A5064496411- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Neuroscience of respiration and sleep
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
- Cardiovascular and Diving-Related Complications
- Cardiac and Coronary Surgery Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adenosine and Purinergic Signaling
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Whipple's Disease and Interleukins
- Polymer Nanocomposite Synthesis and Irradiation
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
Karolinska University Hospital
2014-2025
Karolinska Institutet
2016-2024
Sahlgrenska University Hospital
2003
The ACURATE neo2 is a contemporary transcatheter aortic valve implantation (TAVI) system approved for the treatment of severe stenosis in Europe. has not been evaluated bicuspid (BAV) stenosis.
To determine whether supplemental oxygen in patients with ST-elevation myocardial infarction (STEMI) impacts on procedure-related and clinical outcomes.The DETermination of the role Oxygen suspected Acute Myocardial Infarction (DETO2X-AMI) trial randomized (MI) to receive at 6 L/min for 6-12 h or ambient air. In this pre-specified analysis, we included only STEMI who underwent percutaneous coronary intervention (PCI). total, 2807 were included, 1361 assigned oxygen, 1446 The primary...
In the DETO2X-AMI trial (Determination of Role Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air normoxemic patients presenting suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report prespecified cardiovascular death composite all-cause hospitalization for heart failure.In this pragmatic, registry-based randomized clinical trial, used a...
The new-generation ACURATE neo2 system was commercially released in September 2020. In this study, we sought to compare the aortic regurgitation (AR) severity of versus neo transcatheter heart valve, using quantitative videodensitometric angiography (qAR). This is a retrospective, Corelab analysis final post-transcatheter valve implantation (TAVI) aortograms patients treated with and systems. cohort comprised consecutive between 2020 January 2021 at two centers. included before Our primary...
Abstract Background Conflicting evidence exists concerning the cardioprotective efficacy of remote ischemic conditioning as an adjunct to primary percutaneous intervention (PCI) in ST‐elevation myocardial infarction (STEMI) and data on long‐term outcomes are scarce. We evaluated final infarct size by cardiac magnetic resonance (CMR) performed 6 months after anterior STEMI treated with clinical up 3 years event. Methods One hundred fifteen patients were randomized per‐postconditioning...
Red blood cells (RBCs) are suggested to play a role in cardiovascular regulation by exporting nitric oxide (NO) bioactivity and ATP under hypoxia. It remains unknown whether such beneficial effects of RBCs protective patients with acute myocardial infarction. We investigated from ST-elevation infarction (STEMI) protect against ischemia-reperfusion injury effect involves NO purinergic signaling the RBCs. STEMI undergoing primary coronary intervention healthy controls were administered...
An 80-year-old man with a supra-annular transcatheter aortic valve (TAV) prosthesis presented severe transvalvular regurgitation 18 months after the TAV replacement procedure. The authors report first ever valve-in-valve procedure using BASILICA (bioprosthetic or native scallop intentional laceration to prevent iatrogenic coronary artery obstruction) in such prosthesis. Minimal paravalvular leakage, normal flow, and easy access were seen postimplantation. (Level of Difficulty: Advanced.).
The mechanisms underlying rupture of a coronary atherosclerotic plaque and development myocardial ischemia-reperfusion injury in ST-elevation infarction (STEMI) remain unresolved. Increased arginase 1 activity leads to reduced nitric oxide (NO) production increased formation reactive oxygen species due uncoupling the NO-producing enzyme endothelial NO synthase (eNOS). This contributes dysfunction, instability susceptibility acute infarction.The purpose this study was test hypothesis that...
Periprocedural and postinterventional care of patients undergoing closure patent foramen ovale (PFO) varies significantly across providers. Same-day discharge (SDD) after transcatheter interventions is an evolving concept. This study aimed to assess the same-day rate incidence complications in PFO with intracardiac echocardiography (ICE) using Gore®Cardioform Septal Occluder (GSO) device. The secondary aim was analyse efficacy femoral vein Perclose ProGlide.
BackgroundArterial access-site related complications constitute a large proportion of adverse events to cardiac interventions requiring large-bore devices and have significant implications on morbidity, mortality hospital cost.AimsTo evaluate the safety effectiveness novel percutaneous plug-based vascular closure device (VCD) in 1000 consecutive patients undergoing transfemoral transcatheter aortic valve implantation (TAVI).MethodsA single-center observational study evaluating VCD (MANTA,...
Clinical outcome following acute myocardial infarction is predicted by final infarct size evaluated in relation to left ventricular myocardium at risk (MaR). Contrast-enhanced steady-state free precession (CE-SSFP) cardiovascular magnetic resonance imaging (CMR) not widely used for assessing MaR. Evidence of its utility compared traditional assessment methods and as a surrogate clinical needed.
Abstract To study the relationship between myocardial infarction size (IS), edema, and diastolic dysfunction after acute (MI) both in phase, development of follow-up setting. A further purpose is to function using a mechanistic model as well conventional parameters. Patients underwent cardiovascular magnetic resonance (CMR) imaging echocardiography including analysis parameterized filling method within 4–7 days (acute) 6 months first anterior MI (n = 74). Linear regression modeling...
Remote ischemic conditioning (RIC), brief repetitive cycles of ischemia and reperfusion in remote tissues, is known to induce robust protection against myocardial ischemia-reperfusion (I/R) injury preclinical studies. However, translation the beneficial effects clinical setting has been challenging. A possibility that comorbidities, including hypercholesterolemia, interfere with protective mechanisms RIC. The aim this study was test if hypercholesterolemia attenuates efficacy RIC patients...
Background: Ticagrelor is a recommended P2Y 12 receptor inhibitor after acute coronary syndrome (ACS). Its superiority has been suggested to rely on pleiotropic effects beyond platelet inhibition. Experimental studies indicate that ticagrelor may protect from ischemia-reperfusion injury but no data are available such patients. This study aimed determine if chronic treatment protects against endothelial in patients with previous ACS. Methods: Patients ACS were studied flow mediated dilatation...
Small femoral arteries have been associated with a higher risk of vascular complications in transfemoral transcatheter aortic valve replacement (TAVR). We investigated the feasibility and safety TAVR patients small arteries. In this observational study, we included 82 who underwent ACURATE neo system using expandable 14F iSleeve sheath between 2018 2019 at Karolinska University Hospital, Sweden. Of these, 41 had minimal artery diameter ≥5.5 mm (mean 6.5, range 5.5-9.2), <5.5 4.9, 3.9-5.4)....
A pulmonary vein isolation procedure in a patient with an atrial septal defect (ASD) closure device was complicated by entrapment of mapping catheter the device. The converted to open heart surgery, trapped explanted, ASD covered bovine patch, and cryomaze performed. (Level Difficulty: Intermediate.)