A5050014394- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Cardiovascular Effects of Exercise
- Stroke Rehabilitation and Recovery
- Health Systems, Economic Evaluations, Quality of Life
- Skin and Cellular Biology Research
- Health, psychology, and well-being
- School Health and Nursing Education
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Photoacoustic and Ultrasonic Imaging
- Neurological diseases and metabolism
- Cardiac pacing and defibrillation studies
Region Jönköpings län
2015-2025
Linköping University
2016-2025
Ryhov Hospital Jönköping
2012-2024
University of Gothenburg
1992-2024
Sahlgrenska University Hospital
2006-2021
Thales (Portugal)
2020-2021
Jönköping University
2010-2017
Linköping University Hospital
1992-2016
County Hospital
2011
East Kent Hospitals University NHS Foundation Trust
2010
Abstract: In the present study we describe an ELISA to quantify light subunit of neurofilament triplet protein (NFL) in CSF. The method was validated by measuring CSF NFL concentrations healthy individuals and two well‐characterized groups patients with amyotrophic lateral sclerosis (ALS) Alzheimer's disease (AD). levels were increased ALS (1,743 ± 1,661 ng/L; mean SD) AD (346 176 ng/L) compared controls (138 31 p < 0.0001 for both). Within group, lower motor neuron signs only had (360...
Retrospective studies have found that patients receiving general anesthesia for endovascular treatment in acute ischemic stroke worse neurological outcome compared with conscious sedation. In this prospective randomized single-center study, we investigated the impact of technique on patients.Ninety 2013 to 2016 were included and or Difference at 3 months, measured as modified Rankin Scale score, was analyzed (primary outcome) early improvement National Institutes Health Stroke cerebral...
Here, we present two different brain diagnostic devices based on microwave technology and the associated first proof-of-principle measurements that show systems can differentiate hemorrhagic from ischemic stroke in acute patients, as well patients healthy volunteers. The system was scattering with an antenna worn head. Measurement data were analyzed a machine-learning algorithm is training using known condition. Computer tomography images used reference. detection methodology evaluated...
Patients with myocardial infarction (MI) seldom reach recommended targets for secondary prevention. This study evaluated a smartphone application ("app") aimed at improving treatment adherence and cardiovascular lifestyle in MI patients.Multicenter, randomized trial.A total of 174 ticagrelor-treated patients were to either an interactive patient support tool (active group) or simplified (control addition usual post-MI care. Primary end point was composite nonadherence score measuring...
Background and Purpose— In retrospective studies, patients receiving general anesthesia for endovascular treatment acute ischemic stroke have worse neurological outcome compared with conscious sedation. It has been suggested that this is caused by anesthesia–associated hypotension. We investigated the effect of intraprocedural hypotension on outcome. Methods— One hundred eight stroke, who underwent in between 2007 2012, were included. Analyzed predictors age, sex, comorbidities, baseline...
Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets complex diseases, but is complicated by involvement of thousands variably expressed genes across multiple cell types. Single-cell RNA-sequencing study (scRNA-seq) allows characterization such changes in whole organs. The based on applying network tools to organize analyze scRNA-seq data from a mouse model arthritis human rheumatoid arthritis, order find diagnostic therapeutic targets....
Abstract More reliable tools are needed for the differentiation of Parkinson's disease (PD) from other parkinsonian disorders. The neurofilament protein (NFL) and glial fibrillary acidic (GFAP) main structural proteins axons astroglial cells. By using enzyme‐linked immunosorbent assays, these were quantified in cerebrospinal fluid (CSF) 49 patients referred to Department Neurology diagnostic consideration or treatment parkinsonism different etiologies. All first diagnostically evaluated by...
Female patients with congestive heart failure: how they conceive their life situation ¶Congestive failure (CHF) is a significant health problem for women, particularly elderly women. The risk factors appear to be different in women than men, hypertension and diabetes playing greater role ischaemic disease men. aim of this study was describe, from nurse’s perspective, female CHF situation. Interview questions were designed focus on five dimensions: biophysical, socio‐cultural, emotional,...
Patients with congestive heart failure (CHF) are an extensive group in Sweden both regard to prevalence and number of medical care events. As the age population survival after myocardial infarction increasing, incidence CHF is also on rise. The aim this study describe, from a nurse's perspective, how male patients conceive their life situation. Interview questions were designed focus five dimensions: biophysical, sociocultural, emotional, intellectual, spiritual‐existential. A qualitative...
Long term stress exposure is typical for modern societies and might trigger different diseases. This case-control study reveals that persons who had suffered an acute myocardial infarction (AMI) elevated cortisol concentrations in the month before event. Middle-aged patients admitted to cardiology clinics with (n = 174) were compared 3156 controls from a population-based cohort southeast Sweden. The median Hair Cortisol Concentrations (HCC) those AMI was 53.2 pg/mg 22.2 control group (p <...
Abstract Stroke is a major public health problem that can cause long-term disability or death due to brain damage. Serious stroke frequently caused by large vessel occlusion in the anterior circulation, which should be treated endovascular embolectomy if possible. In this study, we investigated use of damage biomarkers tau, NFL, NSE, GFAp, and S100B understand progression nervous tissue their relationship outcome such after treatment. Blood samples were taken from 90 patients pre-treatment 2...
Background: Apical hypertrophic cardiomyopathy (ApHCM) is a distinct variant of (HCM). Few studies have focused on the genetic determinants this subtype. We aimed to investigate basis apical hypertrophy in Swedish cohort. Methods–Results: Longitudinal data 58 unrelated index patients with ApHCM from Southeast healthcare region Sweden 2010 2024 were assessed retrospectively. Additionally, original raw testing re-evaluated using AI-based Emedgene software. Patients 47 ± 14 years old, and 60%...
Abstract The precise mechanism for the neurotoxicity of 2, 5‐hexanedione is not known, but cross‐linking neurofilament proteins has been suggested as one possibility. In this study effects long‐term exposure to were studied in rat nervous system with special reference regional changes quantities neuronal and glial intermediate filaments. Using enzyme‐linked immunosorbent assays concentrations 68‐ 200‐kDa polypeptides shown be reduced all brain regions studied. Similar results obtained...
Objective . To investigate the diagnostic accuracy and clinical benefit of point-of-care Troponin T testing (POCT-TnT) in management patients with chest pain. Design Observational, prospective, cross-sectional study followup. Setting Three primary health care (PHC) centres using POCT-TnT four PHC not southeast Sweden. Patients All ≥35 years old, contacting one for pain, dyspnoea on exertion, unexplained weakness, and/or fatigue no other probable cause than cardiac, were included. Symptoms...
Evidence of endovascular treatment (EVT) for acute large vessel occlusion (LVO) ischemic stroke in patients harboring substantial prestroke disability is lacking due to their exclusion from randomized trials. Here, we used routine care observational data compare outcomes with and without receiving EVT LVO stroke. Consecutive undergoing at the Sahlgrenska University Hospital January 1st, 2015 March 31st, 2018 were registered Stroke Recanalization Registry. Pre- poststroke functional levels...
Abstract The aim of this study was to assess changes in the sense coherence patients who had suffered their first myocardial infarction. Out 100 at start study, these were evaluated 66 men and 18 women aged 36–70 years. Generally, found be stable among whole group, but there significant individual variations its development some participants over following Even individuals with an initally high could experience a decrease level. that can explained by marital status, level treatment...
Background and purpose Recent randomized clinical trials have proved the efficacy of endovascular treatment acute ischemic stroke in anterior circulation. However, benefit posterior circulation remains to be proven since it was excluded from these trials. We evaluate strokes. Methods A total 110 consecutive patients with who underwent our institute period 1991-2015 were included. Recanalization rate according modified Treatment Cerebral Ischemia score neurological outcome at three months...
In the DETO2X-AMI trial (Determination of Role Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air normoxemic patients presenting suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report prespecified cardiovascular death composite all-cause hospitalization for heart failure.In this pragmatic, registry-based randomized clinical trial, used a...
Abstract Myocarditis most often affects otherwise healthy athletes and is one of the leading causes sudden death in children young adults. Arrhythmogenic right ventricular cardiomyopathy (ARVC) a genetically determined heart muscle disorder with increased risk for paroxysmal arrhythmias cardiac death. The clinical picture myocarditis ARVC may overlap during early stages cardiomyopathy, which lead to misdiagnosis. In literature, we found several cases that presented episodes ended up...