5070510070- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Adolescent and Pediatric Healthcare
- Clostridium difficile and Clostridium perfringens research
- Menopause: Health Impacts and Treatments
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Comics and Graphic Narratives
- Infection Control and Ventilation
- RNA and protein synthesis mechanisms
- S100 Proteins and Annexins
- Viral gastroenteritis research and epidemiology
- Educational Methods and Media Use
- Fatty Acid Research and Health
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Biosensors and Analytical Detection
University of Cambridge
2012-2024
Medical Research Council
2022-2024
MRC Toxicology Unit
2021-2023
University of Birmingham
2023
Extension of the interval between vaccine doses for BNT162b2 mRNA was introduced in United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed study healthcare workers. The first dose induced protection from infection circulating alpha (B.1.1.7) variant over several weeks. In substudy 589 individuals, show that induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses sustained...
Abstract In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT transfected into target cells, where they translated recombinant protein, and the biological activity or immunogenicity of encoded protein exerts an intended therapeutic effect 1,2 . Modified ribonucleotides commonly incorporated to decrease innate 3–5 , but effects on mRNA translation fidelity have...
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the serious outcomes; however, their effectiveness in people obesity incompletely understood. We studied relationship among body mass index (BMI), hospitalization mortality due to 3.6 million Scotland using Early Pandemic Evaluation Enhanced Surveillance (EAVE II) surveillance platform. found that vaccinated individuals (BMI > 40 kg/m
Both infection and vaccination, alone or in combination, generate antibody T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the maintenance of such responses-and hence protection from disease-requires careful characterization. In a large prospective study UK healthcare workers (HCWs) (Protective Immunity Cells Healthcare Workers [PITCH], within larger SARS-CoV-2 Reinfection Evaluation [SIREN] study), we previously observed that prior strongly...
Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain gold standard, but are impractical high-throughput screening. In this study, we show that expression viral proteases may be used quantitate infected cells. Our exploit cleavage specific oligopeptide linkers, leading activation cell-based optical biosensors. First, characterise...
Abstract Age-associated B cells (ABC) accumulate with age and in individuals different immunological disorders, including cancer patients treated immune checkpoint blockade those inborn errors of immunity. Here, we investigate whether ABCs from conditions are similar how they impact the longitudinal level COVID-19 vaccine response. Single-cell RNA sequencing indicates that distinct aetiologies have common transcriptional profiles can be categorised according to their expression genes, such...
Bidirectional interactions between the immune system and gut microbiota are key contributors to various physiological functions. Immune-associated diseases such as cancer autoimmunity, efficacy of immunomodulatory therapies, have been linked microbiome variation. Although COVID-19 infection has shown cause microbial dysbiosis, it remains understudied whether inflammatory response associated with vaccination also impacts microbiota. Here, we investigate temporal impact on in healthy...
Emergence from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been facilitated by rollout of effective vaccines. Successful vaccines generate high-affinity plasma blasts and long-lived protective memory B cells. Here, we show a requirement for T follicular helper (Tfh) cells germinal center reaction optimal serum antibody cell formation after ChAdOx1 nCoV-19 vaccination. We found that Tfh play an important role in expanding antigen-specific while identifying...
Abstract Both infection and vaccination, alone or in combination, generate antibody T cell responses against SARS-CoV-2. However, the maintenance of such – hence protection from disease requires careful characterisation. In a large prospective study UK healthcare workers (Protective immunity cells Healthcare (PITCH), within larger SARS-CoV-2 & reinfection evaluation (SIREN) study) we previously observed that prior impacted strongly on subsequent cellular humoral induced after long short...
ABSTRACT Obesity is associated with an increased risk of severe Covid-19. However, the effectiveness SARS-CoV-2 vaccines in people obesity unknown. Here we studied relationship between body mass index (BMI), hospitalization and mortality due to Covid-19 amongst 3.5 million Scotland. Vaccinated (BMI>40 kg/m 2 ) were significantly more likely experience or death from Excess time since vaccination. To investigate underlying mechanisms, conducted a prospective longitudinal study immune...
Abstract The bidirectional interaction between the immune system and gut microbiota is a key contributor to various host physiological functions. Immune-associated diseases such as cancer autoimmunity, well efficacy of immunomodulatory therapies, have been linked microbiome variation. While COVID-19 infection has shown cause microbial dysbiosis, it remains understudied whether inflammatory response associated with vaccination also impacts microbiota. Here, we investigate temporal impact on...
Abstract Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain gold standard, but are impractical high-throughput screening. In this study, we show that expression viral proteases may be used quantitate infected cells. Our exploit cleavage specific oligopeptide linkers, leading activation cell-based optical biosensors. First,...
Abstract Age-associated B cells (ABCs) accumulate with age, as well in individuals a range of immunological dyscrasias. These include patients cancer treated immune checkpoint blockade and inborn errors immunity. In this study, we sought to determine whether ABCs found all these conditions are similar, they enhance or detract from the response COVID-19 vaccination. We use single cell RNA sequencing show that arising distinct aetiologies have common transcriptional profiles may be subdivided...