A5023411224- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Pharmaceutical Economics and Policy
- Healthcare Policy and Management
- Healthcare cost, quality, practices
- Intergenerational Family Dynamics and Caregiving
- Lipoproteins and Cardiovascular Health
- Global Health Care Issues
- Pharmaceutical studies and practices
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Healthcare innovation and challenges
- Health Policy Implementation Science
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Gastroesophageal reflux and treatments
- Radiation Dose and Imaging
- Hepatitis C virus research
- Advanced Causal Inference Techniques
- Allergic Rhinitis and Sensitization
- Neonatal and Maternal Infections
- Healthcare Quality and Management
- Wildlife Conservation and Criminology Analyses
- Economic and Environmental Valuation
- Cardiac Imaging and Diagnostics
Astellas Pharma (United Kingdom)
2025
University of York
2015-2024
Centro Hospitalar de Vila Nova de Gaia
2024
Griffith University
2023
Universidade do Porto
2014-2022
Erasmus University Rotterdam
2022
Universidade Lusófona
2017
University of Sheffield
2016
Missing data are a frequent problem in cost-effectiveness analysis (CEA) within randomised controlled trial. Inappropriate methods to handle missing can lead misleading results and ultimately affect the decision of whether an intervention is good value for money. This article provides practical guidance on how within-trial CEAs following principled approach: (i) should be based plausible assumption mechanism, i.e. probability that independent or dependent observed and/or unobserved values;...
Objectives To provide national estimates of the number and clinical economic burden medication errors in National Health Service (NHS) England. Methods We used UK-based prevalence (in prescribing, dispensing, administration monitoring) primary care, secondary care home settings, associated healthcare resource use, to estimate annual NHS. Burden (healthcare use deaths) was estimated from harm with avoidable adverse drug events (ADEs). Results that 237 million occur at some point process...
BackgroundThe therapeutic and economic benefits of continuous positive airway pressure (CPAP) for moderate to severe obstructive sleep apnoea (OSA) syndrome have been established in middle-aged people; however, the older people are unknown. This trial was designed address this evidence gap.MethodsThis 12-month, multicentre, randomised enrolled patients across 14 National Health Service centres UK. Consecutive aged 65 years or with newly diagnosed OSA were eligible join trial. Patients...
The current recommendation of using transrectal ultrasound-guided biopsy (TRUSB) to diagnose prostate cancer misses clinically significant (CS) cancers. More sensitive biopsies (eg, template mapping [TPMB]) are too resource intensive for routine use, and there is little evidence on multiparametric magnetic resonance imaging (MPMRI).To identify the most effective cost-effective way these tests detect CS cancer.Cost-effectiveness modelling health outcomes costs men referred secondary care with...
Cost-effectiveness analyses (CEA) of randomised controlled trials are a key source information for health care decision makers. Missing data are, however, common issue that can seriously undermine their validity. A major concern is the chance being missing may be directly linked to unobserved value itself [missing not at random (MNAR)]. For example, patients with poorer less likely complete quality-of-life questionnaires. However, extent which this occurs cannot ascertained from hand....
Men with suspected prostate cancer usually undergo transrectal ultrasound (TRUS)-guided biopsy. TRUS-guided biopsy can cause side effects and has relatively poor diagnostic accuracy. Multiparametric magnetic resonance imaging (mpMRI) used as a triage test might allow men to avoid unnecessary improve To (1) assess the ability of mpMRI identify who safely biopsy, (2) mpMRI-based pathway rate detection clinically significant (CS) compared (3) estimate cost-effectiveness pathway. A validating...
Despite promising evidence that laparoscopic fundoplication provides better short-term relief of gastro-oesophageal reflux disease (GORD) than continued medical management, uncertainty remains about whether benefits are sustained and outweigh risks.To evaluate the long-term clinical effectiveness, cost-effectiveness safety surgery among people with GORD requiring medication suitable for both surgical management.Five-year follow-up a randomised trial (with parallel non-randomised preference...
Background The therapeutic and economic benefits of continuous positive airway pressure (CPAP) for the treatment obstructive sleep apnoea syndrome (OSAS) have been established in middle-aged people. In older people there is a lack evidence. Objective To determine clinical efficacy CPAP with OSAS to establish its cost-effectiveness. Design A randomised, parallel, investigator-blinded multicentre trial within-trial model-based cost-effectiveness analysis. Methods Two hundred seventy-eight...
Abstract Background Laparoscopic fundoplication surgery has been shown to be a cost-effective alternative continued medical management over 1 year for patients with gastro-oesophageal reflux disease (GORD). The longer-term cost-effectiveness is, however, uncertain. This study evaluated the long-term health benefits, costs and of laparoscopic compared in GORD. Methods Individual patient data were used from 5-year follow-up REFLUX trial, large multicentre, pragmatic, randomized trial which 357...
Abstract Health economic evaluations are comparative analyses of alternative courses action in terms their costs and consequences. The Consolidated Economic Evaluation Reporting Standards (CHEERS) statement, published 2013, was created to ensure health identifiable, interpretable, useful for decision making. It intended as guidance help authors report accurately which interventions were being compared what context, how the evaluation undertaken, findings were, other details that may aid...
Background Reablement is an intensive, time-limited intervention for people at risk of needing social care or increased intensity care. Differing from home care, it seeks to restore functioning and self-care skills. In England, a core element intermediate The existing evidence base limited. Objectives To describe reablement services in England develop service model typology; conduct mixed-methods comparative evaluation models investigating outcomes, factors that have impact on costs...
BackgroundTimely implementation of recommended interventions can provide health benefits to patients and cost savings the service provider. Effective approaches increase guidance are needed. Since investment in activities that improve competes for funding against other generating interventions, it should be assessed term its costs benefits.ObjectiveIn 2010, National Institute Health Care Excellence released a clinical guideline recommending natriuretic peptide (NP) testing with suspected...
PURPOSE To compare demographics, clinical characteristics, health care resource utilization (HCRU), treatment duration, and overall survival (OS) with enzalutamide (ENZA) or abiraterone acetate (AA) in patients metastatic castration-resistant prostate cancer (mCRPC) England. MATERIALS AND METHODS This retrospective study analyzed data from the Cancer Analysis System database on receiving ENZA AA (January 2014-March 2020) for chemotherapy-naïve mCRPC (mCRPC was only funded indication ENZA/AA...
Cost-effective interventions are often implemented slowly and suboptimally in clinical practice. In such situations, a range of implementation activities may be considered to increase uptake. A framework is proposed use cost-effectiveness analysis inform decisions on how best invest activities. This addresses 2 key issues: 1) account for changes utilization the future absence activities; 2) prioritize efforts between subgroups. case study demonstrates framework’s application: novel oral...
Reablement – or restorative care is a central feature of many western governments' approaches to supporting and enabling older people stay in their own homes minimise demand for social care. Existing evidence supports this approach although further research required strengthen the certainty conclusions being drawn. In countries where reablement has been rolled out nationally, an additional priority develop base on models delivery emerging. This paper reports prospective cohort study...
Abstract Purpose We estimated the cost-effectiveness of 4 radiotherapy modalities to treat early breast cancer in UK. In a subgroup patients eligible for all modalities, we compared whole-breast (WB) and partial (PB) delivered either 15 (WB15F, PB15F) or 5 fractions (WB5F, PB5F). ineligible PB radiotherapy, WB15F WB5F. Methods developed Markov cohort model simulate lifetime healthcare costs quality-adjusted life years (QALYs) each modality. This was informed by clinical analysis two...
Familial hypercholesterolemia (FH) is a monogenic disorder that causes high levels of low-density lipoprotein (LDL) cholesterol. Cascade testing, where relatives known individuals with FH ('index') are genetically tested, effective and cost-effective, but implementation in the UK varies. This study aims to provide evidence on current cascade yields identify common obstacles services face individual- service-level predictors success. Electronic health records from 875 index families 5,958...
Reablement is a time-limited intervention that aims to support people regain independence and enable them resume their daily activities after they return home from an in-patient care setting, or maintain remain at home. There some evidence reablement can enhance has the potential contain costs. However, services are funded provided in different ways by organisations, there limited research about effectiveness of service models. This study will evaluate cost-effectiveness models users'...