Riyaz Patel
A5073698080- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Chronic Disease Management Strategies
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Health Promotion and Cardiovascular Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Primary Care and Health Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Machine Learning in Healthcare
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
University College London
2016-2025
St Bartholomew's Hospital
2016-2025
Barts Health NHS Trust
2015-2025
National Institute for Health Research
2017-2025
UCL Biomedical Research Centre
2019-2024
University College London Hospitals NHS Foundation Trust
2018-2024
Narsee Monjee Institute of Management Studies
2024
CHI Health Creighton University Medical Center - Bergan Mercy
2024
Health Data Research UK
2018-2023
British Heart Foundation
2019-2023
Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes not been evaluated comprehensively, because available studies have involved limited scope sample sizes. This study sought construct score for estimate its as screening tool primary prevention. Using meta-analytic approach combine large-scale, genome-wide, targeted genetic association data, we developed new (metaGRS) consisting 1.7...
Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, inference undermined if genetic variants used instrument a factor also influence alternative disease-pathways (horizontal pleiotropy). Here we report how 'no horizontal pleiotropy assumption' strengthened when proteins are interest. Proteins typically proximal effectors processes encoded in genome. Moreover, targets most medicines, so...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Abstract Objective Electronic health records (EHRs) are a rich source of information on human diseases, but the is variably structured, fragmented, curated using different coding systems, and collected for purposes other than medical research. We describe an approach developing, validating, sharing reproducible phenotypes from national structured EHR in United Kingdom with applications translational Materials Methods implemented rule-based phenotyping framework, up to 6 approaches...
To clarify the performance of polygenic risk scores in population screening, individual prediction, and stratification.
Several sequence variants are known to have effects on serum levels of non–high-density lipoprotein (HDL) cholesterol that alter the risk coronary artery disease.
Cardiac death is the leading cause of mortality in patients with sarcoidosis, yet cardiac involvement often remains undetected. Cardiovascular magnetic resonance imaging (CMR) and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) have been used to diagnose sarcoidosis (CS) never simultaneously a cohort. This study sought assess diagnostic prognostic utility simultaneous hybrid PET/MR.Fifty-one consecutive suspected CS (age 50 ± 13 years, 31 males) underwent PET/MR following...
Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent creatinine-based renal function measurements. It unclear whether this relationship causal, arises from residual confounding, and/or a consequence reverse causation. The aim study was to use Mendelian randomization investigate causally related CVD in the general population. We incorporated participant data 16 prospective cohorts (n = 76,481) 37,126 measures and...
Background Young women with coronary heart disease have high rates of depression and a higher risk adverse events than men similar age. Whether has prognostic value in this group older is not known. Our objective was to assess whether young associated artery ( CAD ) outcomes compared similarly aged women. Methods Results We examined 3237 patients undergoing angiography for evaluation followed them 2.9 years (median). Depressive symptoms were assessed the Patient Health Questionnaire PHQ )‐9,...
Abstract Aims The prognosis of patients hospitalized for worsening heart failure ( HF ) is well described, but not that managed solely in non‐acute settings such as primary care or secondary outpatient care. We assessed the distribution across levels healthcare, and prognostic differences with either recorded (including care) PC ), hospital admissions alone, known both contexts. Methods results This study was part CALIBER programme, which comprises linked data from care, admissions, death...
•Variants in metal ion transporter and NAFLD genes are associated with liver MRI-derived cT1, a steatohepatitis fibrosis proxy.•cT1 is highly heritable, correlated BMI, VLDL, inversely HDL.•Insulin resistance, higher BMI genetically linked to whilst favourable adiposity lower cT1. Background & AimsMRI-based corrected T1 (cT1) non-invasive method grade the severity of fibrosis. We aimed identify genetic variants influencing cT1 use genetics understand mechanisms underlying fibroinflammatory...
Abstract Following numerous genome-wide association studies of disease susceptibility, there is increasing interest in genetic associations with prognosis, survival or other subsequent events. Such are vulnerable to index event bias, by which selection subjects according status creates biased if common causes incidence and prognosis not accounted for. We propose an adjustment for bias using the residuals from regression effects on incidence. Our approach eliminates this when direct...
Background National electronic health records (EHR) are increasingly used for research but identifying disease cases is challenging due to differences in information captured between sources (e.g. primary and secondary care). Our objective was provide a transparent, reproducible model integrating these data using atrial fibrillation (AF), chronic condition diagnosed managed multiple ways different healthcare settings, as case study. Methods Potentially relevant codes AF screening, diagnosis,...
BackgroundPrevious trials suggest lower long-term risk of mortality after invasive rather than non-invasive management patients with non-ST elevation myocardial infarction (NSTEMI), but the excluded very elderly patients. We aimed to estimate effect versus within 3 days peak troponin concentration on survival aged 80 years or older NSTEMI.MethodsRoutine clinical data for this study were obtained from five collaborating hospitals hosting NIHR Biomedical Research Centres in UK (all tertiary...
Abstract Objective To determine the relation between age and troponin level its prognostic implication. Design Retrospective cohort study. Setting Five cardiovascular centres in UK National Institute for Health Research Informatics Collaborative (UK-NIHR HIC). Participants 257 948 consecutive patients undergoing testing any clinical reason 2010 2017. Main outcome measure All cause mortality. Results had measured during study period. Analyses on were performed using peak level, which was...
Introduction Lung cancer screening (LCS) by low-dose computed tomography (LDCT) offers an opportunity to impact both lung and coronary heart disease mortality through detection of artery calcification (CAC). Here, we explore the value CAC cardiovascular (CVD) risk assessment in LCS participants Screen Uptake Trial (LSUT). Methods In this cross-sectional study, current ex-smokers aged 60–75 were invited a ‘lung health check’. Data collection included CVD enabling estimation 10 year using...