A5053583791- Pleural and Pulmonary Diseases
- Ultrasound in Clinical Applications
- Lung Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Pneumothorax, Barotrauma, Emphysema
- Occupational and environmental lung diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Amoebic Infections and Treatments
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pericarditis and Cardiac Tamponade
- Radiology practices and education
- Gut microbiota and health
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Autopsy Techniques and Outcomes
- Advanced Electron Microscopy Techniques and Applications
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
Oxford University Hospitals NHS Trust
2016-2025
University of Oxford
2016-2025
Oxford BioMedica (United Kingdom)
2015-2025
Churchill Hospital
2015-2024
Oxford Centre for Diabetes, Endocrinology and Metabolism
2014-2024
Respiratory Clinical Trials
2023
Government of the United Kingdom
2023
John Radcliffe Hospital
2022
Nuffield Health
2021
Norfolk and Norwich University Hospitals NHS Foundation Trust
2019
<h3>Importance</h3> For treatment of malignant pleural effusion, nonsteroidal anti-inflammatory drugs (NSAIDs) are avoided because they may reduce pleurodesis efficacy. Smaller chest tubes be less painful than larger tubes, but efficacy in has not been proven. <h3>Objective</h3> To assess the effect tube size and analgesia (NSAIDs vs opiates) on pain clinical related to patients with effusion. <h3>Design, Setting, Participants</h3> A 2×2 factorial phase 3 randomized trial among 320 requiring...
### Spontaneous pneumothorax #### Acute management for spontaneous ##### Recommendations Good practice points Optimal after the resolution of a first episode and ongoing air leak point
Background The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendations of SP. Methods multidisciplinary Task Force addressed 12 key questions on pneumothorax, using ERS methodology development. Systematic searches were performed in MEDLINE Embase. Evidence was synthesised by conducting meta-analyses, if possible, or...
<h3>Importance</h3> Spontaneous pneumothorax is a common disease known to have an unusual epidemiological profile, but there are limited contemporary population-based data. <h3>Objective</h3> To estimate the incidence of hospital admissions for spontaneous pneumothorax, its recurrence and trends over time using large, longstanding hospitalization data sets in England. <h3>Design, Setting, Participants</h3> A study was conducted English national set regional set, each spanning 1968 2016,...
Background The minimal important difference (MID) is essential for interpreting the results of randomised controlled trials (RCTs). Despite a number RCTs in patients with malignant pleural effusions (MPEs) which use visual analogue scale dyspnea (VASD) as an outcome measure, MID has not been established. Methods Patients suspected MPE undergoing procedure recorded their baseline VASD and post-procedure (24 hours after drainage), parallel assessed breathlessness on 7 point Likert scale....
The definitive diagnosis of pleural malignancy depends upon histological confirmation by biopsy. CT is reported to have a high sensitivity and specificity for the malignant disease, part routine diagnostic workup these patients. aim this study was assess in detecting prior histology obtained via thoracoscopy large cohort patients with suspected disease. Retrospective review thoracoscopies between January 2008 2013 at two UK tertiary referral centres: Oxford Preston. results were compared...
BackgroundPrimary spontaneous pneumothorax occurs in otherwise healthy young patients. Optimal management is not defined and often results prolonged hospitalisation. Data on efficacy of ambulatory options are poor. We aimed to describe the duration hospitalisation safety compared with standard care.MethodsIn this open-label, randomised controlled trial, adults (aged 16–55 years) symptomatic primary were recruited from 24 UK hospitals during a period 3 years. Patients randomly assigned (1:1)...
Background Over 30% of adult patients with pleural infection either die and/or require surgery. There is no robust means predicting at baseline presentation which will suffer a poor clinical outcome. A validated risk prediction score would allow early identification high-risk patients, potentially directing more aggressive treatment thereafter. Objectives To prospectively assess previously described (the RAPID (Renal (urea), Age, fluid Purulence, Infection source, Dietary (albumin)) score)...
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed assess whether successful awake COVID-19, respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) a high-dependency unit (HDU), associated improved outcomes. HDU care included by physiotherapists....
Background There is an emerging understanding that coronavirus disease 2019 (COVID-19) associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its among patients hospitalised COVID-19 in the UK and describe factors outcome. Methods A structured survey PTM was conducted from September 2020 February 2021. UK-wide participation solicited via respiratory research networks. Identified had severe acute syndrome 2 (SARS-CoV-2) infection radiologically proven PTM. The...
Rationale: Patients with malignant pleural effusion experience breathlessness, which is treated by drainage and pleurodesis. Incomplete results in residual dyspnea pleurodesis failure. Intrapleural fibrinolytics lyse septations within fluid, improving drainage.Objectives: To assess the effects of intrapleural urokinase on success patients nondraining effusion.Methods: We conducted a prospective, double-blind, randomized trial. were randomly allocated 1:1 ratio to (100,000 IU, three doses,...
Artificial intelligence (AI)-assisted image interpretation is a fast-developing area of clinical innovation. Most research to date has focused on the performance AI-assisted algorithms in comparison with that radiologists rather than evaluating algorithms' impact clinicians who often undertake initial routine practice. This study assessed diagnostic frontline acute care for detection pneumothoraces (PTX).
Abstract OBJECTIVES The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendations of SP. METHODS multidisciplinary Task Force addressed 12 key questions on pneumothorax, using ERS methodology development. Systematic searches were performed in MEDLINE Embase. Evidence was synthesised by conducting meta-analyses, if possible, or...