A5103025864- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Primary Care and Health Outcomes
- School Health and Nursing Education
- Health Policy Implementation Science
- Nursing Diagnosis and Documentation
- Health Promotion and Cardiovascular Prevention
- Food Allergy and Anaphylaxis Research
- Chronic Disease Management Strategies
- Complement system in diseases
- Coronary Interventions and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Acute Myocardial Infarction Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Family and Patient Care in Intensive Care Units
- Health, psychology, and well-being
- Pleural and Pulmonary Diseases
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Pediatric health and respiratory diseases
Shepton Mallet Community Hospital
2013-2024
Health Education North West
2023
Health Education England
2022-2023
Sanofi (France)
2022
Sanofi (United Kingdom)
2021
Capella University
2020
Queen Elizabeth Hospital Birmingham
2020
NHS England
2014-2016
Bristol Clinical Commissioning Group
2016
National Health Service
2015
<h3>Abstract</h3> <h3>Background</h3> Long Covid remains a relatively new phenomenon with emerging understanding. Estimated UK prevalence of three or more symptoms lasting for 12 weeks was 2.2% at the end 2021. The population-based French SAPRIS-SERO cohort has novel information about pattern that been obscured by controversy around original paper. <h3>Methods</h3> Secondary analysis used to describe and re-interpret persistent IgG seropositivity self-reported in survey. Participants...
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role ingestion. orexigenic neurones hypothalamus, however, project widely brain, and thus physiological orexins is likely to be complex. Here we describe an investigation action A modulating arousal state rats by using a combination tissue electrophysiological behavioral techniques. We show that brain region receiving densest innervation from orexinergic nerves locus coeruleus, key modulator...
Section 3: Clinical features which predict the presence of mesothelioma Recommendations 4: Staging systems Recommendation 5: Imaging modalities for diagnosing and staging 6: Pathological diagnosis
Sema7A is a recently described member of the semaphorin family that associated with cell surface via glycophosphatidylinositol linkage. This study examined mRNA expression and biological properties this protein. Although was demonstrated in lymphoid myeloid cells, no stimulation cytokine production or proliferation evident B T cells. In contrast, an extremely potent monocyte activator, stimulating chemotaxis at 0.1 pm inflammatory (interleukin-1 (IL-1beta), tumour necrosis factor-alpha...
The Statement addresses adults and children with the following conditions or undergoing procedures: ► Airflow obstruction including asthma COPD.► Bronchopulmonary dysplasia.► Cystic fibrosis (CF).► Non-CF bronchiectasis.► Restrictive respiratory disease interstitial lung (ILD), muscle chest wall disorders.► Thoracic surgery other interventional procedures.► Pleural pneumothorax pleural effusion.► Respiratory infections.► Obstructive sleep apnoea syndrome (OSAS) obesity hypoventilation...
Pollen-food syndrome (PFS), a food allergy affecting pollen-sensitized individuals, is likely to be the most prevalent in adults, estimated affect 50-90% of people allergic birch tree pollen.A validated PFS diagnostic questionnaire (PFSDQ2) was used determine prevalence and also characterize those who report reactions foods.Five UK General practices each sent PFSDQ2 by post 2000 patients aged 18-75 years randomly selected from their practice database. The accompanied an additional set...
Objectives Plasmacytoid dendritic cells (pDC) have been implicated in the pathogenesis of autoimmune diseases, such as scleroderma (SSc). However, this has derived from indirect evidence using ex vivo human samples or mouse pDC . We developed human-specific models to directly identify their role inflammation and fibrosis, well attenuation function with BDCA2-targeting determine its therapeutic application. Methods RNAseq TLR9 agonist ODN2216 humanised monoclonal BDCA2 antibody, CBS004....
The full guideline for the investigation and management of malignant pleural mesothelioma is published in Thorax . following a summary recommendations good practice points. sections referred to refer guideline.
Asthma is a heterogenous respiratory disease, usually associated with chronic airway inflammation and hyper-responsiveness, which affects an estimated 339 million people worldwide. Severe asthma approximately 5–10% of patients asthma, 17–34 globally, more than half whom have uncontrolled disease. carries substantial burden including unpredictable symptoms potentially life-threatening flare-ups. Furthermore, severe has on health care systems economies In 2018, group experts from the clinical...
There is a need for straightforward, novel diagnostic and monitoring technologies to enable the early diagnosis of COPD its differentiation from other respiratory diseases, establish cause acute exacerbations monitor disease progression. We sought whether already in development could potentially address these needs. A systematic horizon scanning review was undertaken identify wide range commercial non-commercial sources. Technologies were restricted those likely be available within 18...
The series on interstitial lung diseases concludes with an overview of IPF by Jane Scullion and Steve Holmes
Abstract Rationale Audit and feedback is an evidence‐based implementation strategy, but studies reporting the use of theory to guide design elements are limited. Aims Objectives Within context a programme research aiming improve supported asthma self‐management in UK primary care (IMPlementing IMProved Asthma as RouTine [IMP 2 ART]), we aimed develop theoretically‐informed audit that highlighted provision areas for improvement general practices. Method Aligned with Medical Research Council...
Abstract Background Asthma is a common long-term condition and major public health problem. Supported self-management for asthma that includes written personalised action plan, supported by regular professional review, reduces unscheduled consultations improves outcomes quality of life. However, despite unequivocal inter/national guideline recommendations, poorly implemented in practice. The IMPlementing IMProved as RouTine (IMP 2 ART) implementation strategy has been developed to address...
Severe asthma is a debilitating, life-threatening disease associated with substantial global morbidity, mortality, and health care resource utilization. Patients may not receive guideline-directed medical for severe asthma. Moreover, viable precision-based assessment tools newer preventive therapies that can reduce the frequency of exacerbations functional impact are underused. As result, high rates poorly controlled persist, patient health-related quality life suffers.In 2019, Improve...
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an ultra-rare life-threatening microangiopathy affecting adults with unpredictable disease onset and acute presentation. This study aimed to describe the health-related quality of life (HRQoL), cognitive functioning work productivity survivors following episode(s) iTTP in United Kingdom (UK).An online survey was developed collaboration TTP Network. Descriptive statistics were calculated for health questionnaire Short Form...