A5046865141- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Cardiac Arrhythmias and Treatments
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Sleep and related disorders
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Cardiovascular Health and Disease Prevention
- Pancreatic function and diabetes
- Phytase and its Applications
- Hemodynamic Monitoring and Therapy
- Advanced MRI Techniques and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Gut microbiota and health
Takeda (United Kingdom)
2023
Jackson Laboratory
2018-2019
GlaxoSmithKline (United Kingdom)
2001-2013
GlaxoSmithKline (China)
2011
Institut National des Sciences Appliquées de Toulouse
2006
Centre National de la Recherche Scientifique
2006
Discovery Centre
2006
Molecular Discovery (United Kingdom)
1995-2001
New Frontier
2001
Society for Neuroscience
2000
Abstract The abdominal aorta and renal, visceral, iliac arteries were evaluated in 16 patients with three‐dimensional Fourier transform imaging enhanced gadopentetate dimeglumine. By dynamically during the arterial phase of a 5‐minute injection (0.2 mmol/kg), highly significant ( P < .0001) preferential enhancement (signal‐to‐noise ratio ± standard deviation, 10 0.9), minimal inferior vena cava (5.1 1.4) or background tissues (fat, 4.3 0.7; muscle, 2.4 0.5), was achieved every patient. In...
Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% females. This longevity extension differs from dietary restriction based on a number of features, including relatively small effects weight sex-specificity effect. By inhibiting host digestion, flux starch to lower digestive system, resulting changes gut microbiota their fermentation products. Given documented health benefits short-chain fatty acids (SCFAs), dominant...
Fractalkine is a recently identified chemokine that exhibits cell adhesion and chemoattractive properties. It represents unique member of the superfamily because it located predominantly in brain which expressed constitutively on specific subsets neurons. To elucidate possible role neuronally fractalkine inflammatory response to neuronal injury, we have analyzed regulation mRNA expression protein cleavage under conditions neurotoxicity. We observed encoding unaffected by experimental...
Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we describe of human (hVR1) cDNA containing 2517 bp open reading frame that encodes protein with 92% homology receptor-1. Oocytes mammalian cells expressing this respond capsaicin, pH and temperature generating inward membrane currents. Mammalian transfected VR1 increase in...
Melanin-concentrating hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. It implicated control of general arousal and goal-orientated behaviours mammals, appears to be key messenger regulation food intake. An understanding biological actions MCH has been so far hampered by lack information about its receptor(s) their location brain. We recently identified orphan G-protein-coupled receptor SLC-1 as for neuropeptide MCH. used situ hybridization...
Generation and deposition of the amyloid beta (Abeta) peptide following proteolytic processing precursor protein (APP) by BACE-1 gamma-secretase is central to aetiology Alzheimer's disease. Consequently, inhibition BACE-1, a rate-limiting enzyme in production Abeta, an attractive therapeutic approach for treatment We have designed selective non-peptidic inhibitor, GSK188909, that potently inhibits beta-cleavage APP reduces levels secreted intracellular Abeta SHSY5Y cells expressing APP. In...
Two genes encode the CD16 low affinity IgG FcR. CD16-I (Fc gamma RIII-1) is expressed on PMN as a phosphatidylinositol-glycan anchored glycoprotein. CD16-II RIII-2) NK cells and macrophages transmembrane glycoprotein associated with CD3 zeta or Fc epsilon RI-gamma. spontaneously release soluble from cell surface this enhanced by activation phorbol ester. In study, we demonstrate that metalloprotease involved in spontaneous PMA-induced of cells. 1,10-phenanthroline, an inhibitor...
SummaryIntravenous injections of tyramine, phenylethylamine, tryptamine, p-hydroxyamphetamine, amphetamine, ephedrine, mephentermine, and guanethidine were shown to release NE from the heart into coronary sinus blood intact anesthetized dog, while serotonin, methoxamine, phenylephrine had no such effect. A small but consistent reduction in content atrial appendage was observed following one hour's infusion tyramine. These observations furnish proof for concept that is involved pharmacologic...
The receptors for the complement anaphylatoxins C3a and C5a are expressed by glial cells neurons in normal inflamed brain. Previous studies demonstrated modest elevations mRNA expression of these a model focal cerebral ischemia. Using similar system both mice rats, we report markedly different patterns anaphylatoxin receptor was dramatically elevated within 3 h after middle artery occlusion, while C3aR reduced to 25% control animals. By 24 post-occlusion, higher than at any other time point...