A5088282584- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- RNA Research and Splicing
- Barrier Structure and Function Studies
- Amyotrophic Lateral Sclerosis Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Immune cells in cancer
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
University of Auckland
2016-2025
Brain Research New Zealand
2015-2023
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Hudson Institute
2023
The University of Adelaide
2002-2020
Royal Adelaide Hospital
2002-2019
MedTech CoRE
2018
University Radiology
2015
Karolinska Institutet
2013
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach olfactory bulb (OB) in rodents. However, RMS adult human brain has been elusive. We demonstrate presence of a RMS, unexpectedly organized around lateral ventricular extension reaching OB, and illustrate neuroblasts it. ensheathing extension, as seen magnetic resonance imaging, cell-specific markers, electron microscopy, contains progenitor with characteristics that incorporate...
Huntington's disease (HD) pathology is well understood at a histological level but comprehensive molecular analysis of the effect in human brain has not previously been available. To elucidate phenotype HD on genome-wide scale, we compared mRNA profiles from 44 brains with those 36 unaffected controls using microarray analysis. Four regions were analyzed: caudate nucleus, cerebellum, prefrontal association cortex [Brodmann's area 9 (BA9)] and motor 4 (BA4)]. The greatest number magnitude...
Neurogenesis has recently been observed in the adult human brain, suggesting possibility of endogenous neural repair. However, augmentation neurogenesis brain response to neuronal cell loss not demonstrated. This study was undertaken investigate whether occurs subependymal layer (SEL) adjacent caudate nucleus neurodegeneration Huntington's disease (HD). Postmortem control and HD tissue were examined by using cycle marker proliferating nuclear antigen (PCNA), βIII-tubulin, glial fibrillary...
The PARK8 gene responsible for late-onset autosomal dominant Parkinson's disease encodes a large novel protein of unknown biological function termed leucine-rich repeat kinase 2 (LRRK2). studies herein explore the localization LRRK2 in mammalian brain.Polyclonal antibodies generated against amino or carboxy termini were used to examine biochemical, subcellular, and immunohistochemical distribution LRRK2.LRRK2 is detected rat brain as an approximate 280kDa by Western blot analysis....
Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It caused by CAG repeat expansion in exon 1 of the HTT gene translates to polyglutamine tract huntingtin protein (HTT). The formation fragments has been implicated as an essential step molecular pathogenesis HD several proteases cleave have identified. However, importance smaller N-terminal highlighted their presence...
To test the hypotheses that mutant huntingtin protein length and wild-type dosage have important effects on disease-related transcriptional dysfunction, we compared changes in mRNA seven genetic mouse models of Huntington's disease (HD) postmortem human HD caudate. Transgenic expressing short N-terminal fragments (R6/1 R6/2 mice) exhibited most rapid gene expression, consistent with previous studies. Although brains knock-in full-length transgenic took longer to appear, 15- 22-month...
Papertrinucleotide repeat expansion resulting in an elongated polyglutamine stretch near the N-terminus of huntingtin (HTT) protein [2].HD patients have CAG lengths greater than 36 on one HTT alleles.Although HD affects a number brain regions such as cortex, thalamus, and subthalamic nucleus, www.impactaging.com
Abstract We have previously shown that exon 1 of the huntingtin gene does not always splice to 2 resulting in production a small polyadenylated mRNA ( HTTexon1 ) encodes highly pathogenic HTT protein. The level this read-through product is proportional CAG repeat length and present all knock-in mouse models Huntington’s disease (HD) with lengths 50 above YAC128 BACHD models, both which express copy human gene. now developed specific protocols for quantitative analysis transcript levels...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD patients present with movement disorders, behavioral and psychiatric symptoms cognitive decline. This review summarizes the contribution of microglia astrocytes to pathophysiology. Neuroinflammation in brain characterized by a reactive morphology these glial cells. Microglia are critical regulating neuronal activity maintaining optimal milieu for function. Previous studies provide evidence that activated...
Transforming growth factor beta 1 (TGFβ1) is strongly induced following brain injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of TGFβ1 responses may therefore be beneficial in preventing inflammation neurological disorders including stroke neurodegenerative diseases. However, several other cell types display immunogenic potential identifying the effect on these cells required more fully understand its effects inflammation. Pericytes are multifunctional which...