A5091023678- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- BRCA gene mutations in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Primary Care and Health Outcomes
- Global Cancer Incidence and Screening
- Genomics and Rare Diseases
- Pharmaceutical Economics and Policy
- Chronic Disease Management Strategies
- Genetic Associations and Epidemiology
- Prenatal Screening and Diagnostics
- Ethics in Clinical Research
- Health Promotion and Cardiovascular Prevention
- Acute Myocardial Infarction Research
- Cancer, Lipids, and Metabolism
- Acute Ischemic Stroke Management
- Diabetes Management and Education
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Cystic Fibrosis Research Advances
- Health and Medical Research Impacts
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Obesity, Physical Activity, Diet
- Clinical practice guidelines implementation
University of Nottingham
2016-2025
Shaikh Zayed Postgraduate Medical Institute
2024
Qatar Airways (Qatar)
2024
Nottingham Biomedical Research Centre
2017-2019
University of Oxford
2017
University of Birmingham
2017
Shipley Hospital
2017
Health Education England
2017
Primary Health Care
2009-2014
King Faisal Specialist Hospital & Research Centre
2009-2013
Current approaches to predict cardiovascular risk fail identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. Machine-learning offers opportunity improve accuracy by exploiting complex interactions between factors. We assessed whether machine-learning can prediction.
The presence of additional chronic conditions has a significant impact on the treatment and management type 2 diabetes (T2DM). Little is known about patterns comorbidities in this population. aims study are to quantify comorbidity people with T2DM, estimate prevalence six 2027 identify clusters similar conditions. We used Clinical Practice Research Datalink (CPRD) linked Index Multiple Deprivation (IMD) data patients diagnosed T2DM between 2007 2017. 102,394 met inclusion criteria....
Purpose: To evaluate the use of self-reported family medical history as a potential screening tool to identify people at-risk for diabetes.Methods: The HealthStyles 2004 mail survey comprises 4345 US adults who completed questionnaire ascertain personal and diabetes, perceived risk practice risk-reducing behaviors. Using number type affected relatives, respondents were ranked into three familial levels. Adjusted odds ratios (AORs) obtained associations between prevalent disease, Validity was...
Background Prognostic modelling using standard methods is well-established, particularly for predicting risk of single diseases. Machine-learning may offer potential to explore outcomes even greater complexity, such as premature death. This study aimed develop novel prediction algorithms machine-learning, in addition survival modelling, predict all-cause mortality. Methods A prospective population cohort 502,628 participants aged 40–69 years were recruited the UK Biobank from 2006–2010 and...
Objective To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk cardiovascular disease (CVD). Methods Prospective cohort study 165 411 primary care patients, from the UK Clinical Practice Research Datalink, who were free CVD before statin initiation, had at least one pre-treatment LDL-C within 12 months before, post-treatment 24 after, initiation. Based on current national guidelines, <40% reduction baseline was classified...
Abstract Summary Using the UK Clinical Practice Research Datalink, our cohort study matched 237,297 individuals with hearing loss (HL) to 829,431 without HL. The found an 8–10% higher risk of major osteoporotic fracture in HL compared those without. Additionally, within cohort, we identified factors for potential inclusion models. Purpose Assess association between and (MOF; spine, wrist/forearm, shoulder/proximal humerus, hip) aged ≥ 60 years, MOF Methods From years diagnosed (READ/ICD-10...
Given the limited specialist resources available to cope with rising demand for genetic services, it has been proposed that at least some of these services are provided by primary care in future.We aimed explore GPs' attitudes towards new developments genetics, establish role they envisage and clearly define education, information training needed support them this role.We carried out a qualitative study GPs using four focus groups (26 GPs) 15 individual semi-structured interviews.GPs...
Background: Evidence of the value systematically collecting family history in primary care is limited. Objective: To evaluate feasibility coronary heart disease and effect incorporating these data into cardiovascular risk assessment. Design: Pragmatic, matched-pair, cluster randomized, controlled trial. (International Standardized Randomized Controlled Trial Number Register: ISRCTN 17943542). Setting: 24 practices United Kingdom. Participants: 748 persons aged 30 to 65 years with no...
A family history, reflecting genetic susceptibility as well shared environmental and behavioral factors, is an important risk factor for common chronic multifactorial diseases such cardiovascular diseases, type 2 diabetes many cancers. The purpose of the present paper to discuss evidence use history a tool primary prevention in particular tailored interventions aimed at promoting healthy lifestyles. following questions are addressed: (1) What value information determinant personal disease...
Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant disorder. The vast majority of affected individuals remain undiagnosed, resulting in lost opportunities for preventing premature heart disease. Better use routine primary care data offers an opportunity to enhance detection. We sought develop new predictive algorithm improving identification who could be prioritised further clinical assessment using established diagnostic criteria.Data were analysed 2,975,281...
Aspartate aminotransferase to alanine (AST/ALT) ratio, reflecting liver disease severity, has been associated with increased risk of cardiovascular (CVD). The aim this study was evaluate whether the AST/ALT ratio improves established prediction tools in a primary care population.
Ethnic disparities in use of cancer genetics services raise concerns about equitable opportunity to benefit from familial risk assessment, improved survival and quality life. This paper considers available research explore what may hinder or facilitate minority ethnic access services. We sought inform service development for people South Asian, African Irish origin at breast, ovarian, colorectal prostate cancers the UK. Relevant studies UK, North America Australasia were identified six...
Data about variations in stroke incidence and subsequent major adverse outcomes are essential to inform secondary prevention prioritizing resources those at the greatest risk of end points. We aimed describe age, sex, socioeconomic differences rates first nonfatal outcomes.The cohort study used linked Clinical Practice Research Datalink Hospital Episode Statistics data from United Kingdom. The rate (IR) ratio (composite cardiovascular events, recurrent stroke, disease-related, all-cause...
Abstract Background In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce better balance benefits and harms. The main benefit is offer NICE-approved more frequent screening and/ or chemoprevention for women who are at increased risk, but unaware this. We have developed BC-Predict, to be offered when invited NHSBSP which collects information on risk factors (self-reported family history hormone-related via questionnaire; mammographic...
Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on heart failure, CVD and mortality has not been quantified.This population-based cohort study used routine UK primary care electronic health data linked to secondary death-registry records. We identified adults who were obese, free from had repeated BMI measures. Using group-based trajectory modelling, we examined...