A5079237983- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Nutritional Studies and Diet
- Health disparities and outcomes
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Chronic Disease Management Strategies
- Physical Activity and Health
- Sodium Intake and Health
- Obesity, Physical Activity, Diet
- Coffee research and impacts
- Research in Social Sciences
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Pneumonia and Respiratory Infections
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
University of Oulu
2015-2024
Oulu University Hospital
2015-2024
Northern Ostrobothnia Hospital District
2024
University of Helsinki
2005-2022
Helsinki University Hospital
2022
Imperial College London
2003-2021
City Hospital
2011-2021
The George Institute for Global Health
2019
UNSW Sydney
2019
Johns Hopkins University
2019
Whether the treatment of patients with hypertension who are 80 years age or older is beneficial unclear. It has been suggested that antihypertensive therapy may reduce risk stroke, despite possibly increasing death.We randomly assigned 3845 from Europe, China, Australasia, and Tunisia were had a sustained systolic blood pressure 160 mm Hg more to receive either diuretic indapamide (sustained release, 1.5 mg) matching placebo. The angiotensin-converting-enzyme inhibitor perindopril (2 4 mg),...
Recent reports suggest that calcium-channel blockers may be harmful in patients with diabetes and hypertension. We previously reported antihypertensive treatment the blocker nitrendipine reduced risk of cardiovascular events. In this post hoc analysis, we compared outcome diabetic nondiabetic patients.
Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland.Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria CAIDE Dementia Risk Score ≥6 performance the mean level or slightly lower than expected for age (but not substantial impairment) assessed with Consortium Establish Registry Alzheimer's...
OBJECTIVE—To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. RESEARCH DESIGN AND METHODS—We prospectively followed 51,552 Finnish men and women 25–74 years of age without history disease baseline. History other study parameters were determined using standardized measurements. Ascertainment the status was based on nationwide Social Insurance Institution's drug register data. Hazard ratios incident associated with estimated. RESULTS—During mean follow-up...
Abstract Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model estimate 5- 10-year cardiovascular disease (CVD) in individuals aged over 70 years four geographical regions. Methods results Sex-specific competing risk-adjusted models for estimating CVD (CVD mortality, myocardial infarction, or stroke) were derived 65 without pre-existing atherosclerotic from Cohort Norway (28 503 individuals, 10 089 events). Models included age, smoking status,...
Abstract Introduction The 2‐year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced Methods FINGER recruited 1260 people from the general population (60–77 years, at risk for dementia). Participants were randomized 1:1 (diet,...
The role of the apolipoprotein E (APOE) ε4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear.To examine whether APOE modifies previously reported significant benefits a multidomain intervention (prespecified subgroup analysis).The Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) was randomized clinical trial 6 centers across Finland (screening randomization performed from September 7, 2009,...
Abstract Several prospective studies have assessed the association between coffee consumption and Parkinson's disease (PD) risk, but results are inconsistent. We examined of tea with risk incident PD among 29,335 Finnish subjects aged 25 to 74 years without a history at baseline. During mean follow‐up 12.9 years, 102 men 98 women developed an PD. The multivariate‐adjusted (age, body mass index, systolic blood pressure, total cholesterol, education, leisure‐time physical activity, smoking,...
To examine the association between serum total cholesterol at baseline and risk of Parkinson disease (PD).Study cohorts included 24,773 Finnish men 26,153 women aged 25 to 74 years without a history PD stroke baseline. Hazard ratios (HRs) incident were estimated for different levels cholesterol.During mean follow-up period 18.1 years, 321 304 developed PD. After adjustment confounding factors (age, study body mass index, systolic blood pressure, education, leisure-time physical activity,...
<b>Objective: </b> To examine the association between body mass index (BMI) and risk of Parkinson disease (PD). <b>Methods: Study cohorts included 22,367 Finnish men 23,439 women 25 to 59 years age without a history PD at baseline. Hazards ratios (HRs) incident were estimated for different levels BMI. <b>Results: During mean follow-up period 18.8 years, 272 254 developed PD. After adjustment confounding factors (age, study systolic blood pressure, total cholesterol, education, leisure-time...
Background and Purpose— Both hypertension diabetes are strong predictors of stroke, but very few studies have assessed their joint effect on stroke risk. We evaluated prospectively the association history type 2 incidence mortality. Methods— followed 49 582 Finnish subjects aged 25 to 74 years without a coronary heart disease at baseline. Hazards ratios (HRs) for risk were estimated by status. Results— During mean follow-up 19.1 years, 2978 incident events recorded, which 924 fatal. Age-,...
Obesity increases heart failure (HF) risk; however, the independent effect of physical activity and joint adiposity on HF risk are not established. We evaluated single associations different indicators (body mass index, waist circumference, waist-to-hip ratio) with risk.Study cohorts included 59 178 Finnish participants who were 25 to 74 years age free at baseline. During a mean follow-up 18.4 years, 1921 men 1693 women developed HF. The multivariable-adjusted hazard ratios associated low,...
The association of total and high-density lipoprotein (HDL) cholesterol with stroke risk is unclear, especially regarding hemorrhagic stroke.We prospectively investigated the associations serum HDL total/HDL ratio type-specific incidence among 58,235 Finnish people aged 25 to 74 years free coronary heart disease at baseline.During a mean follow-up period 20.1 years, 3914 participants developed events (3085 ischemic, 497 intracerebral hemorrhage, 332 subarachnoid hemorrhage)....
Cardiovascular risk factors, such as diabetes mellitus and central obesity, have been associated with Parkinson disease (PD), but data on blood pressure PD are lacking. We sought to examine the association of hypertension among men women. This study consisted 7 surveys (1972–2002) representative samples general population in Finland (National FINRISK Study). A total number 59 540 participants (age 25 74 years; 51.8% women) who were free stroke at baseline prospectively followed until...
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for 2-year multimodal intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports exploratory analyses of brain MRI measures. FINGER targeted 1260 older individuals from the general population. Participants were 60–77 years old, at...
Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how adherence affects cognition in FINGER trial (pre-specified subgroup analyses).FINGER a multicenter randomized controlled examining efficacy multidomain (ClinicalTrials.gov NCT01041989). A total 1260 participants aged 60 to 77 with increased dementia risk were control groups. Percentage completed sessions, change score (self-reported...
Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) we assessed this lifestyle intervention incident CVD (pre-specified secondary outcome).FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials.gov NCT01041989). They were randomized (1:1) 2-year multi-domain with diet,...
To determine the risk of death from coronary heart disease, stroke, all cardiovascular disease and all-cause mortality associated with systolic blood pressure in particular isolated hypertension among middle-aged population.A prospective 15-year cohort study two independent cross-sectional random samples subjects participating baseline surveys 1972 1977. Each survey included a self-administered questionnaire, measurements height, weight determination serum cholesterol concentration.North...
To describe the secular changes in prevalence, awareness, treatment and control of hypertension. Two independent cross-sectional population surveys using standardized methods conducted between early 1980s mid-1990s. Twenty-four geographically defined populations WHO MONICA Project. Randomly selected men women aged 35–64 years. The total number participants was 69 907. definitions hypertension were used: 160/95 mmHg or above 140/90 for systolic diastolic blood pressure. Subjects on...
Background— The role of lifestyle factors in explaining the risk heart failure (HF) is not properly established. Methods and Results— national population-based study included 18 346 Finnish men 19 729 women who were 25 to 74 years age free HF at baseline. Multivariable Cox proportional hazards regression models was used examine association between (smoking, body mass index [BMI], physical activity, vegetable consumption, fruit alcohol consumption) risk. During a median follow-up 14.1...
Our aim is to describe the study recruitment and baseline characteristics of Finnish Geriatric Intervention Study Prevent Cognitive Impairment Disability (FINGER) population. Potential participants (age 60–77 years, dementia risk score ≥6) were identified from previous population-based survey cohorts invited screening visit. To be eligible, cognitive performance measured at visit had mean level or slightly lower than expected for age. Of those (n = 5496), 48% 2654) attended visit, finally...
Objectives To determine whether leisure‐time physical activity ( LTPA ) is independently associated with all‐cause and cardiovascular mortality incidence of disease CVD stroke in older adults. Design Population‐based cohort study (median follow‐up 11.8 years). Setting Community, five Finnish provinces. Participants Men women aged 65 to 74 who participated a baseline risk factor survey between 1997 2007 Finland (N = 2,456). Measurements The protocol included self‐administered questionnaire,...
Abstract Introduction Association between healthy diet and better cognition is well established, but evidence limited to evaluate the effect of dietary changes adopted in older age. Methods We investigated role Finnish Geriatric Intervention Study Prevent Cognitive Impairment Disability (FINGER) with 1260 at‐risk participants (60–77 years) who were randomized intensive multidomain intervention (including counseling) or regular health advice for 2 years. Parallel process latent growth curves...