Adam Timmis
A5079795046- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical industry and healthcare
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Academic Publishing and Open Access
- Lipoproteins and Cardiovascular Health
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Misinformation and Its Impacts
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Health and Risk Factors
- Healthcare cost, quality, practices
- scientometrics and bibliometrics research
- Global Public Health Policies and Epidemiology
- Health and Medical Research Impacts
Queen Mary University of London
2016-2025
William Harvey Research Institute
2011-2024
Barts Health NHS Trust
2011-2021
St Bartholomew's Hospital
2005-2021
Keele University
2019-2021
British Heart Foundation
2017-2019
University College London
2002-2019
Regeneron (United States)
2019
AstraZeneca (France)
2019
The University of Texas Southwestern Medical Center
2019
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient where necessary patient's guardian or carer.It is also professional's verify rules regulations applicable drugs...
The associations of blood pressure with the different manifestations incident cardiovascular disease in a contemporary population have not been compared. In this study, we aimed to analyse 12 presentations disease.
BackgroundThe contemporary associations of type 2 diabetes with a wide range incident cardiovascular diseases have not been compared. We aimed to study between and 12 initial manifestations disease.MethodsWe used linked primary care, hospital admission, disease registry, death certificate records from the CALIBER programme, which links data for people in England recorded four electronic health sources. included who were (or turned) 30 years or older Jan 1, 1998, March 25, 2010, free at...
Abstract Aims The 2019 report from the European Society of Cardiology (ESC) Atlas provides a contemporary analysis cardiovascular disease (CVD) statistics across 56 member countries, with particular emphasis on international inequalities in burden and healthcare delivery together estimates progress towards meeting 2025 World Health Organization (WHO) non-communicable targets. Methods results In this report, CVD are presented for countries ESC. drawn ESC which is repository data variety...
Abstract Aims This report from the European Society of Cardiology (ESC) Atlas Project updates and expands upon widely cited 2019 in presenting cardiovascular disease (CVD) statistics for 57 ESC member countries. Methods results Statistics pertaining to 2019, or latest available year, are presented. Data sources include World Health Organization, Institute Metrics Evaluation, Bank, novel sponsored data on human capital infrastructure healthcare delivery. New material this includes...
The European Society of Cardiology (ESC) Atlas has been compiled by the Heart Agency to document cardiovascular disease (CVD) statistics 56 ESC member countries. A major aim this 2017 data presentation compare high-income and middle-income countries identify inequalities in burden, outcomes, service provision. utilizes a variety sources, including World Health Organization, Institute for Metrics Evaluation, Bank risk factors, prevalence, mortality national economic indicators. It also...
Understanding and improving the prognosis of a disease or health condition is priority in clinical research practice. In this article, authors introduce framework four interrelated themes research, describe importance first these (understanding future outcomes relation to current diagnostic treatment practices), recommendations for field
Abstract Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model estimate 5- 10-year cardiovascular disease (CVD) in individuals aged over 70 years four geographical regions. Methods results Sex-specific competing risk-adjusted models for estimating CVD (CVD mortality, myocardial infarction, or stroke) were derived 65 without pre-existing atherosclerotic from Cohort Norway (28 503 individuals, 10 089 events). Models included age, smoking status,...
<b>Objective</b> To determine the completeness and diagnostic validity of myocardial infarction recording across four national health record sources in primary care, hospital a disease registry, mortality register. <b>Design</b> Cohort study. <b>Participants</b> 21 482 patients with acute England between January 2003 March 2009, identified prospectively collected, linked electronic sources: Clinical Practice Research Datalink (primary care data), Hospital Episode Statistics (hospital...
Efficacy and safety of current means to prevent cerebrovascular thrombosis in patients at high risk stroke are suboptimal. In theory, anchoring fibrinolytic plasminogen activators the luminal surface cerebral endothelium might arrest formation occlusive clots this setting. We tested approach using recombinant construct antiplatelet-endothelial cell adhesion molecule (PECAM) single-chain variable fragment (scFv)-urokinase-type activator (uPA), fusing low-molecular-weight urokinase-type with a...
The goal of cardiovascular disease (CVD) research using linked bespoke studies and electronic health records (CALIBER) is to provide evidence inform care public policy for CVDs across different stages translation, from discovery, through evaluation in trials implementation, where linkages new scientific opportunities. initial approach the CALIBER programme characterized as follows: (i) Linkages multiple heath record sources: examples include between longitudinal primary data Clinical...
Diagnosis is the traditional basis for decision-making in clinical practice. Evidence often lacking about future benefits and harms of these decisions patients diagnosed with without disease. We propose that a model practice focused on patient prognosis predicting likelihood outcomes may be more useful. Disease diagnosis can provide crucial information influence outcome serious acute illness. However, central role challenged by evidence it does not always benefit factors other than disease...
For acute myocardial infarction (AMI) without heart failure (HF), it is unclear if β-blockers are associated with reduced mortality. The goal of this study was to determine the association between β-blocker use and mortality in patients AMI HF or left ventricular systolic dysfunction (LVSD). This cohort used national English Welsh registry data from Myocardial Ischaemia National Audit Project. A total 179,810 survivors hospitalization LVSD, January 1, 2007, June 30, 2013 (final follow-up:...
Abstract Aims To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes Europe. Methods results SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 460 participants (43 706 CVD events) without previous CVD. Sex-specific competing risk-adjusted models were used including conventional factors...
Abstract Background and Aims Cardiovascular disease (CVD) impacts significantly health social care systems as well society through premature mortality disability, with patients requiring from relatives. Previous pan-European estimates of the economic burden CVD are now outdated. This study aims to provide novel, up-to-date evidence on across 27 European Union (EU) countries in 2021. Methods Aggregate country-specific resource use data morbidity, mortality, health, informal were obtained...
This report from the European Society of Cardiology (ESC) Atlas Project updates and expands upon widely cited 2019 in presenting cardiovascular disease (CVD) statistics for 57 ESC member countries.Statistics pertaining to 2019, or latest available year, are presented. Data sources include World Health Organization, Institute Metrics Evaluation, Bank, novel sponsored data on human capital infrastructure healthcare delivery. New material this includes sociodemographic environmental...
Abstract This report from the European Society of Cardiology (ESC) Atlas Project updates and expands upon 2021 in presenting cardiovascular disease (CVD) statistics for ESC member countries. paper examines inequalities healthcare outcomes countries utilizing mortality risk factor data World Health Organization Global Burden Disease study with additional economic Bank. Cardiovascular were collected by questionnaire circulated to national cardiac societies Statistics pertaining 2022, or latest...
Ratings by an expert panel of the appropriateness treatments may offer better guidance for clinical practice than variable decisions individual clinicians, yet there have been no prospective studies outcomes. We compared outcomes patients treated medically after angiography with those who underwent revascularization, within groups defined ratings degree revascularization in varying circumstances.This was a study consecutive undergoing coronary at three London hospitals. Before were...
<h3>Abstract</h3> <b>Objective</b>To evaluate the effect of opt-in compared with opt-out recruitment strategies on response rate and selection bias. <b>Design</b>Double blind randomised controlled trial. <b>Setting</b>Two general practices in England. <b>Participants</b>510 patients angina. <b>Intervention</b>Patients were randomly allocated to an (asked actively signal willingness participate research) or (contacted repeatedly unless they signalled unwillingness participate) approach for...