A5037024422- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
- Retinal and Optic Conditions
- Genetic Neurodegenerative Diseases
- Myasthenia Gravis and Thymoma
- Hormonal Regulation and Hypertension
- Esophageal and GI Pathology
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Infectious Encephalopathies and Encephalitis
- Immune Response and Inflammation
- Intestinal and Peritoneal Adhesions
- Vasculitis and related conditions
- Venous Thromboembolism Diagnosis and Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protease and Inhibitor Mechanisms
- Cellular transport and secretion
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
Hospital Universitario 12 De Octubre
2016-2025
Research Institute Hospital 12 de Octubre
2019-2025
Hospital de Egas Moniz
2022
University of Thessaly
2022
Boston University
2022
Boston Medical Center
2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2021
Hospital Clínic de Barcelona
2021
Universitat de Barcelona
2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Background and Purpose— Recanalization of the occluded artery is a primary goal in stroke treatment. Unfortunately, endovascular treatment not always available, tPA (tissue-type plasminogen activator) therapy limited by its narrow therapeutic window; importantly, rate early arterial recanalization after administration low, especially for platelet-rich thrombi. The mechanisms this resistance are well known. Since neutrophil extracellular traps (NETs) have been implicated setting, our aim was...
Background and Purpose: The coronavirus disease 2019 (COVID-19) outbreak has added challenges to providing quality acute stroke care due the reallocation of resources COVID-19. Case series suggest that patients with COVID-19 have more severe strokes; however, no large compared outcomes contemporary non–COVID-19 patients. Purpose was analyze impact pandemic in evaluate according diagnosis Methods: Retrospective multicenter cohort study including consecutive admitted 7 centers from February 25...
<h3>PURPOSE:</h3> Our aim was to study the association between abnormal findings on chest and brain imaging in patients with coronavirus disease 2019 (COVID-19) neurologic symptoms. <h3>MATERIALS AND METHODS:</h3> In this retrospective, international multicenter study, we reviewed electronic medical records of hospitalized COVID-19 from March 3, 2020, June 25, 2020. inclusion criteria were diagnosed Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) infection acute manifestations available CT...
ABSTRACT BACKGROUND. Ischemic stroke, a major cause of death and disability, triggers immune suppression inflammation, increasing the risk infections, particularly early post-stroke. These infections worsen outcomes, prolong hospitalization, lack reliable predictive protocols. Current management with broad-spectrum antibiotics is not proven effective may disrupt microbiota balance. Neutrophil elastase (NE), vital for defense, can exacerbate inflammation infection susceptibility. The main...
Introduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed outcomes and safety EVT c-ICA-O. Methods: Retrospective multicenter cohort study an AIS c-ICA-O, within 24-h since last-seen-well. Comparisons were made between best medical (BMT). The primary outcome was 3-months modified Rankin Scale (mRS) ordinal shift. Secondary included 3-month...
Background: Ischemic stroke is the most common and severe arterial thrombotic event in Antiphospholipid syndrome (APS). APS an autoimmune disease characterized by presence of thrombosis antiphospholipid antibodies (aPL), which provide a pro-coagulant state. The aPL included classification criteria are lupus anticoagulant, anti-cardiolipin (aCL) anti-β2-glycoprotein-I (aB2GPI) IgG IgM isotypes. Extra-criteria aPL, especially IgA aB2GPI IgG/IgM anti-phosphatidylserine/prothrombin (aPS/PT),...
The experience gained during the first COVID-19 wave could have mitigated negative impact on stroke care in following waves. Our aims were to analyze characteristics and outcomes of patients with admitted second evaluate differences provision compared wave.This retrospective multicenter cohort study included consecutive any seven hospitals units (SUs) endovascular treatment facilities Madrid Health Region. or without a diagnosis organizational changes between (25 February 25 April 2020) (21...
A 58-year-old man presented with 1 month subacute onset of instability, oscillopsia, vertigo, nausea, and vomiting. Neurologic examination revealed gaze-evoked prominently downbeat nystagmus, left eyelid ptosis, gait cerebellar ataxia (Videos Videos 2). There was no dysarthria or dysmetria. Head MRI unremarkable lumbar puncture showed mild lymphocyte predominant pleocytosis normal proteins. EMG abnormalities. Cancer not identified. Serum CSF septin-5–specific immunoglobulin G identified by...
Tenecteplase (TNK) is a fibrinolytic drug that administrated in single bolus, recommended eligible patients with acute ischemic stroke prior to mechanical thrombectomy. This study explores its usefulness adverse situations, such as the SARS-CoV-2 pandemic. We conducted retrospective involving consecutive suspected treated either intravenous fibrinolysis alteplase during 2019 or TNK (.25 mg/kg) between March 2020 and February 2021. A comparative analysis was made compare patient treatment...
Congenital myasthenic syndromes are clinically and genetically heterogeneous disorders characterized by a neuromuscular transmission defect. Mutations in novel genes have been described recent years. Among these, MUSK gene mutations extremely rare, with only 8 families identified worldwide to date. We report Spanish case, carrier of one known hetero-allelic missense mutation newly variant. Our patient presented congenital onset ophthalmoplegia palpebral ptosis associated limb-girdle weakness...
Convergence insufficiency (CI) is a frequent clinical condition primarily of idiopathic etiology. Neurological causes are secondary, and in the case cerebral infarctions, symptoms do not always correlate with location. We present middle-aged man who experienced left anterior choroidal artery stroke marked symptomatic CI. In addition to having multiple cardiovascular risk factors, he also had antiphospholipid syndrome as possible contributing cause.
In atherosclerotic patients undergoing coronary artery‐bypass grafting (CABG) it has been shown decreased numbers of endothelial progenitor CD144+ cells, compared to artery disease‐free valvular (1). At the same time, Ets‐2 is a transcription factor involved in differentiation and basic clinical models vascular remodelling. We aimed determine expression CD144 peripheral blood mononuclear cells from CABG patients, role inhibition on expression. was determined obtained 15 16 patients. silenced...
Vasculitis primaria del sistema nervioso con afectación arterial y venosa.