A5018887395- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Sleep and Wakefulness Research
- Medical Imaging and Pathology Studies
- Airway Management and Intubation Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Case Reports on Hematomas
- Sleep and related disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Soft tissue tumor case studies
- Dysphagia Assessment and Management
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Sleep and Work-Related Fatigue
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Lung Cancer Diagnosis and Treatment
- High Altitude and Hypoxia
Oxford BioMedica (United Kingdom)
2015-2024
University of Oxford
2015-2024
National Institute for Health Research
2016-2022
Oxford University Hospitals NHS Trust
2013-2022
Churchill Hospital
2010-2021
Leeds Teaching Hospitals NHS Trust
2021
Oxford Biomedical Research
2013-2019
Mie University Hospital
2019
Mie University
2019
Tokyo Institute of Technology
2019
BackgroundThe SF-36 is a generic health status measure which has gained popularity as of outcome in wide variety patient groups and social surveys. However, there need for even shorter measures, reduce respondent burden. The developers the have consequently suggested that 12-item sub-set items may accurately reproduce two summary component scores can be derived from [the Physical Component Summary Score (PCS) Mental Health (MCS)]. In this paper, we adopt scoring algorithms UK SF-12 to...
Parents of 996 children aged 4-5 years identified consecutively from the Oxford health visitor register were asked to complete a questionnaire about breathing disorders during sleep. A total 782 (78.5%) was returned. Ninety five (12.1%) reported snore on most nights. Habitual snoring significantly associated with daytime sleepiness, restless sleep, and hyperactivity. The responses used select two subgroups, one at high risk sleep disorder control group. These (132 in total) monitored home...
One thousand and one men, aged 35-65 years, were identified from the age-sex register of group general practice. Over four years 900 men visited at home asked questions about symptoms potentially related to sleep apnoea snoring. Height, weight, neck circumference, resting arterial oxygen saturation (SaO2), spirometric values also determined. All night oximetry was then performed tracing analysed for number dips in SaO2 more than 4%. Subjects with five 4% or per hour invited laboratory...
<h3>Importance</h3> Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there few treatments to prevent hospital readmission death. <h3>Objective</h3> To investigate the effect home NIV plus oxygen on time or death in patients with persistent hypercapnia an COPD exacerbation. <h3>Design, Setting, Participants</h3> A randomized clinical trial (Paco<sub>2</sub>>53 mm Hg) 2 weeks 4 resolution respiratory...
BACKGROUND: Neck circumference has been suggested to be more predictive of obstructive sleep apnoea than general obesity, but the statistical validity this conclusion questioned. Combining neck with other signs and symptoms may allow clinical diagnosis or exclusion made reasonable confidence. This study examines these issues. METHODS: One hundred fifty patients referred a clinic for investigation related breathing disorders completed questionnaire covering daytime sleepiness, snoring,...
<h3>Background:</h3> The effects of continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) on insulin resistance are not clear. Trials have found conflicting results and no appropriate control groups been used. <h3>Methods:</h3> Forty-two men with known type 2 diabetes newly diagnosed OSA (>10 dips/h in oxygen saturation >4%) were randomised to receive therapeutic (n = 20) or placebo CPAP 22) 3 months. Baseline tests performed repeated after study was double...
A study was undertaken to establish the prevalence of obstructive sleep apnoea (OSA) in men with type 2 diabetes.Men diabetes from local hospital and selected primary care practitioner databases received questionnaires about snoring, apnoeas, daytime sleepiness based on Berlin questionnaire. Selected respondents had overnight oximetry whether they OSA. Comparisons were made those a previous general population study. HbA1c results collected.1682 sent questionnaires, 56% whom replied. 57%...
Rationale: To establish a new approach to investigate the physiological effects of obstructive sleep apnea (OSA), and evaluate novel treatments, during period continuous positive airway pressure (CPAP) withdrawal.Objectives: determine CPAP withdrawal.Methods: Forty-one patients with OSA receiving were randomized either withdrawal (subtherapeutic CPAP), or continued CPAP, for 2 weeks. Polysomnography, sleepiness, psychomotor performance, endothelial function, blood (BP), heart rate (HR),...
Continuous positive airway pressure (CPAP) for symptomatic obstructive sleep apnoea (OSA) improves sleepiness and reduces vascular risk, but such treatment the more prevalent, minimally disease is contentious.This multicentre, randomised controlled, parallel, hospital-based trial across UK Canada, recruited 391 patients with confirmed OSA (oxygen desaturation index >7.5/h) insufficient symptoms to warrant CPAP therapy. Patients were 6 months of auto-adjusting therapy, or standard care....
BackgroundThe therapeutic and economic benefits of continuous positive airway pressure (CPAP) for moderate to severe obstructive sleep apnoea (OSA) syndrome have been established in middle-aged people; however, the older people are unknown. This trial was designed address this evidence gap.MethodsThis 12-month, multicentre, randomised enrolled patients across 14 National Health Service centres UK. Consecutive aged 65 years or with newly diagnosed OSA were eligible join trial. Patients...
Heart failure is associated with Cheyne–Stokes breathing, which fragments patients' sleep. Correction of respiratory disturbance may reduce sleep fragmentation and excessive daytime sleepiness. This randomized prospective parallel trial assesses whether nocturnal-assist servoventilation improves sleepiness compared the control. A total 30 subjects (29 male) breathing (mean apnea–hypopnea index 19.8 [SD 2.6] stable symptomatic chronic heart (New York Association Class II–IV) were treated 1...
During obstructive sleep apnea, transient arousal at the resumption of breathing is coincident with a substantial rise in blood pressure. To assess hemodynamic effect alone, 149 stimuli were administered to five normal subjects. Two electroencephalograms (EEG), an electrooculogram, submental electromyogram (EMG), and beat-to-beat pressure (Finapres, Ohmeda) recorded all Stimulus length was varied produce range cortical EEG arousals that graded as follows: 0, no increase high-frequency or...
During physical examination of patients with suspected obstructive sleep apnea (OSA), a comment is frequently made that they appear to have short and fat neck. To confirm this subjective impression by objective measurements, we studied group 123 referred us because snoring OSA, all whom had nocturnal polysomnography measurements external internal neck circumference. The circumference was measured at the level superior border cricothyroid cartilage. Internal circumferences were calculated...
In 1989-90 a survey was carried out of the prevalence snoring and related symptoms in 782 4 to 5 year old children. Two years later, 1992, same group children studied gather information on natural history behaviour problems. A total 507/782 (64.8%) completed questionnaires were received. Comparison responses with showed that those who did not reply questionnaire no different from respondents terms snoring, daytime sleepiness, hyperactivity, restless sleep. The overall habitual change between...
There are very few data on objectively assessed long-term compliance with continuous positive airway pressure (CPAP). No single factor has been consistently identified as predictive of continued CPAP use.Adherence to and associations objective use were examined in 639 3900 patients whom treatment was started between 1994 2005. Kaplan-Meier survival analyses used estimate the proportion still CPAP. Cox regression models explore effects covariates CPAP.The median (IQR) follow-up time after...
Daytime sleepiness is an important symptom of obstructive sleep apnoea syndrome (OSAS). The standard tests for its objective quantification use EEG recordings, and are time consuming expensive, which makes them difficult to large studies. This study assesses the ability a simple test sustained ‘wakefulness’ discriminate excessive somnolence severe symptomatic from normality, compares results traditional based Maintenance Wakefulness Test (MWT). Ten subjects (7 M 3F) with (>4% SaO 2 dip...
Overnight tape recordings of breathing movements, airflow, and arterial oxygen saturation from six infants aged 3 weeks to 7 months, who had cyanotic episodes associated with pertussis, were compared 12 age matched healthy controls. In all patients clinically apparent apnoeic the rapid onset progression central cyanosis. When overnight compared, pertussis a greater frequency pauses (particularly those than or equal 12.0 seconds duration) hypoxaemia (oxygen less 80% for 0.5 seconds) pauses....
Treatment of obstructive sleep apnoea (OSA) with nasal continuous positive airway pressure (NCPAP) has become a standard treatment since its introduction in 1981. Following such the apnoeas disappear, quality improves as apparently do daytime symptoms sleepiness. Sleepiness is an unusual symptom and impact on conventional indices life rarely been measured. To allow comparison NCPAP therapy treatments for other conditions, measurements before after using techniques are required. It not clear...
Sleep fragmentation and respiratory disturbance measures are used in the assessment of obstructive sleep apnea (OSA) but have proved to be disappointingly poor correlates daytime sleepiness. This study investigates ability electroencephalograph (EEG) non-EEG indices predict both presenting sleepiness improvement with subsequent nasal continuous positive airway pressure (nCPAP) therapy (nCPAP responsive sleepiness). Forty-one patients (36 men, 5 women), ranging from nonsnorers severe OSA ( >...