A5076707725- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Neurological and metabolic disorders
- Neonatal and fetal brain pathology
- Attention Deficit Hyperactivity Disorder
- S100 Proteins and Annexins
- Hemispheric Asymmetry in Neuroscience
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Genetic Neurodegenerative Diseases
- Genetic and Kidney Cyst Diseases
- Mitochondrial Function and Pathology
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Gothenburg
2015-2024
Sahlgrenska University Hospital
2003-2023
Karolinska Institutet
2023
Université de Picardie Jules Verne
2018
Kuopio University Hospital
2018
Juntendo University
2018
University of Eastern Finland
2018
Osaka University
2018
Neurosciences Institute
2018
Norsk Hydro (Sweden)
2016-2017
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach olfactory bulb (OB) in rodents. However, RMS adult human brain has been elusive. We demonstrate presence of a RMS, unexpectedly organized around lateral ventricular extension reaching OB, and illustrate neuroblasts it. ensheathing extension, as seen magnetic resonance imaging, cell-specific markers, electron microscopy, contains progenitor with characteristics that incorporate...
Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number neurological conditions compared with healthy controls (HC) and candidate biomarker for neuroaxonal damage. The influence age sex largely unknown, levels across disorders have not been systematically to date.
Abstract: In the present study we describe an ELISA to quantify light subunit of neurofilament triplet protein (NFL) in CSF. The method was validated by measuring CSF NFL concentrations healthy individuals and two well‐characterized groups patients with amyotrophic lateral sclerosis (ALS) Alzheimer's disease (AD). levels were increased ALS (1,743 ± 1,661 ng/L; mean SD) AD (346 176 ng/L) compared controls (138 31 p < 0.0001 for both). Within group, lower motor neuron signs only had (360...
Tau protein and the 42-amino acid form of beta-amyloid (Abeta42) measured in cerebrospinal fluid (CSF) have been proposed as potential biochemical diagnostic markers for Alzheimer disease. For introduction these assays clinical practice, adequate reference values are importance.CSF samples were obtained from 231 neurologically psychiatrically healthy individuals, 21-93 years age, all with a MiniMental State examination score 28 or above. Standardized ELISAs used to measure tau Abeta42 CSF....
The aim of this study was to determine the prevalence idiopathic normal-pressure hydrocephalus (iNPH) in elderly persons a large population-based sample using radiologic and clinical examinations.We examined representative populations aged 70 years older that had undergone neuropsychiatric evaluations CT brain between 1986 2000 (n = 1,238). Gait evaluated by examination history walking difficulty. Cognitive function with Mini-Mental State Examination urinary incontinence self-report. iNPH...
We have previously demonstrated that stroke influences systemic immune responses. The aim of the present study was to investigate patterns local inflammatory response as a consequence acute stroke.Thirty patients were studied prospectively on days 0 3, 7 9, 21 26, and after day 90 with clinical evaluations, radiological assessments, analysis serum cerebrospinal fluid cytokine levels.Significantly increased levels interleukin-6 (IL-6) in (P < .001) observed virtually all compared healthy...
SUMMARY Twenty women, who had been randomly selected from women with subclinical hypothyroidism identified in a population study were treated l ‐thyroxine and placebo double‐blind cross‐over design during 2·6 months. Three did not complete the study, one because she moved to another part of country, two nervousness sense tachycardia. None these ‘drop‐outs’ any objective signs overtreatment; they normal pulse rate serum T3 concentration within reference interval. During treatment...
<b>Objective: </b> We investigated if tau, microtubular binding protein, in serum and ventricular CSF (vCSF) patients with severe traumatic brain injury (TBI) during the initial posttraumatic days correlated to 1-year outcome. <b>Methods: Patients TBI (n = 39, Glasgow Coma Scale score ≤8) were included. measured vCSF total tau on 0 14, using ELISA. Extended Outcome (GOSE), NIH Stroke (NIHSS) neurologic status, Bartel Daily Living Index. 20) normal pressure hydrocephalus (NPH) served as...
SUMMARY A growing body of evidence points out the potential role inflammatory mechanisms in pathophysiology ischaemic brain damage. We have recently demonstrated that stroke patients display an intrathecal production proinflammatory cytokines, such as IL-1β and IL-6 already within first 24 h after beginning symptoms (Tarkowski et al., 1995). The aim present study was to investigate patterns local responses a consequence acute stroke. Thirty were studied prospectively on days 0–3, 7–9, 21–26...
Owing to all the difficulties involved in selecting patients with normal pressure hydrocephalus for shunt-operation, a cerebrospinal fluid-tap-test (CSF-TT) is introduced. Psychometric and motor capacities of are measured before after lumbar puncture removal 40-50 ml CSF. Patients fulfilling criteria were compared dementia atrophy shown by computed tomography. Normal showed temporary improvement puncture. The extent appeared be well correlated shunt operation. Accordingly, CSF-TT seems value...
ABSTRACT Seventy four consecutive patients diagnosed as normal pressure hydrocephalus (NPH) and operated with a ventriculo-peritoneal shunt were followed prospectively for an average of 2.1 years. The mean age was 64 effect the operation estimated by calculating 6 indices expression social functioning, neurological signs, gait ability, continence, psychometric performance psychiatric condition. Ninety-six % had mental symptoms, 95% disturbances 75% incontinence. Improvement observed in 78%...
Objectives To assess the 1-year outcome after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). Methods Patients (n = 142) were prospectively included European multicentre study by 13 centres. Diagnoses based solely on clinical and radiological findings. All received a programmable ventriculoperitoneal shunt. Re-examinations, 12 months surgery, performed 115 patients, was assessed modified Rankin scale (mRs) new iNPH grading scale. Improvement defined as ≥1 step...
<h3>Objective</h3> The objective was to determine the sensitivity, specificity, and positive negative predictive values of CSF Tap Test (CSF TT) resistance outflow (Rout) for outcome shunting in a sample patients with idiopathic normal pressure hydrocephalus (iNPH). <h3>Methods</h3> 115 were included this European multicentre study. Diagnosis based on clinical symptoms signs, MRI changes. All treated programmable ventriculoperitoneal shunts re-examined 12 months after surgery. Outcomes...
<h3>Objectives</h3> The natural course of idiopathic normal pressure hydrocephalus (iNPH) has not been thoroughly studied. consequences postponing shunt treatment are largely unknown. We aimed to describe the effects waiting for more than 6 months before surgery and compare outcome with that seen in patients who waited less 3 months. <h3>Methods</h3> 33 (iNPH<sub>Delayed</sub>) underwent an initial investigation (Pre-op 1), followed by re-examination, just prior surgery, after at least 2)....
Objective To present a new, continuous, calibrated and norm-based scale for the grading of severity assessment treatment outcome in idiopathic normal pressure hydrocephalus (iNPH). Patients methods A designed four domains, gait, neuropsychology, balance continence, using ordinal ratings continuous measures, was developed. Data from series 181 consecutive iNPH patients were used to calibrate parts describe distributional properties ratings. normative studies determine limits scores. Results...
This observational study aimed to explore the pathophysiology of idiopathic normal-pressure hydrocephalus (iNPH) and evaluate diagnostic prognostic value CSF biomarkers.Lumbar patients with iNPH healthy elderly individuals (HI) ventricular (VCSF) from pre 6 months postsurgery were analyzed by ELISA. We neurofilament light protein (NFL), myelin basic (MBP), a panel β-amyloid isoforms (Aβ38, Aβ40, Aβ42), soluble amyloid precursor (sAPP) sAPPα sAPPβ, total phosphorylated tau (t- p-tau),...
<h3>Objective:</h3> We examined clinical and imaging findings of suspected idiopathic normal pressure hydrocephalus (iNPH) in relation to vascular risk factors white matter lesions (WMLs), using a nested case-control design representative, population-based sample. <h3>Methods:</h3> From sample, 1,235 persons aged 70 years or older were with CT the brain between 1986 2000. identified 55 hydrocephalic ventricular enlargement, i.e., radiologic consistent iNPH. Among these, 26 had signs that...
To assess the complete vascular risk factor (VRF) profile of idiopathic normal pressure hydrocephalus (INPH) using a large sample representative patients with INPH and population-based controls to determine extent which disease influences pathophysiology.All who underwent shunting in Sweden 2008-2010 were compared age- sex-matched controls. Inclusion criteria age 60-85 years no dementia. The 10 most important VRFs cerebrovascular peripheral prospectively assessed blood samples, clinical...
Objective To examine the differential diagnostic significance of cerebrospinal fluid (CSF) biomarkers reflecting Alzheimer’s disease-related amyloid β (Aβ) production and aggregation, cortical neuronal damage, tau pathology, damage to long myelinated axons astrocyte activation, which hypothetically separates patients with idiopathic normal pressure hydrocephalus (iNPH) from other neurodegenerative disorders. Methods The study included lumbar CSF samples 82 iNPH, 75 vascular dementia, 70...
Very divergent prevalence rates for idiopathic normal pressure hydrocephalus (iNPH) are reported, probably due to differences in study sample selection and diagnostic criteria. This MRI-based aimed determine the of iNPH iNPH-specific radiologic changes their association with clinical symptoms a large, 70-year-old population-based cohort (Gothenburg H70).
The present study examines the extent of spinal cerebrospinal fluid (CSF) absorption in healthy individuals relation to physical activity, CSF production, intracranial pressure (ICP), and movement. Thirty-four aged 21-35 yr were examined by lumbar puncture radionuclide cisternography with repeated imaging. ICP was registered before after drainage, production calculated. Spinal calculated as reduction activity. activity subarachnoidal space gradually decreased 20 +/- 13% (mean SD) during 1 h....
Analyses of the cerebrospinal fluid (CSF) to determine blood-CSF barrier function and detect intrathecal IgG production are used in diagnosis neurological psychiatric diseases. Therefore, accurate reference values for these parameters utmost importance. However, current based on 'reference groups' consisting patients with and/or symptoms but without positive clinical findings groups young students. The present study presents CSF proteins a large sample (n = 105) healthy individuals, age-span...