Ahmed Alhussni
A5008740496- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Muscle Physiology and Disorders
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Cardiomyopathy and Myosin Studies
- vaccines and immunoinformatics approaches
University of Oxford
2019-2022
Oxford University Hospitals NHS Trust
2021
Extension of the interval between vaccine doses for BNT162b2 mRNA was introduced in United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed study healthcare workers. The first dose induced protection from infection circulating alpha (B.1.1.7) variant over several weeks. In substudy 589 individuals, show that induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses sustained...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody measurements can be used to estimate the proportion of a population exposed or infected and may informative about risk future infection. Previous estimates duration responses vary. Methods We present 6 months data from longitudinal seroprevalence study 3276 UK healthcare workers (HCWs). Serial SARS-CoV-2 anti-nucleocapsid anti-spike IgG were obtained. Interval censored survival...
The extent to which immune responses natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization vaccines protect against variants of concern (VOC) is increasing importance. Accordingly, here we analyse antibodies T cells a recently vaccinated, UK cohort, alongside those recovering from in early 2020. We show that neutralization the VOC compared reference isolate original circulating lineage, B, reduced: more profoundly B.1.351 than for B.1.1.7, or...
Abstract The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study UK healthcare workers prior vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show highly variable range responses, some which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B memory ELISpot) stable. use...
Recessive ryanodine receptor 1 (RYR1) mutations cause congenital myopathies including multiminicore disease (MmD), fiber-type disproportion and centronuclear myopathy. We created a mouse model knocked-in for the Q1970fsX16+A4329D RYR1 mutations, which are isogenic with those identified in severely affected child MmD. During first 20 weeks after birth body weight spontaneous running distance of mutant mice were 20% 50% lower compared to wild-type littermates. Skeletal muscles from contained...