Eske M. Derks
A5068110851- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Attention Deficit Hyperactivity Disorder
- Genetic Mapping and Diversity in Plants and Animals
- Bipolar Disorder and Treatment
- Genomic variations and chromosomal abnormalities
- Mental Health and Psychiatry
- Cannabis and Cannabinoid Research
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Genetic and phenotypic traits in livestock
- Health Systems, Economic Evaluations, Quality of Life
- Genetics, Bioinformatics, and Biomedical Research
- Genetic Syndromes and Imprinting
QIMR Berghofer Medical Research Institute
2017-2025
The University of Queensland
2022-2024
Translational Genomics Research Institute
2017-2022
Vanderbilt University Medical Center
2021
University of Amsterdam
2012-2020
Amsterdam UMC Location University of Amsterdam
2012-2020
Queensland University of Technology
2019-2020
Amsterdam Neuroscience
2012-2019
Amsterdam University Medical Centers
2018-2019
Dalhousie University
2019
Abstract Objectives Genome‐wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social sciences. However, statistical analyses will need be carefully conducted use of dedicated genetics software required. This tutorial aims provide a guideline for conducting genetic analyses. Methods We discuss explain key concepts illustrate how conduct...
Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of epigenetic influence on human traits and disease. In addition to influences age gender, genetic control DNA levels has recently been described. We used whole blood genomic in twin set (23 MZ twin-pairs 23 DZ twin-pairs, N = 92) as well healthy controls (N 96) investigate heritability relationship with gender selected profiles using readily commercially available GoldenGate bead array technology. Despite...
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify attributable all interrogated variants. We have quantified variance liability disease explained by SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded point estimate 0.58 (se = 0.09, p 5.64e-12) TS, 0.37...
Ethnic minority groups usually have a more unfavourable disease risk profile than the host population. In Europe, ethnic inequalities in health been observed relatively small studies, with limited possibilities to explore underlying causes. The aim of Healthy Life an Urban Setting (HELIUS) study is investigate causes (the unequal burden of) diseases across groups, focusing on three categories: cardiovascular diseases, mental and infectious diseases.The HELIUS prospective cohort among six...
In 1986 we began The Netherlands Twin Register (NTR) by recruiting young twins and multiples a few weeks or months after birth. Currently register around 50% of all newborn in Netherlands. Their parents receive questionnaire at registration afterwards when the children are 2, 3, 5, 7, 10 12 years age. Teachers asked to rate behavior ages years. Adolescent young-adult were recruited through City Councils early 1990s. These twins, their siblings participate longitudinal survey studies that...
Most behavior checklists for attention problems or deficit/hyperactivity disorder (ADHD) such as the Child Behavior Checklist (CBCL) have a narrow range of scores, focusing on extent to which are present. It has been proposed that measuring continuum, from positive skills problems, will add value our understanding ADHD and related problems. The Strengths Weaknesses symptoms Normal scale (SWAN) is scale. Items SWAN scored seven-point scale, with in middle 'average behavior' extremes 'far...
Background Hallucinations have consistently been associated with traumatic experiences during childhood. This association appears strongest between physical and sexual abuse auditory verbal hallucinations (AVH). It remains unclear whether mainly colour the content of AVH or childhood trauma triggers vulnerability to experience in general. In order investigate hallucinations, emotional experienced phenomenology were investigated non-psychotic individuals patients a psychotic disorder who hear...
Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex remains elusive. The authors report a combined genome-wide association study (GWAS) OCD. Method: conducted GWAS in 2,723 cases (1,310 with OCD, 834 syndrome, 579 OCD plus syndrome/chronic tics), 5,667 ancestry-matched controls, 290...