Nayia Petousi
A5087311719- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- COVID-19 and Mental Health
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Hemoglobinopathies and Related Disorders
- COVID-19 and healthcare impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Iron Metabolism and Disorders
- Frailty in Older Adults
- Medical Imaging and Pathology Studies
University of Oxford
2016-2025
Oxford BioMedica (United Kingdom)
2019-2025
Oxford University Hospitals NHS Trust
2016-2025
Imperial College London
2022-2024
Oxford Biomedical Research
2016-2024
John Radcliffe Hospital
2023
NIHR Leicester Biomedical Research Centre
2023
University of Leicester
2023
University Hospitals of Leicester NHS Trust
2023
University of Manchester
2023
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
The extent to which immune responses natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization vaccines protect against variants of concern (VOC) is increasing importance. Accordingly, here we analyse antibodies T cells a recently vaccinated, UK cohort, alongside those recovering from in early 2020. We show that neutralization the VOC compared reference isolate original circulating lineage, B, reduced: more profoundly B.1.351 than for B.1.1.7, or...
The longitudinal trajectories of cardiopulmonary abnormalities and symptoms following infection with coronavirus disease (COVID-19) are unclear. We sought to describe their natural history in previously hospitalised patients, compare this controls, assess the relationship between impairment at 6 months post-COVID-19.
Tibetan natives have lived on the plateau (altitude ∼4,000 m) for at least 25,000 years, and as such they are adapted to life reproduction in a hypoxic environment. Recent studies identified two genetic loci, EGLN1 EPAS1, that undergone natural selection Tibetans, further demonstrated an association of EGLN1/ EPAS1 genotype with hemoglobin concentration. Both genes encode major components hypoxia-inducible factor (HIF) transcriptional pathway, which coordinates organism's response hypoxia....
The indigenous people of the Tibetan Plateau have been subject much recent interest because their unique genetic adaptations to high altitude. Recent studies demonstrated that EPAS1 haplotype is involved in altitude-adaptation and originated an archaic Denisovan-related population. We sequenced whole-genomes 27 Tibetans conducted analyses infer a detailed history demography natural selection this detected evidence population structure between ancestral Han subpopulations as early 44 58...
Erythrocytosis is a rare disorder characterized by increased red cell mass and elevated hemoglobin concentration hematocrit. Several genetic variants have been identified as causes for erythrocytosis in genes belonging to different pathways including oxygen sensing, erythropoiesis transport. However, despite clinical investigation screening these mutations, the cause of disease cannot be found considerable number patients, who are classified having idiopathic erythrocytosis. In this study,...
Abstract Background The medium-term effects of Coronavirus disease (COVID-19) on multiple organ health, exercise capacity, cognition, quality life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge 30 comorbidity-matched controls were prospectively enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments. Findings...
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed assess whether successful awake COVID-19, respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) a high-dependency unit (HDU), associated improved outcomes. HDU care included by physiotherapists....
Abstract The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study UK healthcare workers prior vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show highly variable range responses, some which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B memory ELISpot) stable. use...
Rationale: Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause daytime increases blood pressure (BP).Objectives: To establish role of hypoxia increased morning BP patients OSA.Methods: Randomized, double-blinded, crossover trial assessing effects supplemental oxygen versus air (sham) on BP, after continuous positive airway (CPAP) withdrawal moderate to severe OSA. The primary...
Biologic therapies targeting components of the type-2 inflammatory response seen in many patients with obstructive airways disease have had a dramatic impact clinic. In severe asthma clinic, extraordinary outcomes are being achieved1 and days when clinicians' job was mainly about overseeing an orderly decline (much it due to oral corticosteroid-related morbidity) been confined history books. 2023, is projected that sales will top $10 billion, accounting for over 30% total worldwide drug...
We set out to describe the fine-scale population structure across Eastern region of Nepal. To date there is relatively little known about genetic Sherpa residing in Nepal and their relationship with Nepalese. assembled dense genotype data from a total 1245 individuals representing variety different populations resident greater Himalayan including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan Kirghizstan. performed analysis principal components, admixture homozygosity.We...
Introduction/Aim Lung inhomogeneity measures obtained using computed cardiopulmonography (CCP) are sensitive to small-airways disease. Here, we assessed changes in lung patients with type-2 high asthma treated biological therapy and explored the relationship between conventional disease markers. Methods This was an observational study of 91 severe recruited from a tertiary clinic, whom 67 subsequently started anti-IL5 or anti-IL5R biologics. Patients were evaluated at baseline and, 54 those...
The number of people with multiple long-term conditions (MLTC) is increasing. People MLTC experience fragmentation care due to single-disease-orientated healthcare organisation and have increased morbidity mortality. We developed an innovative clinic model whereby are assessed by a team specialists together in one appointment form consensus management plan real time. report the outcomes patient clinician feedback. A multispecialty was established assess adults referred from community or...
Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, treatment response in OSA. Participants (n = 1391) the Stanford Technology Analytics Genomics Sleep had blood collected completed overnight polysomnography for scoring apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was...