A5081768582- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Atmospheric chemistry and aerosols
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Advanced Combustion Engine Technologies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Asthma and respiratory diseases
- Organic and Inorganic Chemical Reactions
- Youth Development and Social Support
- Synthesis of Organic Compounds
- Child and Adolescent Psychosocial and Emotional Development
- Combustion and flame dynamics
- Synthesis and Biological Evaluation
- Receptor Mechanisms and Signaling
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Total Knee Arthroplasty Outcomes
- Motivation and Self-Concept in Sports
- Orthopedic Infections and Treatments
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Mindfulness and Compassion Interventions
- Neurotransmitter Receptor Influence on Behavior
- Mass Spectrometry Techniques and Applications
University of South Carolina
2019-2024
University of Tennessee at Knoxville
2018
University of Cambridge
2001-2014
Houston Methodist
2005
Iowa Methodist Medical Center
2005
Methodist Hospital
2005
GlaxoSmithKline (United Kingdom)
2001
New Frontier
1992-1999
Molecular Discovery (United Kingdom)
1999
University of Central Lancashire
1997
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role ingestion. orexigenic neurones hypothalamus, however, project widely brain, and thus physiological orexins is likely to be complex. Here we describe an investigation action A modulating arousal state rats by using a combination tissue electrophysiological behavioral techniques. We show that brain region receiving densest innervation from orexinergic nerves locus coeruleus, key modulator...
SB-277011-A (trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolininecarboxamide), is a brain-penetrant, high-affinity, and selective dopamine D(3) receptor antagonist. Radioligand-binding experiments in Chinese hamster ovary (CHO) cells transfected with human or D(2 long) (hD(3), hD(2)) receptors showed to have high affinity for the hD(3) (pK(i) = 7.95) 100-fold selectivity over hD(2) 66 other receptors, enzymes, ion channels. Similar radioligand-binding...
Abstract Objectives Previous research has shown the capacity for mindfulness to be strongly associated with psychological well-being, that components of show significant growth through young adulthood, and this developing, malleable is vital as individuals learn deal appropriately negative thoughts unwelcome emotions. Smartphones, typically used in an automatic or experientially avoidant way, can undermine development, leading a decreased mindfulness. The purpose these studies were examine...
The influence of the vascular endothelium on agonist‐induced contractions and relaxations has been measured using intact segments rat aorta. Contiguous rubbed were used as controls. Angiotensin II, histamine, noradrenaline, U46619 UK 14304 contracted both tissues. threshold spasmogenic concentrations these agonists lower in tissues than preparations. sensitivity responsiveness to angiotensin noradrenaline greater Acetylcholine histamine relaxed established spasms but not those preparations,...
The mechanisms involved in the mechano‐inhibitory effects of acetylcholine (ACh) have been compared with those sodium nitroprusside (SNP) and cromakalim on rat isolated thoracic aorta. Relaxations produced by ACh were endothelium‐dependent, whereas SNP or endothelium‐independent. ACh, relaxed established contractions noradrenaline (NA) KCl (20 m ) these relaxations well‐maintained. was a relatively effective inhibitor (80 ). ineffective without effect against such contractions. Membrane...
The effects of pinacidil have been compared with those glyceryl trinitrate (GTN) using the aorta and portal vein rat trachealis taenia caeci guinea‐pig. In aorta, both GTN inhibited responses to noradrenaline showed some selective inhibition contractions 20 m K + . Responses 80 were little affected. trachealis, spontaneous tone selectively relaxed spasms unaffected. vein, completely electrical mechanical activity. reduced amplitude tension waves extracellularly‐recorded discharges, but...
The potential of the potassium channel activator, cromakalim (BRL 34915), as a bronchodilator has been evaluated in guinea‐pig models comparison with nifedipine. Some effects compounds on tracheal spirals have studied an attempt to elucidate their different efficacies vivo . When given by intraduodenal route anaesthetized guinea‐pigs, (3 and 10 mg kg −1 ) inhibited 5‐hydroxytryptamine (5‐HT)‐induced bronchospasm for at least 60 min. i.v. route, dose producing 50% inhibition 5‐HT response was...
Background: The purpose of this study was to evaluate the types and prevalence complications associated with bilateral total knee replacement performed four seven days apart during a single hospitalization compare them those sequentially under same anesthetic session or staged unilateral replacements separate hospitalizations. Methods: Using computerized database medical records, we retrospectively evaluated 332 consecutive patients who underwent by two surgeons. A 241 staggered procedures...
A number of compounds, including the selective 5‐HT 7 receptor antagonist SB‐258719, were investigated for their effect on [ 3 H]‐5‐carboxamidotryptamine (5‐CT) radioligand binding and 5‐CT‐stimulated adenylyl cyclase activity in guinea‐pig hippocampal membranes, order to confirm presence functionally coupled receptors this tissue. The H]‐5‐CT profile was consistent with predominantly receptors. affinity SB‐258719 (p K i 7.2±0.1) similar its reported human affinity. In functional assay, 5‐CT...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealisDerek R. Buckle, Jonathon S. Arch, Ashley E. Fenwick, Catherine V. Houge-Frydrych, Ivan L. Pinto, David G. Smith, Stephen Taylor, John M. TedderCite this: J. Med. Chem. 1990, 33, 11, 3028–3034Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides their analogs in guinea pig trachealisJonathan R. S. Arch, Derek Buckle, Claire Carey, Hilary Parr-Dobrzanski, Andrew Faller, Keith A. Foster, Catherine V. Houge-Frydrych, Ivan L. Pinto, David G. Smith, Stephen TaylorCite this: J. Med. Chem. 1991, 34, 8, 2588–2594Publication Date (Print):August 1, 1991Publication History Published online1 May...
Summary: In rat portal vein and aorta, pinacidil (0.3-100 μM) inhibited spontaneous mechanical activity (portal vein) responses to norepinephrine (0.001-100 KCI (5-80 mM). Pinacidil its analogs P1060 P1368 established contractions 20 mM but had little effect on 80 KCI. The order of spasmolytic potency was > P1368. Intracellular electrical recording showed that in a vein, (0.3-10 abolished hyperpolarised the cells region calculated EK. (3-10 produced similar hyperpolarisation both tissues...
The synthesis of a novel series smooth muscle relaxants which have been shown to act via the opening or activation potassium channels is described. Compounds evaluated for their ability inhibit spontaneous tone in guinea pig isolated trachealis and structure-activity relationships are discussed. One compound particular, 1,1-dimethyl-5-nitro-3-(2-pyridon-1-yl)indan-2-ol, (16) was identified as potent relaxant airways vitro with IC50 = 0.15 microM found significantly histamine-induced dyspnoea...
The Social Motivational Orientations in Sport Scale (SMOSS), developed by Allen [(2003). motivation youth sport. Journal of and Exercise Psychology, 25(4), 551–567; (2005). Measuring social motivational orientations sport: An examination the construct validity SMOSS. International 3(2), 147–161], to measure goals sport, has only been tested among late adolescent adult samples either physical education or sport setting. purpose this study was extend utility SMOSS scale examining a sample...