Wolfgang Maier
A5101412810- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Mental Health Research Topics
- Tryptophan and brain disorders
- Health disparities and outcomes
- Psychiatric care and mental health services
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Health and Medical Studies
- Mental Health and Psychiatry
- Mental Health Treatment and Access
- Aging and Gerontology Research
- Stress Responses and Cortisol
- Genomic variations and chromosomal abnormalities
- Psychosomatic Disorders and Their Treatments
- Frailty in Older Adults
- Receptor Mechanisms and Signaling
University of Bonn
2016-2025
University Hospital Bonn
2016-2025
German Center for Neurodegenerative Diseases
2014-2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2009-2020
SUNY Upstate Medical University
2018
Southwest Jiaotong University
2018
Shanghai Jiao Tong University
2018
Life & Brain (Germany)
2018
Wuxi People's Hospital
2018
Nanjing Medical University
2018
Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans with therapeutic potential treatment of social, cognitive, and mood disorders. However, the OT general facilitator human learning empathy unclear. The current double-blind experiments on healthy adult male volunteers investigated first whether intranasal enhanced performance feedback-guided item–category association task where either social (smiling angry faces) or nonsocial (green red lights)...
Context: Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive (MCI) condition in the course of clinical manifestation Alzheimer disease (AD).Objectives: To determine risk for conversion to any dementia, dementia AD, or vascular by SMI, graded level SMI-related worry and temporal association SMI subsequent MCI.Design: Longitudinal cohort study with follow-up examinations at 1 ⁄2 3 years after baseline.Setting: Primary care medical record registry...
Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified first strongly supported LOAD susceptibility genes since discovery involvement APOE in early 1990s. We have now exploited these GWAS datasets to uncover key pathophysiological processes. Methodology applied a recently developed tool for mining data biologically meaningful information dataset. The principal findings were then tested an independent...
<h3>Importance</h3> Medications that influence the risk of dementia in elderly can be relevant for prevention. Proton pump inhibitors (PPIs) are widely used treatment gastrointestinal diseases but have also been shown to potentially involved cognitive decline. <h3>Objective</h3> To examine association between use PPIs and incident elderly. <h3>Design, Setting, Participants</h3> We conducted a prospective cohort study using observational data from 2004 2011, derived largest German statutory...
To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory (SMI) with normal test performance.The baseline sample (n = 2892) prospective cohort study nondemented individuals (German Study on Aging, Cognition Dementia Primary Care Patients) was divided into LMCI, EMCI, SMI, control subjects by delayed recall performance. These groups were subdivided presence self-reported concerns associated experienced...
Three sets of research criteria are available for diagnosis Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, Group-2, and National Institute Aging-Alzheimer Association criteria. We compared prevalence prognosis at impairment stage according to these Subjects (n = 1607), 766 whom had both amyloid neuronal injury markers, were recruited from 13 cohorts. used test performance biomarkers classify as prodromal Group-1 Group-2 high likelihood...
Significance Sexual monogamy is potentially costly for males, and few mammalian species along with humans exhibit it. The hypothalamic peptide oxytocin (OXT) has been implicated in mediating pair bonds various species, but as yet, we know little about neurobiological factors that might act to promote fidelity, especially men. Here provide evidence a mechanism by which OXT may contribute romantic men enhancing their partner's attractiveness reward value compared other women.
To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance to investigate the longitudinal course these subjects.[¹⁸F]fluoro-2-deoxyglucose PET (FDG-PET) structural MRI were acquired 31 subjects SMI 56 controls. Cognitive follow-up testing was performed (average time: 35 months). Differences baseline brain imaging data decline assessed between both groups. Associations of tested.The group showed...
This paper provides up-to-date data on service use for mental health problems and disorders among adults aged 18-79 years in Germany derived from the Mental Health Module of German Interview Examination Survey Adults (DEGS1-MH; N=4483). Data are based exclusively self-report. Respondents were examined by clinically trained interviewers with a modified version Composite International Diagnostic DIA-X/M-CIDI to assess diagnoses according criteria DSM-IV-TR. Service use, i.e. contact care...
The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may reduce that negative ones by inhibiting amygdala activation, although it is unclear whether latter causes blunted emotional and mnemonic responses. In two independent double-blind placebo-controlled experiments, each involving over 70 healthy male subjects, we investigated OXT affects modulation startle reactivity aversive stimuli as well subsequent memory for them. Intranasal potentiated acoustic...
Background It has been suggested that clinician-rated scales and self-report questionnaires may be interchangeable in the measurement of depression severity, but it not tested whether clinically significant information is lost when assessment restricted to either or instruments. The aim this study test provides relevant short-term treatment outcomes captured by clinician-rating vice versa. Methods In genome-based drugs for (GENDEP), 811 patients with major depressive disorder treated...