A5016347038- Bone health and osteoporosis research
- Health Systems, Economic Evaluations, Quality of Life
- Hip and Femur Fractures
- Bone health and treatments
- Lipoproteins and Cardiovascular Health
- Antibiotic Use and Resistance
- Rheumatoid Arthritis Research and Therapies
- Patient Satisfaction in Healthcare
- Bone and Joint Diseases
- Chronic Disease Management Strategies
- Primary Care and Health Outcomes
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Health Promotion and Cardiovascular Prevention
- Advanced Causal Inference Techniques
- Healthcare Systems and Technology
- Statistical Methods in Clinical Trials
- Inflammatory mediators and NSAID effects
- Pharmacovigilance and Adverse Drug Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adrenal Hormones and Disorders
- Clinical practice guidelines implementation
- Bone Metabolism and Diseases
- Pneumonia and Respiratory Infections
- Orthopaedic implants and arthroplasty
University of Manchester
2016-2025
Health Data Research UK
2010-2025
Manchester Academic Health Science Centre
2016-2025
National Institute for Health Research
2025
Utrecht University
2014-2023
Farr Institute
2014-2023
Pharmo Institute
2012-2022
Environmental Research Institute
2022
Turing Institute
2019-2020
British Library
2019-2020
The Clinical Practice Research Datalink (CPRD) is an ongoing primary care database of anonymised medical records from general practitioners, with coverage over 11.3 million patients 674 practices in the UK.With 4.4 active (alive, currently registered) meeting quality criteria, approximately 6.9% UK population are included and broadly representative terms age, sex ethnicity.General practitioners gatekeepers specialist referrals UK.The CPRD therefore a rich source health data for research,...
Abstract Treatment with systemic corticosteroids is known to increase the risk of fractures but little fracture risks associated inhaled corticosteroids. A retrospective cohort study was conducted using a large UK primary care database (the General Practice Research Database [GPRD]). Inhaled corticosteroid users aged 18 years or older were compared matched control patients and group noncorticosteroid bronchodilator users. Patients concomitant use excluded. The comprised 170,818 users,...
Objective. This study examined the effects of daily and cumulative oral corticosteroid doses on risk fractures.
A population-based British cohort study, including approximately 6% of the population, was used to derive age- and sex-specific incidence rates fractures during childhood. Fractures were more common among boys than girls, with peak incidences at 14 11 years age, respectively. At childhood peak, only surpassed later in life 85 age women never men.Fractures account for 25% accidents injuries childhood; however, descriptive epidemiology remains uncertain.Age- various skeletal sites derived from...
To determine whether patients with rheumatoid arthritis (RA) have an increased risk of fracture, and to estimate their long-term absolute fracture risk.We studied RA ages >or=40 years in the British General Practice Research Database, each matched by age, sex, calendar time, practice 3 control patients. Incident fractures, as recorded computerized medical records, were ascertained over a median followup 7.6 years. The rate compared controls was adjusted for smoking, body mass index (BMI),...
Abstract Objective To evaluate predictors of vertebral fractures, including a threshold for bone mineral density (BMD), in patients receiving oral glucocorticoids (GCs). Methods Data were obtained from 2 randomized clinical trials (prevention and treatment risedronate) using similar methods, but different inclusion criteria applied with regard to prior exposure GCs. Predictors fracture the placebo group identified Cox regression forward selection. The BMD analysis involved comparison 1‐year...
Administration of oral corticosteroids is associated with the development osteoporosis and an increased risk fractures. However, size treated sub‐population who would benefit from preventive therapy remains uncertain. The objective this study was to investigate usage pattern in a large sample representative general population England Wales. Information obtained General Practice Research Database (GPRD) which contains medical records practitioners. Oral corticosteroid users were patients aged...
<b>Objective:</b> To assess whether use of oral glucocorticoids is associated with cardiovascular and cerebrovascular morbidity. <b>Design setting:</b> Nested case–control study within a cohort patients (⩾ 50 years old) at least one prescription for or non-systemic glucocorticoids. Data were from the general practice research database. <b>Patients:</b> 656 identified first record ischaemic heart disease (<i>International classification diseases</i>, ninth revision (ICD-9) codes 410, 411,...
BackgroundEthnicity recording across the National Health Service (NHS) has improved dramatically over past decade. This study profiles completeness, consistency and representativeness of routinely collected ethnicity data in both primary care hospital settings.
Summary Atrial fibrillation (AF) carries an increased risk of ischaemic stroke, and oral anticoagulation with warfarin can reduce this risk. The objective study was to evaluate the association between time in therapeutic International Normalised Ratio (INR) range when receiving stroke mortality. cohort included AF patients aged 40 years older UK General Practice Research Database. For treated we computed percentage follow-up spent within range. Cox regression used assess INR outcomes while...
<b>Objective</b> To determine the completeness and diagnostic validity of myocardial infarction recording across four national health record sources in primary care, hospital a disease registry, mortality register. <b>Design</b> Cohort study. <b>Participants</b> 21 482 patients with acute England between January 2003 March 2009, identified prospectively collected, linked electronic sources: Clinical Practice Research Datalink (primary care data), Hospital Episode Statistics (hospital...
Cohort evidence linking long-term exposure to outdoor particulate air pollution and mortality has come largely from the United States. There is relatively little nationally representative cohorts in other countries.
Evidence based largely on US cohorts suggests that long-term exposure to fine particulate matter is associated with cardiovascular mortality. There less evidence for other pollutants and morbidity. By using a cohort of 836,557 patients age 40 89 years registered 205 English general practices in 2003, we investigated relationships between ambient outdoor air pollution incident myocardial infarction, stroke, arrhythmia, heart failure over 5-year period.Events were identified from primary care...
Objectives Overutilisation of antibiotics may contribute to the emergence antimicrobial drug resistance, a growing international concern. This study aimed analyse performance UK general practices with respect antibiotic prescribing for respiratory tract infections (RTIs) among young and middle-aged adults. Setting Data are reported 568 contributing Clinical Practice Research Datalink. Participants were adults aged 18–59 years. Consultations identified acute upper RTIs including colds, cough,...
What was already known .Primary care databases, containing validated data coded in electronic medical records provide a powerful source of for epidemiological research. .Several methods have been used to assess the completeness and accuracy registers such data.What this study added our knowledge .We report, first time, usefulness rate comparison as valid method establishing researchusable within primary records. also introduce SIDIAP scientific community.SIDIAP is one few databases...