David J. Werring
A5088937468- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and genetic disorders
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Venous Thromboembolism Diagnosis and Management
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Long-Term Effects of COVID-19
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological and metabolic disorders
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurological Complications and Syndromes
- Advanced MRI Techniques and Applications
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2016-2025
University College London Hospitals NHS Foundation Trust
2008-2025
University College Hospital
2012-2024
Biomedical Research Institute
2016-2024
Hospital de Sant Pau
2022-2024
NIHR Queen Square Dementia Biomedical Research Unit
2007-2024
University of Nottingham
2016-2024
MRC Prion Unit
2024
Medical University of Graz
2023-2024
Abstract Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 order discuss begin understand presentations patients suspected COVID-19-related disorders. Detailed paraclinical were collected from cases...
Brain microbleeds on gradient-recalled echo (GRE) T2*-weighted MRI may be a useful biomarker for bleeding-prone small vessel diseases, with potential relevance diagnosis, prognosis (especially antithrombotic-related bleeding risk), and understanding mechanisms of symptoms, including cognitive impairment. To address these questions, it is necessary to reliably measure their presence distribution in the brain. We designed systematically validated Microbleed Anatomical Rating Scale (MARS)....
To determine whether diffusion tensor imaging (DTI) can detect structural changes in normal-appearing white matter, and to distinguish between plaques of different pathologic severity, patients with MS.Conventional MRI detects lesions sensitively MS but has limited specificity. The water molecules brain tissue, most fully expressed mathematically by a quantity, reflects its intrinsic microstructure. It is now possible estimate the noninvasively human using MR DTI. This method unique...
Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...
Gradient echo T2*-weighted MRI has high sensitivity in detecting cerebral microbleeds, which appear as small dot-like hypointense lesions. Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic vessel disease, have generated interest a marker of bleeding-prone microangiopathy. generally been considered to be clinically silent; however, since they located widespread cortical basal ganglia regions histologically characterized by tissue...
BackgroundTranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed assess whether tranexamic reduces haematoma expansion improves outcome in adults with stroke intracerebral haemorrhage.MethodsWe did an international, randomised placebo-controlled trial haemorrhage from acute units at 124 hospital sites 12 countries. Participants were randomly assigned (1:1) receive 1 g intravenous bolus followed by 8 h infusion of or a matching placebo, within...
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that prone to intracranial bleeding. We aimed determine whether presence can identify patients at high risk symptomatic haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient attack.
Perivascular spaces that are visible on magnetic resonance imaging (MRI) a neuroimaging marker of cerebral small vessel disease. Their location may relate to the type underlying pathology: those in white matter centrum semi-ovale have been associated with amyloid angiopathy, while basal ganglia deep perforating artery arteriolosclerosis. As angiopathy is an almost invariable pathological finding Alzheimer's disease, we hypothesized MRI-visible perivascular would be clinical diagnosis whereas...