A5058374848- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Obesity, Physical Activity, Diet
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Nutritional Studies and Diet
- Functional Brain Connectivity Studies
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Chronic Disease Management Strategies
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Health disparities and outcomes
- Cognitive Abilities and Testing
- Tryptophan and brain disorders
- Sleep and related disorders
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury Research
University of Glasgow
2016-2025
Jazan University
2024
University of Edinburgh
2012-2024
Health Affairs
2024
Ministero della Salute
2024
Karolinska Institutet
2019-2022
Public Health Scotland
2021
GTx (United States)
2020
University of Ulster
2019
King's College London
2019
Abstract Objective To investigate the association of grip strength with disease specific incidence and mortality whether enhances prediction ability an established office based risk score. Design Prospective population study. Setting UK Biobank. Participants 502 293 participants (54% women) aged 40-69 years. Main outcome measures All cause as well from cardiovascular disease, respiratory chronic obstructive pulmonary cancer (all cancer, colorectal, lung, breast, prostate). Results Of...
<b>Objective</b> To investigate the association between active commuting and incident cardiovascular disease (CVD), cancer, all cause mortality. <b>Design</b> Prospective population based study. <b>Setting</b> UK Biobank. <b>Participants</b> 263 450 participants (106 674 (52%) women; mean age 52.6), recruited from 22 sites across UK. The exposure variable was mode of transport used (walking, cycling, mixed <i>v</i> non-active (car or public transport)) to commute work on...
People's differences in cognitive functions are partly heritable and associated with important life outcomes. Previous genome-wide association (GWA) studies of have found evidence for polygenic effects yet, to date, there few replicated genetic associations. Here we use data from the UK Biobank sample investigate contributions variation tests three educational attainment. GWA analyses were performed verbal–numerical reasoning (N=36 035), memory (N=112 067), reaction time (N=111 483)...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Abstract Aims Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular (VRFs) detailed aspects of brain macrostructure microstructure in large community-dwelling populations across middle older age. Methods results Associations VRFs (smoking, hypertension, pulse pressure, diabetes, hypercholesterolaemia, body mass index, waist–hip ratio) structural diffusion MRI markers were examined UK...
Cannabis use is observationally associated with an increased risk of schizophrenia, but whether the relationship causal not known. Using a genetic approach, we took 10 independent variants previously identified to associate cannabis in 32 330 individuals determine nature association between and schizophrenia. Genetic were employed as instruments recapitulate randomized controlled trial involving two groups (cannabis users vs nonusers) estimate effect on schizophrenia 34 241 cases 45 604...
Higher body mass index (BMI) is a risk factor for cardiometabolic disease; however, the underlying causal associations remain unclear.To use UK Biobank data to report estimates of association between BMI and disease outcomes traits, such as pulse rate, using mendelian randomization.Cross-sectional baseline from population-based cohort study including 119 859 participants with complete phenotypic (medical sociodemographic) genetic data. Participants attended 1 22 assessment centers across...
It is unclear whether the potential benefits of physical activity differ according to level cardiorespiratory fitness (CRF) or strength. The aim this study was determine association between and mortality moderated by CRF grip strength sufficiently inform health promotion strategies. 498 135 participants (54.7% women) from UK Biobank were included (CRF data available in 67 702 participants). Exposure variables strength, CRF, activity. All-cause cardiovascular disease (CVD) events outcomes....
The data regarding the associations of body mass index (BMI) with cardiovascular (CVD) risk, especially for those at low categories BMI, are conflicting. aim our study was to examine composition (assessed by five different measures) incident CVD outcomes in healthy individuals.A total 296 535 participants (57.8% women) white European descent without baseline from UK biobank were included. Exposures measures adiposity. Fatal and non-fatal events primary outcome. Low BMI (≤18.5 kg m-2)...
Total cholesterol and high-density lipoprotein (HDL-C) measurements are central to cardiovascular disease (CVD) risk assessment, but there is continuing debate around the utility of other lipids for prediction.
Abstract Objective To investigate the association of macronutrient intake with all cause mortality and cardiovascular disease (CVD), implications for dietary advice. Design Prospective population based study. Setting UK Biobank. Participants 195 658 502 536 participants in Biobank completed at least one questionnaire were included analyses. Diet was assessed using Oxford WebQ, a web 24 hour recall questionnaire, nutrient intakes estimated standard methodology. Cox proportional models...
BackgroundDementia is associated with a high burden of dependency and disability. Physical frailty (hereafter referred to as frailty) multisystem dysregulation that has been identified risk factor for dementia. The aim this study was examine the association its individual components all-cause dementia incidence in cohort UK adults.MethodsParticipants Biobank data available without any form at baseline were included prospective study. Frailty defined using modified version phenotype based on...
The association between loneliness and suicide is poorly understood. We investigated how living alone, emotional support were related to self-harm in a longitudinal design.Between 2006 2010 UK Biobank recruited assessed detail over 0.5 million people middle age. Data linked prospective hospital admission mortality records. Adjusted Cox regression models used investigate relationships arrangements, support, both as outcomes.For men, alone (Hazard Ratio (HR) 2.16, 95%CI 1.51-3.09) with...
OBJECTIVE Grip strength and diabetes are predictors of mortality cardiovascular disease (CVD), but whether these risk factors interact to predispose adverse health outcomes is unknown. This study determined the interactions between grip their association with outcomes. RESEARCH DESIGN AND METHODS We undertook a prospective, general population cohort by using UK Biobank. Cox proportional hazards models were used explore associations both all-cause CVD incidence/mortality as well test for...
Objective— Elevated white blood cell count is associated with a higher risk of cardiovascular disease (CVD). We aimed to investigate whether specific leukocyte subpopulations, which may more closely indicate inflammatory pathway, are specifically CVD. Approach and Results— Participants (478 259) from UK Biobank data for were included. Death because CVD (n=1377) non-CVD causes (n=8987) occurred during median follow-up time 7.0 years (interquartile range, 6.3–7.6). In Cox models, deciles...
Objective To investigate the association of cardiorespiratory fitness with all-cause mortality, and cardiovascular disease (CVD), respiratory disease, chronic obstructive pulmonary (COPD) cancer mortality incidence. Design Prospective population-based study. Setting UK Biobank. Participants Of 5 02 628 (5.5% response rate) participants recruited by Biobank, we included 73 259 (14.6%) available data in this analysis. these, 1374 died 4210 developed circulatory diseases, 1293 diseases 4281...
Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there limited data on whether having more than one of these conditions is associated additive effects. We aimed quantify the magnitude their associations non-demented abilities determine extent which were additive.
Apolipoprotein (APOE) e4 genotype is an accepted risk factor for accelerated cognitive aging and dementia, though its neurostructural substrates are unclear. The deleterious effects of this on brain structure may increase in magnitude into older age. This study aimed to investigate UK Biobank the association between APOE allele presence vs. absence imaging variables that have been associated with worse abilities; whether varies by cross-sectional We used magnetic resonance (MRI) genetic data...