Anders Wallin
A5102726792- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Health, Environment, Cognitive Aging
- Parkinson's Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- S100 Proteins and Annexins
- Frailty in Older Adults
- Peatlands and Wetlands Ecology
- Amyotrophic Lateral Sclerosis Research
- Pituitary Gland Disorders and Treatments
- Botany and Plant Ecology Studies
- Health disparities and outcomes
- Tryptophan and brain disorders
University of Gothenburg
2015-2024
Sahlgrenska University Hospital
2013-2024
Region Västra Götaland
2023
University of Oxford
2017
McLean Hospital
2015
University of New Mexico
2014
VIB-KU Leuven Center for Brain & Disease Research
2013
KU Leuven
2013
Center for Human Genetics
2013
VIB-KU Leuven Center for Cancer Biology
2013
Background and Purpose —MRI is more sensitive than CT for detection of age-related white matter changes (ARWMC). Most rating scales estimate the degree distribution ARWMC either on or MRI, they differ in many aspects. This makes it difficult to compare MRI studies. To be able study evolution possible effect drug treatment large patient samples, necessary have a scale constructed both CT. We developed evaluated new studied number patients examined with Methods —Seventy-seven were recruited...
<h3>Objectives</h3> To study the diagnostic potential of 42 amino acid form β-amyloid (β-amyloid<sub>(1-42)</sub>) in cerebrospinal fluid (CSF) as a biochemical marker for Alzheimer disease (AD), intra-individual biological variation CSF-β-amyloid<sub>(1-42)</sub>level patients with AD, and possible effects differential binding between apolipoprotein E isoforms on CSF-β-amyloid<sub>(1-42)</sub>levels. <h3>Design</h3> A 20-month prospective follow-up study. <h3>Setting</h3> Community...
Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number neurological conditions compared with healthy controls (HC) and candidate biomarker for neuroaxonal damage. The influence age sex largely unknown, levels across disorders have not been systematically to date.
Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...
Age-related white matter changes (ARWMC) on brain MRI have been associated with cognitive, motor, mood and urinary disturbances. These factors are known to contribute disability in elderly people, but the impact of ARWMC their progression transition is not determined. The LADIS (Leukoaraiosis Disability Elderly) study aims at assessing role as an independent predictor initially nondisabled (65–84 years). Subjects who impaired or only 1 item Instrumental Activity Daily Living (IADL) scale,...
Abstract Background: To simultaneously study several biomarkers for Alzheimer disease (AD), we used the xMAP™ technology to develop and evaluate a multiparametric bead-based assay quantification of β-amyloid(1–42) [Aβ(1–42)], total tau (T-TAU), hyperphosphorylated [P-TAU(181P)] in cerebrospinal fluid (CSF). Methods: We compared new multianalyte format with established ELISA techniques same proteins. then performed clinical using CSF samples from patients AD or mild cognitive impairment...
Tau protein and the 42-amino acid form of beta-amyloid (Abeta42) measured in cerebrospinal fluid (CSF) have been proposed as potential biochemical diagnostic markers for Alzheimer disease. For introduction these assays clinical practice, adequate reference values are importance.CSF samples were obtained from 231 neurologically psychiatrically healthy individuals, 21-93 years age, all with a MiniMental State examination score 28 or above. Standardized ELISAs used to measure tau Abeta42 CSF....
<b>Objective</b> To assess the impairment in daily living activities older people with age related changes white matter according to severity of these changes. <b>Design</b> Observational data collection and follow-up a cohort undergoing brain magnetic resonance imaging after non-disabling complaints. <b>Setting</b> 11 European centres. <b>Participants</b> 639 non-disabled patients (mean 74.1 (SD 5.0), 45.1% men) whom showed mild, moderate, or severe (Fazekas scale). Magnetic assessment also...
In the Leukoaraiosis and Disability (LADIS) Study, 11 European centers are evaluating role of age-related white matter changes (ARWMC) as an independent determinant transition to disability in elderly (65 84 years). We aimed at determining influence ARWMC on different objective measures gait balance.Six hundred thirty-nine nondisabled individuals were prospectively enrolled being followed-up for 3 years. Subjects graded three standardized categories (mild, moderate, severe) according central...
Three sets of research criteria are available for diagnosis Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, Group-2, and National Institute Aging-Alzheimer Association criteria. We compared prevalence prognosis at impairment stage according to these Subjects (n = 1607), 766 whom had both amyloid neuronal injury markers, were recruited from 13 cohorts. used test performance biomarkers classify as prodromal Group-1 Group-2 high likelihood...
Abstract Introduction Progress in understanding and management of vascular cognitive impairment (VCI) has been hampered by lack consensus on diagnosis, reflecting the use multiple different assessment protocols. A large multinational group clinicians researchers participated a two‐phase Vascular Impairment Cognition Classification Consensus Study (VICCCS) to agree principles (VICCCS‐1) protocols (VICCCS‐2) for diagnosis VCI. We present VICCCS‐2. Methods used VICCCS‐1 published diagnostic...
Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform procedure among others due a lack standards and guidelines minimize risk complications, such as post-LP headache or back pain.We provide consensus for LP complications. The recommendations are based on (1) data from large multicenter feasibility study (evidence level II-2), (2) systematic literature review needle characteristics...
Abstract Background We aimed to identify the most useful definition of “cerebrospinal fluid Alzheimer profile,” based on amyloid‐ß 1‐42 (Aβ 42 ), total tau, and phosphorylated tau (p‐tau), for diagnosis prognosis Alzheimer's disease (AD). Methods constructed eight profiles with previously published combinations, including regression formulas simple ratios. compared their diagnostic accuracy ability predict dementia due AD in 1385 patients from Amsterdam Dementia Cohort. Results were...
Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor directly patients. We previously showed that proteins such as synaptotagmin synaptosomal-associated protein 25 (SNAP-25) could detected pooled samples of cerebrospinal fluid, however these assays were not sensitive enough for individual samples. report a...
Abstract Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient‐acceptance of LP, incidence and risk factors for post‐LP complications clinic populations. Methods prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 5) at 23 used logistic regression analysis using generalized estimated equations to investigate complications, such as typical postlumbar headache (PLPH) back pain. Results A total...
Abstract Introduction Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none been universally accepted. These not readily comparable, impacting on rates turn prevalence estimates, research, treatment. Methods The Vascular Impairment Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries an online Delphi consensus study....
Abstract Introduction Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there no well‐established plasma markers. Methods A hypothesis‐led biomarker search was conducted in the context international multicenter studies. The discovery phase measured 53 inflammatory proteins elderly control (CTL; 259), mild cognitive impairment (MCI; 199), (262) subjects from AddNeuroMed. Results Ten analytes showed...
Background . Patients afflicted with Alzheimer's disease (AD) exhibit a decrease in the cerebrospinal fluid (CSF) concentration of 42 amino acid form of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math>-amyloid (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mtext>A</mml:mtext><mml:msub><mml:mi>β</mml:mi><mml:mrow><mml:mn>42</mml:mn></mml:mrow></mml:msub></mml:math>). However, high discrepancy between different centers measured<mml:math...